scholarly journals The control of hematopoietic stem cell maintenance, self-renewal, and differentiation by Mysm1-mediated epigenetic regulation

Blood ◽  
2013 ◽  
Vol 122 (16) ◽  
pp. 2812-2822 ◽  
Author(s):  
Tao Wang ◽  
Vijayalakshmi Nandakumar ◽  
Xiao-Xia Jiang ◽  
Lindsey Jones ◽  
An-Gang Yang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Histone Modifications ◽  
Epigenetic Regulation ◽  
Self Renewal ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Key Points ◽  
And Function ◽  
Cell Maintenance

Key Points Mysm1 is required to maintain the quiescence and pool size of HSC, and its deletion severely impairs the survival and function of HSC. Mysm1 controls HSC homeostasis by regulating Gfi1 expression via modulating histone modifications and transcriptional factors recruitment.

Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance

Blood ◽  
2013 ◽  
Vol 122 (10) ◽  
pp. 1741-1745 ◽  
Author(s):  
Amelie V. Guitart ◽  
Chithra Subramani ◽  
Alejandro Armesilla-Diaz ◽  
Gillian Smith ◽  
Catarina Sepulveda ◽  
...  
Keyword(s):  
Stem Cell ◽  
Steady State ◽  
Hematopoietic Stem Cell ◽  
Self Renewal ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Key Points ◽  
Cell Maintenance

Key Points Hif-2α–dependent signaling is dispensable for steady-state multilineage hematopoiesis. Hif-2α is not essential for HSC self-renewal.

scholarly journals HDAC8 regulates long-term hematopoietic stem-cell maintenance under stress by modulating p53 activity

Blood ◽  
2017 ◽  
Vol 130 (24) ◽  
pp. 2619-2630 ◽  
Author(s):  
Wei-Kai Hua ◽  
Jing Qi ◽  
Qi Cai ◽  
Emily Carnahan ◽  
Maria Ayala Ramirez ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Key Points ◽  
Cell Maintenance

Key Points HDAC8 plays a key role in maintaining long-term hematopoietic repopulation. HDAC8 modulates p53 activity to ensure LT-HSC cell survival under stress.

scholarly journals Gab2 Promotes Hematopoietic Stem Cell Maintenance and Self-Renewal Synergistically with STAT5

PLoS ONE ◽  
2010 ◽  
Vol 5 (2) ◽  
pp. e9152 ◽  
Author(s):  
Geqiang Li ◽  
Zhengqi Wang ◽  
Kristy L. Miskimen ◽  
Yi Zhang ◽  
William Tse ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Self Renewal ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Cell Maintenance

scholarly journals LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance

Blood ◽  
2013 ◽  
Vol 121 (6) ◽  
pp. 918-929 ◽  
Author(s):  
Sung-Uk Lee ◽  
Manami Maeda ◽  
Yuichi Ishikawa ◽  
Sierra Min Li ◽  
Anne Wilson ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Cell Differentiation ◽  
T Cell ◽  
T Cell Differentiation ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Key Points ◽  
And Function ◽  
Cell Maintenance

Key Points Notch1/DII4-mediated signals are normally suppressed by LRF, preventing HSCs from premature T-cell differentiation in the bone marrow. Erythroblastic islands may have the capacity to regulate the fate and function of HSCs.

scholarly journals MicroRNA-127-3p controls murine hematopoietic stem cell maintenance by limiting differentiation

Haematologica ◽  
2019 ◽  
Vol 104 (9) ◽  
pp. 1744-1755 ◽  
Author(s):  
Laura Crisafulli ◽  
Sharon Muggeo ◽  
Paolo Uva ◽  
Yulei Wang ◽  
Masayuki Iwasaki ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Murine Hematopoietic Stem Cell ◽  
Cell Maintenance

scholarly journals Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization

2011 ◽  
Vol 208 (13) ◽  
pp. 2761-2761
Author(s):  
Kana Miyamoto ◽  
Shigeyuki Yoshida ◽  
Miyuri Kawasumi ◽  
Kazuaki Hashimoto ◽  
Tokuhiro Kimura ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Cell Maintenance
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