Cardiovascular Control by Cholinergic Mechanisms in the Central Nervous System

1982 ◽  
Vol 22 (1) ◽  
pp. 341-381 ◽  
Author(s):  
H E Brezenoff ◽  
R Giuliano
1995 ◽  
Vol 83 (5) ◽  
pp. 1082-1089 ◽  
Author(s):  
Takahiko Kamibayashi ◽  
Tadanori Mammoto ◽  
Yukio Hayashi ◽  
Atsushi Yamatodani ◽  
Koji Takada ◽  
...  

Abstract Background alpha2Adrenoceptors in the central nervous system mediate various physiologic processes, including cardiovascular control. Recently, some of these actions have been reported to be mediated by a nonadrenergic receptor, namely an imidazoline receptor. The authors previously reported that dexmedetomidine, a selective alpha2agonist, prevents the genesis of halothane-epinephrine dysrhythmias through a central mechanism. Because dexmedetomidine also binds to imidazoline receptors, we performed the current study to examine the precise receptor mechanism involved in the antidysrhythmic property of dexmedetomidine.


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