Background:
It is possible that patients with pneumonia also may have sepsis and the separation of these two
clinical entities may induce some trouble to clinicians
Objective:
In order to separate a patient with pneumonia and a patient with sepsis, we qualify thiol/disulfide homeostasis as
a potential biomarker.
Method:
This study designed between February 2018 – February 2019 prospectively. All patients in the intensive care unit
with pneumonia and sepsis were enrolled in the study. At the time of hospitalization, thiol/disulfide homeostasis was measured.
Patients diagnosed with sepsis and pneumonia were compared, in regards to thiol/disulfide homeostasis.
Conclusion:
In this study, we showed that thiol/disulfide homeostasis can be used as new markers in the early period in order
to separate patients with sepsis and patients with pneumonia.
Results:
During research period, 103 patients with sepsis and 120 patients with pneumonia were enrolled into the study.
When we compared native-thiol, total-thiol, and disulfide levels in both sepsis and pneumonia patients, we had similar results
(p>0.05). In sepsis group, index-1 (disulfide/native thiol ratio) and index-2 (disulfide/total thiol ratio) were found out to
be statistically higher than the pneumonia group, and index-3 (native thiol/total thiol ratio) was statistically lower than the
pneumonia group (p=0.020, p= 0.021, p=0.021, respectively).