Shear Stress and Nitric Oxide Release: Physiological Integration of Cellular Mechanisms, Physical Forces and Flow Regulation

Author(s):  
Tudor M Griffith
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Vol 15 (5) ◽  
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Blood pressure instability may promote cardiovascular morbidity. Recent data suggest a role of nitric oxide in stabilizing arterial blood pressure. A rise in blood pressure enhances endothelial shear stress and nitric oxide release. The resulting vasodilation antagonizes the initial increase in blood pressure. This system can respond within 2–10 seconds.


Nitric Oxide ◽  
2001 ◽  
Vol 5 (5) ◽  
pp. 453-464 ◽  
Author(s):  
Jodi M. Schoen ◽  
H.Helen Wang ◽  
Gerald Y. Minuk ◽  
W.Wayne Lautt

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