The Importance of Physiologically Inspired Physicochemical Parameters on Hematopoietic Stem-Cell Maintenance and Lineage-Specific Differentiation in Ex Vivo Cultures

Stem Cells ◽  
2011 ◽  
pp. 159-195
Author(s):  
Stephan Lindsey ◽  
Eleftherios T. Papoutsakis
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Physicochemical Parameters ◽  
Ex Vivo ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Specific Differentiation ◽  
Cell Maintenance

scholarly journals MicroRNA-127-3p controls murine hematopoietic stem cell maintenance by limiting differentiation

Haematologica ◽  
2019 ◽  
Vol 104 (9) ◽  
pp. 1744-1755 ◽  
Author(s):  
Laura Crisafulli ◽  
Sharon Muggeo ◽  
Paolo Uva ◽  
Yulei Wang ◽  
Masayuki Iwasaki ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Murine Hematopoietic Stem Cell ◽  
Cell Maintenance

scholarly journals Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization

2011 ◽  
Vol 208 (13) ◽  
pp. 2761-2761
Author(s):  
Kana Miyamoto ◽  
Shigeyuki Yoshida ◽  
Miyuri Kawasumi ◽  
Kazuaki Hashimoto ◽  
Tokuhiro Kimura ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Cell Maintenance

scholarly journals The control of hematopoietic stem cell maintenance, self-renewal, and differentiation by Mysm1-mediated epigenetic regulation

Blood ◽  
2013 ◽  
Vol 122 (16) ◽  
pp. 2812-2822 ◽  
Author(s):  
Tao Wang ◽  
Vijayalakshmi Nandakumar ◽  
Xiao-Xia Jiang ◽  
Lindsey Jones ◽  
An-Gang Yang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Histone Modifications ◽  
Epigenetic Regulation ◽  
Self Renewal ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Key Points ◽  
And Function ◽  
Cell Maintenance

Key Points Mysm1 is required to maintain the quiescence and pool size of HSC, and its deletion severely impairs the survival and function of HSC. Mysm1 controls HSC homeostasis by regulating Gfi1 expression via modulating histone modifications and transcriptional factors recruitment.

scholarly journals Osteoclasts are not crucial for hematopoietic stem cell maintenance in adult mice

Haematologica ◽  
2013 ◽  
Vol 98 (12) ◽  
pp. 1848-1855 ◽  
Author(s):  
C. Flores ◽  
I. Moscatelli ◽  
C. S. Thudium ◽  
N. S. Gudmann ◽  
J. S. Thomsen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Adult Mice ◽  
Cell Maintenance

scholarly journals The MicroRNA-132 and MicroRNA-212 Cluster Regulates Hematopoietic Stem Cell Maintenance and Survival with Age by Buffering FOXO3 Expression

Immunity ◽  
2015 ◽  
Vol 42 (6) ◽  
pp. 1021-1032 ◽  
Author(s):  
Arnav Mehta ◽  
Jimmy L. Zhao ◽  
Nikita Sinha ◽  
Georgi K. Marinov ◽  
Mati Mann ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Cell Maintenance

scholarly journals HDAC8 regulates long-term hematopoietic stem-cell maintenance under stress by modulating p53 activity

Blood ◽  
2017 ◽  
Vol 130 (24) ◽  
pp. 2619-2630 ◽  
Author(s):  
Wei-Kai Hua ◽  
Jing Qi ◽  
Qi Cai ◽  
Emily Carnahan ◽  
Maria Ayala Ramirez ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Key Points ◽  
Cell Maintenance

Key Points HDAC8 plays a key role in maintaining long-term hematopoietic repopulation. HDAC8 modulates p53 activity to ensure LT-HSC cell survival under stress.

scholarly journals A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

2012 ◽  
Vol 18 (9) ◽  
pp. 1350-1358 ◽  
Author(s):  
Keisuke Ito ◽  
Arkaitz Carracedo ◽  
Dror Weiss ◽  
Fumio Arai ◽  
Ugo Ala ◽  
...  
Keyword(s):  
Stem Cell ◽  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Hematopoietic Stem Cell ◽  
Acid Oxidation ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Cell Maintenance

scholarly journals Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance

Haematologica ◽  
2019 ◽  
Vol 105 (3) ◽  
pp. 573-584 ◽  
Author(s):  
Cuiping Zhang ◽  
Yvonne N Fondufe-Mittendorf ◽  
Chi Wang ◽  
Jin Chen ◽  
Qiang Cheng ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Cell Maintenance
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