A NEW INTERNATIONAL STANDARD FOR “ACTIONS FROM WAVES AND CURRENTS ON COASTAL STRUCTURES”

2007 ◽  
Author(s):  
Alf Tørum ◽  
Hans Burcharth ◽  
Yoshimi Goda ◽  
Andreas Kortenhaus ◽  
David Kriebel
Keyword(s):  
Coastal Structures ◽  
International Standard ◽  
Waves And Currents

COASTAL ENGINEERING 2000

2000 ◽  
Vol 1 (27) ◽  
Author(s):  
Billy L. Edge
Keyword(s):  
Wind Waves ◽  
Storm Surges ◽  
Coastal Engineering ◽  
Coastal Processes ◽  
Coastal Structures ◽  
Wave Groups ◽  
Coastal Waves ◽  
Waves And Currents ◽  
The Individual ◽  
Engineering Projects

*** Available Only Through ASCE *** http://ascelibrary.aip.org/browse/asce/vol_title.jsp?scode=C This Proceedings contains more than 300 papers presented at the 27th International Conference on Coastal Engineering, which was held in Sydney, Australia, 16-21 July 2000. The Proceedings is divided into five parts: characteristics of coastal waves and currents; long period waves, storm surges and wave groups; coastal structures; coastal processes and sediment transport; and coastal, estuarine, and environmental problems. The individual papers include such topics as the effects of wind, waves, storms, and currents as well as the study of sedimentation, erosion, and beach nourishment. Special emphasis is given to case studies of completed engineering projects. With the inclusion of both theoretical and practical information, these papers provide the civil engineer and professionals in related fields with a broad range of information on coastal engineering and coastal processes affecting design and operations in the coastal zone.This Proceedings contains more than 300 papers presented at the 27th International Conference on Coastal Engineering, which was held in Sydney, Australia, 16-21 July 2000. The Proceedings is divided into five parts: characteristics of coastal waves and currents; long period waves, storm surges and wave groups; coastal structures; coastal processes and sediment transport; and coastal, estuarine, and environmental problems. The individual papers include such topics as the effects of wind, waves, storms, and currents as well as the study of sedimentation, erosion, and beach nourishment. Special emphasis is given to case studies of completed engineering projects. With the inclusion of both theoretical and practical information, these papers provide the civil engineer and professionals in related fields with a broad range of information on coastal engineering and coastal processes affecting design and operations in the coastal zone.This Proceedings contains more than 300 papers presented at the 27th International Conference on Coastal Engineering, which was held in Sydney, Australia, 16-21 July 2000. The Proceedings is divided into five parts: characteristics of coastal waves and currents; long period waves, storm surges and wave groups; coastal structures; coastal processes and sediment transport; and coastal, estuarine, and environmental problems. The individual papers include such topics as the effects of wind, waves, storms, and currents as well as the study of sedimentation, erosion, and beach nourishment. Special emphasis is given to case studies of completed engineering projects. With the inclusion of both theoretical and practical information, these papers provide the civil engineer and professionals in related fields with a broad range of information on coastal engineering and coastal processes affecting design and operations in the coastal zone. *********** This volume was originally published by ASCE. ASCE database link, for record and hard copy purchase: http://cedb.asce.org/cgi/WWWdisplay.cgi?126156

scholarly journals Field Application of the Slit Type Coastal Structures under Waves and Currents

2010 ◽  
Vol 34 (9) ◽  
pp. 711-718
Author(s):  
Sang-Gil Park ◽  
Sug-Jin Kang ◽  
Kang-Min Kim ◽  
Suk-Mun Kim ◽  
Joong-Woo Lee
Keyword(s):  
Field Application ◽  
Coastal Structures ◽  
Waves And Currents

Naloxon – Medizinische Grundlagen und internationale Erfahrungen

2019 ◽  
Vol 65 (5) ◽  
pp. 335-342
Author(s):  
Norbert Wodarz ◽  
Jörg Wolstein ◽  
Heike Wodarz-von Essen ◽  
Oliver Pogarell
Keyword(s):  
Randomized Controlled Trial ◽  
Glasgow Coma Scale ◽  
Controlled Trial ◽  
Cochrane Library ◽  
Coma Scale ◽  
International Standard ◽  
Trial Number ◽  
Randomized Controlled ◽  
Opioid Crisis ◽  
Lebensrettende Basismaßnahmen

