A new distributed feature selection technique for classifying gene expression data

2019 ◽  
Vol 12 (04) ◽  
pp. 1950039 ◽  
Author(s):  
Sarah M. Ayyad ◽  
Ahmed I. Saleh ◽  
Labib M. Labib

Classification of gene expression data is a pivotal research area that plays a substantial role in diagnosis and prediction of diseases. Generally, feature selection is one of the extensively used techniques in data mining approaches, especially in classification. Gene expression data are usually composed of dozens of samples characterized by thousands of genes. This increases the dimensionality coupled with the existence of irrelevant and redundant features. Accordingly, the selection of informative genes (features) becomes difficult, which badly affects the gene classification accuracy. In this paper, we consider the feature selection for classifying gene expression microarray datasets. The goal is to detect the most possibly cancer-related genes in a distributed manner, which helps in effectively classifying the samples. Initially, the available huge amount of considered features are subdivided and distributed among several processors. Then, a new filter selection method based on a fuzzy inference system is applied to each subset of the dataset. Finally, all the resulted features are ranked, then a wrapper-based selection method is applied. Experimental results showed that our proposed feature selection technique performs better than other techniques since it produces lower time latency and improves classification performance.

Microarray technology has been developed as one of the powerful tools that have attracted many researchers to analyze gene expression level for a given organism. It has been observed that gene expression data have very large (in terms of thousands) of features and less number of samples (in terms of hundreds). This characteristic makes difficult to do an analysis of gene expression data. Hence efficient feature selection technique must be applied before we go for any kind of analysis. Feature selection plays a vital role in the classification of gene expression data. There are several feature selection techniques have been induced in this field. But Support Vector Machine with Recursive Feature Elimination (SVM-RFE) has been proven as the promising feature selection methods among others. SVM-RFE ranks the genes (features) by training the SVM classification model and with the combination of RFE method key genes are selected. Huge time consumption is the main issue of SVM-RFE. We introduced an efficient implementation of linier SVM to overcome this problem and improved the RFE with variable step size. Then, combined method was used for selecting informative genes. Effective resampling method is proposed to preprocess the datasets. This is used to make the distribution of samples balanced, which gives more reliable classification results. In this paper, we have also studied the applicability of common classifiers. Detailed experiments are conducted on four commonly used microarray gene expression datasets. The results show that the proposed method comparable classification performance


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