Photophysical properties, singlet oxygen generation efficiency and cytotoxic effects of aloe emodin as a blue light photosensitizer for photodynamic therapy in dermatological treatment

2017 ◽  
Vol 16 (7) ◽  
pp. 1088-1094 ◽  
Author(s):  
Lixin Zang ◽  
Huimin Zhao ◽  
Xueyu Ji ◽  
Wenwu Cao ◽  
Zhiguo Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Blue Light ◽  
Photophysical Properties ◽  
Generation Efficiency ◽  
Cytotoxic Effects ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Aloe Emodin

Aloe emodin with anticancer and photosensitising capabilities, excited by blue light, is proposed as a photosensitizer to treat superficial diseases.

Photophysical properties of sinoporphyrin sodium and explanation of its high photo-activity

2017 ◽  
Vol 21 (01) ◽  
pp. 59-66 ◽  
Author(s):  
Lixin Zang ◽  
Huimin Zhao ◽  
Qicheng Fang ◽  
Ming Fan ◽  
Tong Chen ◽  
...  
Keyword(s):  
Quantum Yield ◽  
Singlet Oxygen ◽  
Extinction Coefficient ◽  
Photophysical Properties ◽  
Generation Efficiency ◽  
High Brightness ◽  
Extinction Coefficients ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Yield Formula

Sinoporphyrin sodium (DVDMS) is a novel photosensitizer with high photodynamic therapy (PDT) effect. Reasons for its high photo-activity were investigated according to the study of photophysical characteristics of DVDMS. Extinction coefficients ([Formula: see text] of DVDMS at 405 nm and 630 nm are 4.36 × 105 and 1.84 × 104 M[Formula: see text].cm[Formula: see text]; fluorescence quantum yield ([Formula: see text] is 0.026; quantum yield of lowest triplet state formation is 0.94 and singlet oxygen quantum yield ([Formula: see text] is 0.92. Although [Formula: see text] of DVDMS is only 10% higher than that of Photofrin[Formula: see text] (0.83), the extinction coefficient of DVDMS at 630 nm is 10-fold greater than that of Photofrin[Formula: see text]. This leads to its higher singlet oxygen generation efficiency ([Formula: see text]. The higher [Formula: see text] of DVDMS can result in an effective reduction of dosage (1/10 of Photofrin[Formula: see text] reaching the same cytotoxic effect as Photofrin[Formula: see text]. Even though [Formula: see text] is approximately equal to that of Photofrin[Formula: see text], brightness ([Formula: see text] of DVDMS is 10-fold greater than that of Photofrin[Formula: see text] because of the 10-fold greater extinction coefficient. Thus, fluorescence diagnosis ability of 0.2 mg/kg DVDMS is comparable to that of 2 mg/kg Photofrin[Formula: see text] used in PDT. Overall, the 10-fold greater extinction coefficients are responsible for the high brightness and singlet oxygen generation efficiency of DVDMS.

Design of Novel Photosensitizers and Controlled Singlet Oxygen Generation for Photodynamic Therapy

2021 ◽  
Author(s):  
Esra Tanrıverdi Eçik ◽  
Onur BULUT ◽  
Hasan Hüseyin Kazan ◽  
Elif Şenkuytu ◽  
Bunyemin Cosut
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Side Effect ◽  
Side Effect Profile ◽  
High Ability ◽  
Lower Side ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Promising Strategy

Photodynamic therapy (PDT) is a promising strategy in cancer treatment with its relatively lower side effect profile. Undoubtedly, the key component of PDT is the photosensitizers with a high ability...

Biodegradable Nano-photosensitizer with Photoactivatable Singlet Oxygen Generation for Synergistic Phototherapy

2021 ◽  
Author(s):  
Jiaxin Shen ◽  
Dandan Chen ◽  
Ye Liu ◽  
Guoyang Gao ◽  
Zhihe Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Promising Method ◽  
Normal Cells ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Nir Light

Photodynamic therapy (PDT) is a promising method for cancer therapy and also may initiate unexpected damages to normal cells and tissues. Herein, we developed a near-infrared (NIR) light-activatable nanophotosensitizer, which...

scholarly journals Correction: Efficient singlet oxygen generation from sugar pendant C60 derivatives for photodynamic therapy

2015 ◽  
Vol 51 (99) ◽  
pp. 17631-17632 ◽  
Author(s):  
Shigenobu Yano ◽  
Masami Naemura ◽  
Akio Toshimitsu ◽  
Motofusa Akiyama ◽  
Atsushi Ikeda ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
C60 Derivatives

Correction for ‘Efficient singlet oxygen generation from sugar pendant C60 derivatives for photodynamic therapy’ by Shigenobu Yano et al., Chem. Commun., 2015, DOI: 10.1039/c5cc07353g.

Novel BODIPY-Cyclotriphosphazene- Fullerene triads: Synthesis, characterization and singlet oxygen generation efficiency

2018 ◽  
Vol 153 ◽  
pp. 26-34 ◽  
Author(s):  
Semiha Yıldırım Sarıkaya ◽  
Serkan Yeşilot ◽  
Adem Kılıç ◽  
Elif Okutan
Keyword(s):  
Singlet Oxygen ◽  
Generation Efficiency ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation
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