Photophysical properties of sinoporphyrin sodium and explanation of its high photo-activity

2017 ◽  
Vol 21 (01) ◽  
pp. 59-66 ◽  
Author(s):  
Lixin Zang ◽  
Huimin Zhao ◽  
Qicheng Fang ◽  
Ming Fan ◽  
Tong Chen ◽  
...  
Keyword(s):  
Quantum Yield ◽  
Singlet Oxygen ◽  
Extinction Coefficient ◽  
Photophysical Properties ◽  
Generation Efficiency ◽  
High Brightness ◽  
Extinction Coefficients ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Yield Formula

Sinoporphyrin sodium (DVDMS) is a novel photosensitizer with high photodynamic therapy (PDT) effect. Reasons for its high photo-activity were investigated according to the study of photophysical characteristics of DVDMS. Extinction coefficients ([Formula: see text] of DVDMS at 405 nm and 630 nm are 4.36 × 105 and 1.84 × 104 M[Formula: see text].cm[Formula: see text]; fluorescence quantum yield ([Formula: see text] is 0.026; quantum yield of lowest triplet state formation is 0.94 and singlet oxygen quantum yield ([Formula: see text] is 0.92. Although [Formula: see text] of DVDMS is only 10% higher than that of Photofrin[Formula: see text] (0.83), the extinction coefficient of DVDMS at 630 nm is 10-fold greater than that of Photofrin[Formula: see text]. This leads to its higher singlet oxygen generation efficiency ([Formula: see text]. The higher [Formula: see text] of DVDMS can result in an effective reduction of dosage (1/10 of Photofrin[Formula: see text] reaching the same cytotoxic effect as Photofrin[Formula: see text]. Even though [Formula: see text] is approximately equal to that of Photofrin[Formula: see text], brightness ([Formula: see text] of DVDMS is 10-fold greater than that of Photofrin[Formula: see text] because of the 10-fold greater extinction coefficient. Thus, fluorescence diagnosis ability of 0.2 mg/kg DVDMS is comparable to that of 2 mg/kg Photofrin[Formula: see text] used in PDT. Overall, the 10-fold greater extinction coefficients are responsible for the high brightness and singlet oxygen generation efficiency of DVDMS.

Photophysical properties, singlet oxygen generation efficiency and cytotoxic effects of aloe emodin as a blue light photosensitizer for photodynamic therapy in dermatological treatment

2017 ◽  
Vol 16 (7) ◽  
pp. 1088-1094 ◽  
Author(s):  
Lixin Zang ◽  
Huimin Zhao ◽  
Xueyu Ji ◽  
Wenwu Cao ◽  
Zhiguo Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Blue Light ◽  
Photophysical Properties ◽  
Generation Efficiency ◽  
Cytotoxic Effects ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Aloe Emodin

Aloe emodin with anticancer and photosensitising capabilities, excited by blue light, is proposed as a photosensitizer to treat superficial diseases.

scholarly journals Сравнительные исследования фотофизических свойств димегина, фотодитазина и радахлорина

2019 ◽  
Vol 126 (2) ◽  
pp. 162
Author(s):  
И.В. Багров ◽  
А.В. Дадеко ◽  
В.М. Киселев ◽  
Т.Д. Муравьева ◽  
А.М. Стародубцев
Keyword(s):  
Quantum Yield ◽  
Singlet Oxygen ◽  
Fluorescence Quantum Yield ◽  
Photophysical Properties ◽  
Quantum Yields ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

AbstractThe photophysical properties of three photosensitizers—dimegine, photoditazine, and radachlorin—have been comparatively examined. For dimegine and photoditazine, two techniques have been used to measure the singlet oxygen generation quantum yields and the quenching constants of singlet oxygen by dimegine and photoditazine, as well as the dimegine fluorescence quantum yield.

