Study of an epidemic model with Z-type control

2018 ◽  
Vol 11 (07) ◽  
pp. 1850084 ◽  
Author(s):  
Sudip Samanta
Keyword(s):  
Epidemic Model ◽  
Control Mechanism ◽  
Basin Of Attraction ◽  
Endemic Equilibrium ◽  
Successful Implementation ◽  
Asymptotically Stable ◽  
Infectious Disease Outbreak ◽  
Globally Asymptotically Stable ◽  
The Stability ◽  
Disease Free

In the present paper, an epidemic model with Z-type control mechanism has been proposed and analyzed to explore the disease control strategy on an infectious disease outbreak. The uncontrolled model can have a disease-free equilibrium and an endemic equilibrium. The expression of the basic reproduction number and the conditions for the stability of the equilibria are derived. It is also observed that the disease-free equilibrium is globally asymptotically stable if [Formula: see text], whereas the endemic equilibrium is globally asymptotically stable if [Formula: see text]. The model is further improved by considering Z-control mechanism and investigated. Disease can be controlled by using Z-control while the basic reproduction of the uncontrolled system is greater than unity. The positivity conditions of the solutions are derived and the basin of attraction for successful implementation of Z-control mechanism is also investigated. To verify the analytical findings, extensive numerical simulations on the model are carried out.

STABILITY OF AN AGE-STRUCTURED SEIS EPIDEMIC MODEL WITH INFECTIVITY IN INCUBATIVE PERIOD

2010 ◽  
Vol 03 (03) ◽  
pp. 299-312 ◽  
Author(s):  
SHU-MIN GUO ◽  
XUE-ZHI LI ◽  
XIN-YU SONG
Keyword(s):  
Epidemic Model ◽  
Reproduction Number ◽  
Endemic Equilibrium ◽  
Stability Conditions ◽  
Asymptotically Stable ◽  
Globally Asymptotically Stable ◽  
Age Structured ◽  
The Stability ◽  
Disease Free ◽  
The Basic Reproduction Number

In this paper, an age-structured SEIS epidemic model with infectivity in incubative period is formulated and studied. The explicit expression of the basic reproduction number R0 is obtained. It is shown that the disease-free equilibrium is globally asymptotically stable if R0 < 1, at least one endemic equilibrium exists if R0 > 1. The stability conditions of endemic equilibrium are also given.

Stability analysis and optimal control of an epidemic model with vaccination

2015 ◽  
Vol 08 (03) ◽  
pp. 1550030 ◽  
Author(s):  
Swarnali Sharma ◽  
G. P. Samanta
Keyword(s):  
Optimal Control ◽  
Stability Analysis ◽  
Epidemic Model ◽  
Asymptotically Stable ◽  
Control Pair ◽  
Globally Asymptotically Stable ◽  
The Stability ◽  
The Cost ◽  
Objective Functional ◽  
Disease Free

In this paper, we have developed a compartment of epidemic model with vaccination. We have divided the total population into five classes, namely susceptible, exposed, infective, infective in treatment and recovered class. We have discussed about basic properties of the system and found the basic reproduction number (R0) of the system. The stability analysis of the model shows that the system is locally as well as globally asymptotically stable at disease-free equilibrium E0when R0< 1. When R0> 1 endemic equilibrium E1exists and the system becomes locally asymptotically stable at E1under some conditions. We have also discussed the epidemic model with two controls, vaccination control and treatment control. An objective functional is considered which is based on a combination of minimizing the number of exposed and infective individuals and the cost of the vaccines and drugs dose. Then an optimal control pair is obtained which minimizes the objective functional. Our numerical findings are illustrated through computer simulations using MATLAB. Epidemiological implications of our analytical findings are addressed critically.

scholarly journals Global Dynamics of an SIQR Model with Vaccination and Elimination Hybrid Strategies

Mathematics ◽  
2018 ◽  
Vol 6 (12) ◽  
pp. 328 ◽  
Author(s):  
Yanli Ma ◽  
Jia-Bao Liu ◽  
Haixia Li
Keyword(s):  
Lyapunov Function ◽  
Basic Reproduction Number ◽  
Epidemic Model ◽  
Reproduction Number ◽  
Endemic Equilibrium ◽  
Global Dynamics ◽  
Asymptotically Stable ◽  
Globally Asymptotically Stable ◽  
Disease Free ◽  
The Basic Reproduction Number

In this paper, an SIQR (Susceptible, Infected, Quarantined, Recovered) epidemic model with vaccination, elimination, and quarantine hybrid strategies is proposed, and the dynamics of this model are analyzed by both theoretical and numerical means. Firstly, the basic reproduction number R 0 , which determines whether the disease is extinct or not, is derived. Secondly, by LaSalles invariance principle, it is proved that the disease-free equilibrium is globally asymptotically stable when R 0 < 1 , and the disease dies out. By Routh-Hurwitz criterion theory, we also prove that the disease-free equilibrium is unstable and the unique endemic equilibrium is locally asymptotically stable when R 0 > 1 . Thirdly, by constructing a suitable Lyapunov function, we obtain that the unique endemic equilibrium is globally asymptotically stable and the disease persists at this endemic equilibrium if it initially exists when R 0 > 1 . Finally, some numerical simulations are presented to illustrate the analysis results.

