Visualization of Protein Sequences Using the Two-Dimensional Hydrophobic Cluster Analysis Method

1995 ◽  
pp. 129-144
Author(s):  
Michel T. Semertzidis ◽  
Etienne Thoreau ◽  
Anne Tasso ◽  
Bernard Henrissat ◽  
Isabelle Callebaut ◽  
...  
Biochimie ◽  
1990 ◽  
Vol 72 (8) ◽  
pp. 555-574 ◽  
Author(s):  
L. Lemesle-Varloot ◽  
B. Henrissat ◽  
C. Gaboriaud ◽  
V. Bissery ◽  
A. Morgat ◽  
...  

1988 ◽  
Vol 255 (3) ◽  
pp. 901-905 ◽  
Author(s):  
B Henrissat ◽  
Y Popineau ◽  
J C Kader

Hydrophobic-cluster analysis was used to characterize a conserved domain located near the C-terminal amino acid sequence of wheat (Triticum aestivum) storage proteins. This domain was transformed into a linear template for a global search for similarities in over 5200 protein sequences. In addition to proteins that had already been found to exhibit homology to wheat storage proteins, a previously unreported homology was found with non-specific lipid-transfer proteins from castor bean (Ricinus communis) and from spinach (Spinacia oleracea) leaf. Hydrophobic-cluster analysis of various members of the present protein group clearly shows a typical domain structure where (i) variable and conserved domains are located along the sequence at precise positions, (ii) the conserved domains probably reflect a common ancestor, and (iii) the unique properties of a given protein (chain cut into subunits, repetitive domains, trypsin-inhibitor active site) are associated with the variable domains.


2011 ◽  
Vol 22 (8) ◽  
pp. 1827-1837 ◽  
Author(s):  
Dong-Ming TANG ◽  
Qing-Xin ZHU ◽  
Fan YANG ◽  
Ke CHEN

PROTEOMICS ◽  
2018 ◽  
Vol 18 (21-22) ◽  
pp. 1800054 ◽  
Author(s):  
Tristan Bitard-Feildel ◽  
Alexis Lamiable ◽  
Jean-Paul Mornon ◽  
Isabelle Callebaut

2018 ◽  
Author(s):  
Tristan Bitard-Feildel ◽  
Isabelle Callebaut

AbstractMotivation: Detecting protein domains sharing no similarity to known domains, as stored in domain databases, is a challenging problem, particularly for unannotated proteomes, domains emerged recently, fast diverging proteins or domains with intrinsically disordered regions.Results: We developed pyHCA and HCAtk, a python API and standalone tool gathering together improved versions of previously developed methodologies, with new functionalities. The developed tools can be either used from command line or from a python API.Availability: HCAtk and pyHCA are available at https://github.com/T-B-F/pyHCA under the CeCILL-C license.


1993 ◽  
Vol 9 (1) ◽  
pp. 37-44 ◽  
Author(s):  
L. Lemesle-Varloot ◽  
C. Gaboriaud ◽  
A. Morgat ◽  
G. Pantel ◽  
J. P. Mornon ◽  
...  

2010 ◽  
Vol 41 (2) ◽  
pp. 126-133 ◽  
Author(s):  
N. Kalamaras ◽  
H. Michalopoulou ◽  
H. R. Byun

In this study a method proposed by Byun & Wilhite, which estimates drought severity and duration using daily precipitation values, is applied to data from stations at different locations in Greece. Subsequently, a series of indices is calculated to facilitate the detection of drought events at these sites. The results provide insight into the trend of drought severity in the region. In addition, the seasonal distribution of days with moderate and severe drought is examined. Finally, the Hierarchical Cluster Analysis method is used to identify sites with similar drought features.


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