Benefits of Herbal Medicine on Bone Mineral Density in Osteoporosis: A Meta-Analysis of Randomized Controlled Trials

2020 ◽  
Vol 48 (08) ◽  
pp. 1749-1768
Author(s):  
Wan-Ling Lin ◽  
Pao-Yen Lin ◽  
Yu-Chiang Hung ◽  
Tun-Pin Hsueh
Keyword(s):  
Bone Mineral Density ◽  
Herbal Medicine ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Meta Analysis ◽  
Herbal Medicines ◽  
Control Group ◽  
Mineral Density ◽  
China National Knowledge Infrastructure ◽  
Meta Regression Analysis

Bone mineral density (BMD) has been validated not only for the diagnosis of osteoporosis but also for prediction of the risk of osteoporosis-related fractures. The purpose of this paper was to investigate the overall benefits of herbal medicines on BMD using a meta-analytic method. Systematic searches in PubMed, Medline, Cochrane Central, and China National Knowledge Infrastructure were performed for eligible studies. A meta-analysis was conducted to evaluate the benefits of herbal medicine treatment and conventional treatment for BMD. Herbal medicines frequently used for interventions were pooled in the analysis and further investigated. Seventeen studies were pooled in the meta-analysis and showed that BMD was higher in the herbal medicine group than in the control group (standardized mean difference [SMD]: 0.857; 95% confidence interval [CI]: 0.412 to 1.301). Significant benefits of herbal medicine for BMD were found in the lumbar spine, femoral neck, and femoral trochanter and in postmenopausal women (SMD: 0.600, 95% CI: 0.068 to 1.131) by subgroup analysis. Moreover, through the meta-regression analysis, the age at menopause and the menopause duration were found to influence the herbal intervention effects on BMD. In addition, the most prescribed medicine among the effective herbs in the pooled studies was found to be Epimedium brevicornum Maxim. This paper provides evidence that herbal medicine interventions increase BMD more than conventional treatments in individuals with osteoporosis, especially postmenopausal women. The results of this study suggest that herbal medicines are effective for increasing BMD in individuals with osteoporosis.

A Systematic Review of the Relationship between Normal Range of Serum Thyroid-stimulating Hormone and Bone Mineral Density in the Postmenopausal Women

2021 ◽  
Author(s):  
Xiaoli Zhu ◽  
Man Li ◽  
Shugang Li ◽  
Yifei Hu
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Correlation Coefficient ◽  
Bone Mineral ◽  
Meta Analysis ◽  
Thyroid Stimulating Hormone ◽  
Control Group ◽  
Mineral Density ◽  
Normal Range ◽  
The Relationship

Abstract Objective Considering the fact that the relationship between serum thyroid-stimulating hormone and bone mineral density in postmenopausal women is still controversial, this study adopts meta-analysis in evaluating the correlation between TSH and BMD, as well as osteoporosis in the postmenopausal women with normal thyroid function. Methods Cochrane Library, PubMed, VIP, Web of Science, Wan Fang Data, and CNKI databases were searched for articles concerning correlation between TSH and BMD in postmenopausal women. The retrieval time was set from the date of database establishment to November 30, 2020. Revman5.3 and Stata12.0 software were used for meta-analysis. Results A total of 19 articles were incorporated, including 9 articles describing the correlation coefficient (r) between TSH and BMD covering 2,573 subjects; 10 articles reflecting the risk of OP and TSH with 21,387 subjects in total; 4 articles that included in the study reflecting the mean BMD with 1,310 individuals. The Summary Fisher’ Z of the correlation between TSH and BMD was 0.16, 95% CI (0.00, 0.32), and the correlation coefficient of Summary Fisher’ Z conversion was 0.158. Study on the relationship between TSH and osteoporosis based on OR demonstrated that the combined OR was 1.76, 95% CI (1.27, 2.45), P<0.05. The BMD of group with low TSH was lower than that of the control group, SMD at -0.31, 95% CI (-0.44, -0.18), P<0.001. The BMD of group with high TSH was higher than that of the control group, SMD at 0.22, 95% CI (0.08, 0.35), P=0.001. The subgroup analyzing results displayed that the risk of osteoporosis of the subjects from community with low TSH was 1.89, 95% CI (1.43, 2.49), P<0.01. The risk of osteoporosis for subjects with low TSH and from hospitals was 1.36, 95% CI (0.46, 3.99), P=0.58; 1.84 for subjects with low TSH and anti-osteoporosis drugs, 95% CI (1.05, 3.22), P=0.03; and 1.74 for those with low TSH but not taking anti-osteoporosis drugs, 95% CI (1.08, 2.82), P=0.02. The dose-response relationship showed that the risk of osteoporosis tended to decrease when TSH was more than 2.5mIu/L. Conclusion The serum TSH is positively related with BMD in postmenopausal women, and high TSH (>2.5 mIu/L) within the normal range is possibly helpful to decrease the risk of osteoporosis in postmenopausal women.

scholarly journals Retraction Note: Associations between VDR Gene Polymorphisms and Osteoporosis Risk and Bone Mineral Density in Postmenopausal Women: A systematic review and Meta-Analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Liang Zhang ◽  
Xin Yin ◽  
Jingcheng Wang ◽  
Daolinag Xu ◽  
Yongxiang Wang ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Systematic Review ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Mineral Density ◽  
Vdr Gene ◽  
Vdr Gene Polymorphisms ◽  
Osteoporosis Risk

Editor's Note: this Article has been retracted; the Retraction Note is available at https://doi.org/10.1038/s41598-021-88654-1.