SVIR epidemic model with age structure in susceptibility, vaccination effects and relapse

2017 ◽  
Vol 82 (5) ◽  
pp. 945-970 ◽  
Author(s):  
Jinliang Wang ◽  
Min Guo ◽  
Shengqiang Liu
Keyword(s):  
Age Structure ◽  
Epidemic Model ◽  
Lyapunov Functional ◽  
Basic Reproductive Number ◽  
Reproductive Number ◽  
Combined Effects ◽  
Asymptotically Stable ◽  
Globally Asymptotically Stable ◽  
The Stability ◽  
Disease Free

Abstract An SVIR epidemic model with continuous age structure in the susceptibility, vaccination effects and relapse is proposed. The asymptotic smoothness, existence of a global attractor, the stability of equilibria and persistence are addressed. It is shown that if the basic reproductive number $\Re_0&lt;1$, then the disease-free equilibrium is globally asymptotically stable. If $\Re_0&gt;1$, the disease is uniformly persistent, and a Lyapunov functional is used to show that the unique endemic equilibrium is globally asymptotically stable. Combined effects of susceptibility age, vaccination age and relapse age on the basic reproductive number are discussed.

scholarly journals Partial Differential Equations of an Epidemic Model with Spatial Diffusion

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
El Mehdi Lotfi ◽  
Mehdi Maziane ◽  
Khalid Hattaf ◽  
Noura Yousfi
Keyword(s):  
Basic Reproduction Number ◽  
Epidemic Model ◽  
Reproduction Number ◽  
Reaction Diffusion ◽  
Endemic Equilibrium ◽  
Asymptotically Stable ◽  
Sir Epidemic Model ◽  
Globally Asymptotically Stable ◽  
Disease Free ◽  
The Basic Reproduction Number

The aim of this paper is to study the dynamics of a reaction-diffusion SIR epidemic model with specific nonlinear incidence rate. The global existence, positivity, and boundedness of solutions for a reaction-diffusion system with homogeneous Neumann boundary conditions are proved. The local stability of the disease-free equilibrium and endemic equilibrium is obtained via characteristic equations. By means of Lyapunov functional, the global stability of both equilibria is investigated. More precisely, our results show that the disease-free equilibrium is globally asymptotically stable if the basic reproduction number is less than or equal to unity, which leads to the eradication of disease from population. When the basic reproduction number is greater than unity, then disease-free equilibrium becomes unstable and the endemic equilibrium is globally asymptotically stable; in this case the disease persists in the population. Numerical simulations are presented to illustrate our theoretical results.

GLOBAL STABILITY IN A TUBERCULOSIS MODEL INCORPORATING TWO LATENT PERIODS

2009 ◽  
Vol 02 (03) ◽  
pp. 357-362 ◽  
Author(s):  
LUJU LIU
Keyword(s):  
Latent Period ◽  
Reproduction Number ◽  
Endemic Equilibrium ◽  
Asymptotically Stable ◽  
Short Term ◽  
Globally Asymptotically Stable ◽  
Tuberculosis Model ◽  
The Stability ◽  
Disease Free

A tuberculosis (TB) model with two latent periods, short-term latent period (E1) and long-term latent period (E2), and fast and slow progressions is analyzed. The stability of the unique endemic equilibrium of the model is proved. It turns out that the disease-free equilibrium is globally asymptotically stable if the basic reproduction number R0 ≤ 1, and the endemic equilibrium is globally asymptotically stable if R0 > 1.

scholarly journals Mathematical Modelling on Double Quarantine Process in the Spread and Stability of Covid-19

2020 ◽  
Author(s):  
Jangyadatta Behera ◽  
Aswin Kumar Rauta ◽  
Yerra Shankar Rao ◽  
Sairam Patnaik
Keyword(s):  
Basic Reproduction Number ◽  
Reproduction Number ◽  
Equilibrium Points ◽  
Endemic Equilibrium ◽  
Asymptotically Stable ◽  
Globally Asymptotically Stable ◽  
Analytical Result ◽  
The Stability ◽  
The Impact ◽  
Disease Free

