A NOVEL ELECTRICAL STIMULATION PARADIGM FOR THE SUPPRESSION OF EPILEPTIFORM ACTIVITY IN ANIN VIVOMODEL OF MESIAL TEMPORAL LOBE STATUS EPILEPTICUS

2012 ◽  
Vol 22 (03) ◽  
pp. 1250006 ◽  
Author(s):  
YUANG TANG ◽  
DOMINIQUE M. DURAND
Keyword(s):  
Electrical Stimulation ◽  
Temporal Lobe ◽  
Epileptiform Activity ◽  
Low Frequency ◽  
Mesial Temporal Lobe Epilepsy ◽  
Control Group ◽  
Hippocampal Commissure ◽  
Hippocampal Network ◽  
Mesial Temporal Lobe ◽  
Stimulation Paradigm

In this study, we present a novel low-frequency electrical stimulation paradigm for mesial temporal lobe epilepsy (MTLE). The paradigm utilizes the hippocampal commissure as a unique stimulation target to simultaneously influence large portions of the bilateral hippocampal network. When applied to an acute rat model of MTLE, animals that received stimulation exhibited an 88% reduction in the signal power of the bilateral epileptiform activity relative to the control group. In addition, the stimulation entrained the hippocampal network's spontaneous epileptiform activity and disrupted its bilateral synchrony.

Low Frequency Electrical Stimulation of White Matter Tracts in Intractable Mesial Temporal Lobe Epilepsy (S46.007)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. S46.007-S46.007
Author(s):  
M. Koubeissi ◽  
D. Durand ◽  
E. Kahriman ◽  
T. Syed ◽  
J. Miller ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
White Matter ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Low Frequency ◽  
Mesial Temporal Lobe Epilepsy ◽  
White Matter Tracts ◽  
Mesial Temporal Lobe ◽  
Stimulation Of

Low Frequency Electrical Stimulation of White Matter Tracts in Intractable Mesial Temporal Lobe Epilepsy (IN5-1.010)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. IN5-1.010-IN5-1.010
Author(s):  
M. Koubeissi ◽  
D. Durand ◽  
E. Kahriman ◽  
T. Syed ◽  
J. Miller ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
White Matter ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Low Frequency ◽  
Mesial Temporal Lobe Epilepsy ◽  
White Matter Tracts ◽  
Mesial Temporal Lobe ◽  
Stimulation Of

Electrical Stimulation of Subiculum for the Treatment of Refractory Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis: A 2-Year Follow-Up Study

2020 ◽  
pp. 1-8
Author(s):  
Daruni Vázquez-Barrón ◽  
Manola Cuéllar-Herrera ◽  
Francisco Velasco ◽  
Ana Luisa Velasco
Keyword(s):  
Electrical Stimulation ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Hippocampal Sclerosis ◽  
Mesial Temporal Lobe Epilepsy ◽  
Open Label ◽  
Anticonvulsive Effect ◽  
Mesial Temporal Lobe ◽  
Stimulation Of

<b><i>Introduction:</i></b> Evidence has been provided that the subiculum may play an important role in the generation of seizures. Electrical stimulation at this target has been reported to have anticonvulsive effects in kindling and pilocarpine rat models, while in a clinical study of hippocampal deep brain stimulation (DBS), contacts closest to the subiculum were associated with a better anticonvulsive effect. <b><i>Objectives:</i></b> To evaluate the effect of electrical stimulation of the subiculum in patients with refractory mesial temporal lobe epilepsy (MTLE) who have hippocampal sclerosis (HS). <b><i>Methods:</i></b> Six patients with refractory MTLE and HS, who had focal impaired awareness seizures (FIAS) and focal to bilateral tonic-clonic seizures (FBTCS), had DBS electrodes implanted in the subiculum. During the first month after implantation, all patients were OFF stimulation, then they all completed an open-label follow-up of 24 months ON stimulation. DBS parameters were set at 3 V, 450 µs, 130 Hz, cycling stimulation 1 min ON, 4 min OFF. <b><i>Results:</i></b> There was a mean reduction of 49.16% (±SD 41.65) in total seizure number (FIAS + FBTCS) and a mean reduction of 67.93% (±SD 33.33) in FBTCS at 24 months. FBTCS decreased significantly with respect to baseline, starting from month 2 ON stimulation. <b><i>Conclusions:</i></b> Subiculum stimulation is effective for FBTCS reduction in patients with MTLE and HS, suggesting that the subiculum mediates the generalization rather than the genesis of mesial temporal lobe seizures. Better results are observed at longer follow-up times.