scholarly journals Effect of Denosumab on Bone Mineral Density and Markers of Bone Turnover among Postmenopausal Women with Osteoporosis

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
A. Sánchez ◽  
L. R. Brun ◽  
H. Salerni ◽  
P. R. Costanzo ◽  
D. González ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Control Group ◽  
Bone Resorption Marker ◽  
Similar Response ◽  
Mineral Density ◽  
Turnover Markers

The aim of this study was to evaluate the effect of denosumab (Dmab) on bone mineral density (BMD) and bone turnover markers after 1 year of treatment. Additionally, the effect of Dmab in bisphosphonate-naïve patients (BP-naïve) compared to patients previously treated with bisphosphonates (BP-prior) was analyzed. This retrospective study included 425 postmenopausal women treated with Dmab for 1 year in clinical practice conditions in specialized centers from Argentina. Participants were also divided according to previous bisphosphonate treatment into BP-naïve and BP-prior. A control group of patients treated with BP not switched to Dmab matched by sex, age, and body mass index was used. Data are expressed as mean ± SEM. After 1 year of treatment with Dmab the bone formation markers total alkaline phosphatase and osteocalcin were significantly decreased (23.36% and 43.97%, resp.), as was the bone resorption marker s-CTX (69.61%). Significant increases in BMD were observed at the lumbar spine, femoral neck, and total hip without differences between BP-naïve and BP-prior. A better BMD response was found in BP-prior group compared with BP treated patients not switched to Dmab.Conclusion. Dmab treatment increased BMD and decreased bone turnover markers in the whole group, with similar response in BP-naïve and BP-prior patients. A better BMD response in BP-prior patients versus BP treated patients not switched to Dmab was observed.

scholarly journals Bone mineral density status and the need for anti-osteoporotic therapy in postmenopausal women with systemic scleroderma

2019 ◽  
pp. 72-79
Author(s):  
O. V. Dobrovolskaya ◽  
N. V. Demin ◽  
A. V. Smirnov ◽  
N. V. Toroptsova
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Systemic Scleroderma ◽  
Control Group ◽  
Inflammatory Rheumatic Diseases ◽  
Mineral Density ◽  
Buffer Solution ◽  
Identification Of Persons ◽  
The One

The article is devoted to the study of bone mineral density in patients with systemic scleroderma (SSD) and the identification of persons, who needs the anti-osteoporotic treatment. A total of 170 postmenopausal women were examined: 103 patients with SSD and 67 patients without inflammatory rheumatic diseases. Osteoporosis (OP) was detected in 49.5% in the patient group and in 31% in the control group (p <0.05). The correlation relation between the bone mineral density (BMD) and body mass index was found to be direct, and the one between BMD and the duration of the disease and the cumulative dose of glucocorticoids was found to be inverse. The blood vitamin D level (25(OH)D) was significantly lower in patients than in controls (19.3 ± 7.4 ng/ml and 23.3 ± 8.6 ng/ml, respectively), and among individuals with SSD it was significantly lower in patients with OP than in patients without OP (p <0.05). 85% examined patients with SSD needed the anti-osteoporotic therapy. Treatment with the generic alendronate in the form of effervescent tablets to prepare Binosto buffer solution was effective and safe in patients with SSD with esophageal hypotension.

scholarly journals Effects of Different Types of Exercise on Bone Mineral Density in Postmenopausal Women: A Systematic Review and Meta-analysis

2020 ◽  
Vol 107 (5) ◽  
pp. 409-439
Author(s):  
Wolfgang Kemmler ◽  
Mahdieh Shojaa ◽  
Matthias Kohl ◽  
Simon von Stengel
Keyword(s):  
Bone Mineral Density ◽  
Systematic Review ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Meta Analysis ◽  
Favorable Effect ◽  
Mineral Density ◽  
Mixed Effect ◽  
Different Types ◽  
Type Of Exercise

Abstract In this sub-analysis of a comprehensive meta-analysis, we aimed to determine the effect of different types of exercise on (areal) bone mineral density (BMD) in postmenopausal women. A systematic review of the literature according to the PRISMA statement included (a) controlled trials, (b) with at least one exercise and one control group, (c) intervention ≥ 6 months, (d) BMD assessments at lumbar spine (LS), femoral neck (FN) or total hip (TH), (e) in postmenopausal women. Eight electronic databases were scanned without language restrictions up to March 2019. The present subgroup analysis was conducted as a mixed-effect meta-analysis with “type of exercise” as the moderator. The 84 eligible exercise groups were classified into (a) weight bearing (WB, n = 30) exercise, (b) (dynamic) resistance exercise (DRT, n = 18), (c) mixed WB&DRT interventions (n = 36). Outcome measures were standardized mean differences (SMD) for BMD-changes at LS, FN and TH. All types of exercise significantly affect BMD at LS, FN and TH. SMD for LS average 0.40 (95% CI 0.15–0.65) for DRT, SMD 0.26 (0.03–0.49) for WB and SMD 0.42 (0.23–0.61) for WB&DRT. SMD for FN were 0.27 (0.09–0.45) for DRT, 0.37 (0.12–0.62) for WB and 0.35 (0.19–0.51) for WB&DRT. Lastly, SMD for TH changes were 0.51 (0.28–0.74) for DRT, 0.40 (0.21–0.58) for WB and 0.34 (0.14–0.53) for WB&DRT. In summary, we provided further evidence for the favorable effect of exercise on BMD largely independent of the type of exercise. However, in order to generate dedicated exercise recommendations or exercise guideline, meta-analyses might be a too rough tool.

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