Abstract In this paper, a mathematical model is proposed on the spread and control of corona virus disease2019 (COVID19) to ascertain the impact of pre quarantine for suspected individuals having travel history ,immigrants and new born cases in the susceptible class following the lockdown or shutdown rules and adopted the post quarantine process for infected class. Set of nonlinear ordinary differential equations (ODEs) are generated and parameters like natural mortality rate, rate of COVID-19 induced death, rate of immigrants, rate of transmission and recovery rate are integrated in the scheme. A detailed analysis of this model is conducted analytically and numerically. The local and global stability of the disease is discussed mathematically with the help of Basic Reproduction Number. The ODEs are solved numerically with the help of Runge-Kutta 4th order method and graphs are drawn using MATLAB software to validate the analytical result with numerical simulation. It is found that both results are in good agreement with the results available in the existing literatures. The stability analysis is performed for both disease free equilibrium and endemic equilibrium points. The theorems based on Routh-Hurwitz criteria and Lyapunov function are proved .It is found that the system is locally asymptotically stable at disease free and endemic equilibrium points for basic reproduction number less than one and globally asymptotically stable for basic reproduction number greater than one. Finding of this study suggest that COVID-19 would remain pandemic with the progress of time but would be stable in the long-term if the pre and post quarantine policy for asymptomatic and symptomatic individuals are implemented effectively followed by social distancing, lockdown and containment.

Global stability of SEIVR epidemic model with generalized incidence and preventive vaccination

2015 ◽  
Vol 08 (06) ◽  
pp. 1550082 ◽  
Author(s):  
Muhammad Altaf Khan ◽  
Yasir Khan ◽  
Qaiser Badshah ◽  
Saeed Islam
Keyword(s):  
Basic Reproduction Number ◽  
Epidemic Model ◽  
Reproduction Number ◽  
Endemic Equilibrium ◽  
Asymptotically Stable ◽  
Globally Asymptotically Stable ◽  
Number Formula ◽  
Preventive Vaccination ◽  
Disease Free ◽  
The Basic Reproduction Number

In this paper, an SEIVR epidemic model with generalized incidence and preventive vaccination is considered. First, we formulate the model and obtain its basic properties. Then, we find the equilibrium points of the model, the disease-free and the endemic equilibrium. The stability of disease-free and endemic equilibrium is associated with the basic reproduction number [Formula: see text]. If the basic reproduction number [Formula: see text], the disease-free equilibrium is locally as well as globally asymptotically stable. Moreover, if the basic reproduction number [Formula: see text], the disease is uniformly persistent and the unique endemic equilibrium of the system is locally as well as globally asymptotically stable under certain conditions. Finally, the numerical results justify the analytical results.

scholarly journals Analysis of an SEIS Epidemic Model with a Changing Delitescence

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Jinghai Wang
Keyword(s):  
Epidemic Model ◽  
Endemic Equilibrium ◽  
Asymptotically Stable ◽  
Globally Asymptotically Stable ◽  
Globally Stable ◽  
Disease Free

An SEIS epidemic model with a changing delitescence is studied. The disease-free equilibrium and the endemic equilibrium of the model are studied as well. It is shown that the disease-free equilibrium is globally stable under suitable conditions. Moreover, we also show that the unique endemic equilibrium of the system is globally asymptotically stable under certain conditions.

scholarly journals On a Discrete SEIR Epidemic Model with Exposed Infectivity, Feedback Vaccination and Partial Delayed Re-Susceptibility

Mathematics ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 520
Author(s):  
Manuel De la Sen ◽  
Santiago Alonso-Quesada ◽  
Asier Ibeas
Keyword(s):  
Equilibrium Point ◽  
Epidemic Model ◽  
Transmission Rate ◽  
Equilibrium Points ◽  
Endemic Equilibrium ◽  
Asymptotically Stable ◽  
Globally Asymptotically Stable ◽  
Control Gain ◽  
Disease Free ◽  
Partial Immunity

A new discrete Susceptible-Exposed-Infectious-Recovered (SEIR) epidemic model is proposed, and its properties of non-negativity and (both local and global) asymptotic stability of the solution sequence vector on the first orthant of the state-space are discussed. The calculation of the disease-free and the endemic equilibrium points is also performed. The model has the following main characteristics: (a) the exposed subpopulation is infective, as it is the infectious one, but their respective transmission rates may be distinct; (b) a feedback vaccination control law on the Susceptible is incorporated; and (c) the model is subject to delayed partial re-susceptibility in the sense that a partial immunity loss in the recovered individuals happens after a certain delay. In this way, a portion of formerly recovered individuals along a range of previous samples is incorporated again to the susceptible subpopulation. The rate of loss of partial immunity of the considered range of previous samples may be, in general, distinct for the various samples. It is found that the endemic equilibrium point is not reachable in the transmission rate range of values, which makes the disease-free one to be globally asymptotically stable. The critical transmission rate which confers to only one of the equilibrium points the property of being asymptotically stable (respectively below or beyond its value) is linked to the unity basic reproduction number and makes both equilibrium points to be coincident. In parallel, the endemic equilibrium point is reachable and globally asymptotically stable in the range for which the disease-free equilibrium point is unstable. It is also discussed the relevance of both the vaccination effort and the re-susceptibility level in the modification of the disease-free equilibrium point compared to its reached component values in their absence. The influences of the limit control gain and equilibrium re-susceptibility level in the reached endemic state are also explicitly made viewable for their interpretation from the endemic equilibrium components. Some simulation examples are tested and discussed by using disease parameterizations of COVID-19.

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