Zusammenfassung. Hintergrund: Die Abhängigkeit von Opioiden ist mit erheblichen gesundheitlichen Gefährdungen der Betroffenen und einer hohen Mortalität assoziiert. Derzeit werden insbesondere die dramatisch gestiegenen Mortalitätsraten in den USA diskutiert (‚opioid crisis‘), aber auch in Deutschland war in den letzten Jahren ein kontinuierlicher Anstieg der Drogentoten, überwiegend verursacht durch Opioide, zu verzeichnen. Die Risiken einer Opioid Überdosierung bzw. Intoxikation resultiert vor allem aus der hemmenden Wirkung der Opioide auf den Atemantrieb, die durch andere gleichzeitig konsumierte Substanzen noch verstärkt werden kann. Neben Erstmaßnahmen (Notruf, lebensrettende Basismaßnahmen der Ersten Hilfe) kommt auch der Einsatz des Opioidantagonisten Naloxon in Betracht. Methode: Literaturrecherche in PubMed, Cochrane Library und im International Standard Randomized Controlled Trial Number (ISRCTN) Register. Ergebnisse: Auch aus ethischen Gründen liegen bislang eher wenig systematische Untersuchungen zum nicht-ärztlichen Einsatz von Naloxon bei Opioidüberdosierung vor. Trotzdem kann nach aktuellem Stand geschlussfolgert werden, dass die intranasale Verabreichung vergleichbar wirksam mit einer intramuskulären Anwendung zu sein scheint. Bei Überdosierten, die nach erfolgreichem Naloxon-Einsatz aus unterschiedlichen Gründen nicht in einer Klinik gebracht wurden, wurden in ca. 1 %. Todesfälle dokumentiert. Falls 60 min nach Naloxongabe unauffällige Vitalparameter und auf der Glasgow Coma Scale mind. 15 Punkte erreicht werden, besteht wohl ein sehr niedriges Rebound-Risiko. Im Vergleich dazu ist das Auftreten von Naloxon-induzierten Entzugssyndromen deutlich häufiger, hängen jedoch von der Dosis und dem konsumierten Opioid ab, wie auch von der verabreichten Naloxon-Dosis. Schlussfolgerungen: Naloxon kann mittlerweile auch in Deutschland als zugelassenes Nasalspray verabreicht werden und ist daher im Prinzip auch für den Einsatz durch Ersthelfer geeignet. Verbesserte Rahmenbedingungen, wie z. B. spezifische Schulungen könnten dazu beitragen, Take-Home Naloxon als erfolgreichen Baustein zur Reduktion von Drogentod zu implementieren.

A Collaborative Study to Establish the 2nd International Standard for Tissue Plasminogen Activator (t-PA)

1987 ◽  
Vol 58 (04) ◽  
pp. 1085-1087 ◽  
Author(s):  
P J Gaffney ◽  
A D Curtis
Keyword(s):  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Collaborative Study ◽  
Chinese Hamster ◽  
World Health ◽  
Clot Lysis ◽  
Expert Committee ◽  
Single Chain ◽  
International Standard ◽  
Tissue Plasminogen

SummaryAn international collaborative study involving ten laboratories located in eight different countries was undertaken in order to replace the current International Standard (I.S.) for tissue plasminogen activator (t-PA). Two lyophilised candidate preparations of high purity were assessed in comparison with the current I.S. for t-PA using only a clot lysis assay. One preparation (coded 861670) was purified from a cultured melanoma cell supernatant and was about 98% single chain t-PA while the other preparation (coded 861624) was derived from Chinese hamster ovary (CHO) cells following DNA recombinant procedures and was 75% single chain t-PA.Both candidate preparations of t-PA compared in quite a satisfactory manner with the current I.S. from the viewpoint of the biometrics of parallel line bioassays and both preparations were quite stable for long periods at low temperatures and stable from up to 1 month at temperatures of 20° and 38° C. Both fultil the criteria to serve as a satisfactory Znd International Standard for t-PA. The Fibrinolysis Subcommittee of the International Committee for Thrombosis and Haemostasis recommended the melanoma source t-PA (861670) as the next I.S. in order to maintain continuity with the 1st I.S. which was also a melanomatype preparation. The data from the ten laboratories indicated that each ampoule of the new proposed standard contains 850 international units of t-PA activity by the clot lysis assay. It is planned to present the results of this study to the Expert Committee on Biological Standardization of the World Health Organization at its next meeting and to request that the preparation of t-PA, coded 861670, be established as the 2ndlnternational Standard for t-PA.

A Collaborative Study to Establish the Second International Standard for Streptokinase

1990 ◽  
Vol 64 (02) ◽  
pp. 267-269 ◽  
Author(s):  
A B Heath ◽  
P J Gaffney
Keyword(s):  
High Purity ◽  
Collaborative Study ◽  
World Health Organisation ◽  
World Health ◽  
Clot Lysis ◽  
Current Standard ◽  
International Standard ◽  
Accelerated Degradation ◽  
The World ◽  
International Collaborative Study

SummaryAn International Standard for Streptokinase - Streptodomase (62/7) has been used to calibrate high purity clinical batches of SK since 1965. An international collaborative study, involving six laboratories, was undertaken to replace this standard with a high purity standard for SK. Two candidate preparations (88/826 and 88/824) were compared by a clot lysis assay with the current standard (62/7). Potencies of 671 i.u. and 461 i.u. were established for preparations A (88/826) and B (88/824), respectively.Either preparation appeared suitable to serve as a standard for SK. However, each ampoule of preparation A (88/826) contains a more appropriate amount of SK activity for potency testing, and is therefore preferred. Accelerated degradation tests indicate that preparation A (88/826) is very stable.The high purity streptokinase preparation, coded 88/826, has been established by the World Health Organisation as the 2nd International Standard for Streptokinase, with an assigned potency of 700 i.u. per ampoule.

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