scholarly journals Structural Abnormalities are Similar in Familial and Nonfamilial Mesial Temporal Lobe Epilepsy

2004 ◽  
Vol 31 (3) ◽  
pp. 368-372 ◽  
Author(s):  
Fabio Thadeu Ferreira ◽  
Eliane Kobayashi ◽  
Iscia Lopes-Cendes ◽  
Fernando Cendes
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Visual Analysis ◽  
Mesial Temporal Lobe Epilepsy ◽  
Control Group ◽  
Hippocampal Atrophy ◽  
Anterior Temporal Lobe ◽  
Temporal Lobes ◽  
Mesial Temporal Lobe ◽  
Lobe Atrophy

Background/Objective:Diffuse temporal lobe abnormalities can be observed on MRI of patients with mesial temporal lobe epilepsy (MTLE). Our objective was to perform qualitative and quantitative analyses of temporal lobe structures in patients with familial MTLE (FMTLE) and nonfamilial MTLE.Methods:Two groups of patients were ascertained: 67 FMTLE patients (14 with refractory seizures) and 30 patients with nonfamilial refractory MTLE. We performed qualitative analyses of MRI (with multiplanar reconstruction) and volumes of hippocampi and anterior temporal lobes in all patients, and in a normal control group of 23 individuals. We used the Chi-square test and ANOVA for statistical analyses.Results:We identified anterior temporal lobe abnormalities by visual analysis in only 4% of FMTLE patients and atrophy of the anterior temporal lobe by volumetric analysis in 19%. In the group of nonfamilial MTLE patients we found anterior temporal lobe abnormalities by visual analysis in 17% of patients and anterior temporal lobe atrophy in 13%. Hippocampal atrophy was present in 90% of FMTLE and in 83% of nonfamilial MTLE. No signs of cortical dysplasia were observed.Conclusion:Anterior temporal lobe atrophy and other abnormalities outside the mesial portion of temporal lobes were infrequent in both familial and nonfamilial MTLE patients. Despite the genetic basis, hippocampal atrophy in FMTLE is not associated with other abnormalities outside the mesial temporal regions.

scholarly journals EEG Signal Connectivity for Characterizing Interictal Activity in Patients With Mesial Temporal Lobe Epilepsy

2021 ◽  
Vol 12 ◽  
Author(s):  
Leonardo R. da Costa ◽  
Brunno M. de Campos ◽  
Marina K. M. Alvim ◽  
Gabriela Castellano
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Betweenness Centrality ◽  
Epileptiform Activity ◽  
Mesial Temporal Lobe Epilepsy ◽  
Eeg Signal ◽  
Eeg Signals ◽  
Graph Metrics ◽  
Epileptiform Discharges ◽  
Mesial Temporal Lobe