Novel BODIPY-Cyclotriphosphazene- Fullerene triads: Synthesis, characterization and singlet oxygen generation efficiency

2018 ◽  
Vol 153 ◽  
pp. 26-34 ◽  
Author(s):  
Semiha Yıldırım Sarıkaya ◽  
Serkan Yeşilot ◽  
Adem Kılıç ◽  
Elif Okutan
Keyword(s):  
Singlet Oxygen ◽  
Generation Efficiency ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

Photophysical Properties and Singlet Oxygen Generation of Three Sets of Halogenated Corroles

2012 ◽  
Vol 116 (49) ◽  
pp. 14228-14234 ◽  
Author(s):  
Wenli Shao ◽  
Hui Wang ◽  
Shuang He ◽  
Lei Shi ◽  
Kaimei Peng ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Photophysical Properties ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

The main strategies for tuning BODIPY fluorophores into photosensitizers

2020 ◽  
Vol 24 (05n07) ◽  
pp. 603-635 ◽  
Author(s):  
Jun Wang ◽  
Qingbao Gong ◽  
Long Wang ◽  
Erhong Hao ◽  
Lijuan Jiao
Keyword(s):  
Singlet Oxygen ◽  
Fluorescent Dyes ◽  
Malignant Tumors ◽  
Therapeutic Agents ◽  
Invasive Technique ◽  
Generation Efficiency ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Cancer Tumor ◽  
Dual Imaging

Photodynamic therapy (PDT) is a minimally invasive technique for the treatment of target malignant tumors via the generation of highly reactive singlet oxygen species. PDT treatment of cancer/tumor tissues greatly relies on the development of suitable stable, highly specific and efficient photosensitizers. BODIPY (Boron dipyrromethene) derivatives, as a class of well-developed, versatile fluorescent dyes, has emerged as a new class of PDT agents over the past decade. Many elegant strategies have been developed to enhance the singlet oxygen generation efficiency and the cancer/tumor cell selectivity of BODIPY-based photosensitizers to improve the therapeutic outcomes as well as to minimize the side effects. Many of the currently reported BODIPY-based photosensitizers are valuable dual imaging and therapeutic agents, which can efficiently generate singlet oxygen for PDT and emit fluorescence for in vivo imaging. Although the currently approved PDT agents used for clinical trials do not feature BODIPYs, this situation is expected to change. In this review, we provide an overview of the various strategies that have been used to improve the singlet oxygen generation efficiency for tuning BODIPY fluorophores into photosensitizers and dual imaging/therapeutic agents. Their photophysical properties and photocytotoxic activity including the absorption/emission wavelengths, the singlet oxygen generation efficiency ([Formula: see text] and the half maximal inhibitory concentration [Formula: see text] of these currently reported photosensitizers are summarized. We believe these newly developed BODIPY-based photosensitizers will broaden current concepts of strategies for PDT agent design, and promise to make an important contribution to the diagnosis and therapeutics for the treatment of cancer.

Rigid axially symmetrical C60-BODIPY triplet photosensitizers: effect of bridge length on singlet oxygen generation

2020 ◽  
Vol 44 (46) ◽  
pp. 20419-20427
Author(s):  
San-E Zhu ◽  
Jianhui Zhang ◽  
Lifeng Dou ◽  
Na Li ◽  
Kunhong Hu ◽  
...  
Keyword(s):  
Quantum Yield ◽  
Singlet Oxygen ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Bridge Length

Two rigid axially symmetrical C60-BODIPY systems with different bridge lengths have been synthesized and the dyad with short bridge generates a higher quantum yield of singlet oxygen.

scholarly journals Out-of-Plane Coordinated Porphyrin Nanotubes with Enhanced Singlet Oxygen Generation Efficiency

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Qiang Zhao ◽  
Yao Wang ◽  
Yanshuang Xu ◽  
Yun Yan ◽  
Jianbin Huang
Keyword(s):  
Singlet Oxygen ◽  
Generation Efficiency ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Out Of Plane
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