Over the last decade, several methods for analysis of epileptiform signals in electroencephalography (EEG) have been proposed. These methods mainly use EEG signal features in either the time or the frequency domain to separate regular, interictal, and ictal brain activity. The aim of this work was to evaluate the feasibility of using functional connectivity (FC) based feature extraction methods for the analysis of epileptiform discharges in EEG signals. These signals were obtained from EEG-fMRI sessions of 10 patients with mesial temporal lobe epilepsy (MTLE) with unilateral hippocampal atrophy. The connectivity functions investigated were motif synchronization, imaginary coherence, and magnitude squared coherence in the alpha, beta, and gamma bands of the EEG. EEG signals were sectioned into 1-s epochs and classified according to (using neurologist markers): activity far from interictal epileptiform discharges (IED), activity immediately before an IED and, finally, mid-IED activity. Connectivity matrices for each epoch for each FC function were built, and graph theory was used to obtain the following metrics: strength, cluster coefficient, betweenness centrality, eigenvector centrality (both local and global), and global efficiency. The statistical distributions of these metrics were compared among the three classes, using ANOVA, for each FC function. We found significant differences in all global (p &lt; 0.001) and local (p &lt; 0.00002) graph metrics of the far class compared with before and mid for motif synchronization on the beta band; local betweenness centrality also pointed to a degree of lateralization on the frontotemporal structures. This analysis demonstrates the potential of FC measures, computed using motif synchronization, for the characterization of epileptiform activity of MTLE patients. This methodology may be helpful in the analysis of EEG-fMRI data applied to epileptic foci localization. Nonetheless, the methods must be tested with a larger sample and with other epileptic phenotypes.

Hippocampal electrical stimulation in mesial temporal lobe epilepsy

Neurology ◽  
2006 ◽  
Vol 66 (10) ◽  
pp. 1490-1494 ◽  
Author(s):  
J. F. Tellez-Zenteno ◽  
R. S. McLachlan ◽  
A. Parrent ◽  
C. S. Kubu ◽  
S. Wiebe
Keyword(s):  
Electrical Stimulation ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Mesial Temporal Lobe Epilepsy ◽  
Mesial Temporal Lobe

scholarly journals Brain SPECT in mesial temporal lobe epilepsy: comparison between visual analysis and SPM

2010 ◽  
Vol 68 (2) ◽  
pp. 153-160 ◽  
Author(s):  
Bárbara Juarez Amorim ◽  
Celso Darío Ramos ◽  
Allan Oliveira dos Santos ◽  
Mariana da Cunha Lopes de Lima ◽  
Li Li Min ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Visual Analysis ◽  
Mesial Temporal Lobe Epilepsy ◽  
Brain Spect ◽  
Control Group ◽  
Epileptogenic Focus ◽  
Helpful Tool ◽  
Temporal Lobes ◽  
Mesial Temporal Lobe

OBJECTIVE: To compare the accuracy of SPM and visual analysis of brain SPECT in patients with mesial temporal lobe epilepsy (MTLE). METHOD: Interictal and ictal SPECTs of 22 patients with MTLE were performed. Visual analysis were performed in interictal (VISUAL(inter)) and ictal (VISUAL(ictal/inter)) studies. SPM analysis consisted of comparing interictal (SPM(inter)) and ictal SPECTs (SPM(ictal)) of each patient to control group and by comparing perfusion of temporal lobes in ictal and interictal studies among themselves (SPM(ictal/inter)). RESULTS: For detection of the epileptogenic focus, the sensitivities were as follows: VISUAL(inter)=68%; VISUAL(ictal/inter)=100%; SPM(inter)=45%; SPM(ictal)=64% and SPM(ictal/inter)=77%. SPM was able to detect more areas of hyperperfusion and hypoperfusion. CONCLUSION: SPM did not improve the sensitivity to detect epileptogenic focus. However, SPM detected different regions of hypoperfusion and hyperperfusion and is therefore a helpful tool for better understand pathophysiology of seizures in MTLE.

scholarly journals Electrode location and clinical outcome in hippocampal electrical stimulation for mesial temporal lobe epilepsy

Seizure ◽  
2013 ◽  
Vol 22 (5) ◽  
pp. 390-395 ◽  
Author(s):  
Percy Bondallaz ◽  
Colette Boëx ◽  
Andrea O. Rossetti ◽  
Giovanni Foletti ◽  
Laurent Spinelli ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Clinical Outcome ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Mesial Temporal Lobe Epilepsy ◽  
Electrode Location ◽  
Mesial Temporal Lobe
Sign in / Sign up

Export Citation Format

Share Document