Preoperative Assessment of Pancreatic Cancer with FDG PET/MR Imaging versus FDG PET/CT Plus Contrast-enhanced Multidetector CT: A Prospective Preliminary Study

PurposeThis study aims to determine the diagnostic performance of whole-body FDG PET/CT plus delayed abdomen PET/MR imaging in the pretherapeutic assessment of pancreatic cancer in comparison with that of contrast-enhanced (CE)-CT/MR imaging.Materials and MethodsForty patients with pancreatic cancer underwent nonenhanced whole-body FDG PET/CT, delayed abdomen PET/MR imaging, and CE-CT/MR imaging. Two nuclear medicine physicians independently reviewed these images and discussed to reach a consensus, determining tumor resectability according to a 5-point scale, N stage (N0 or N positive), and M stage (M0 or M1). With use of clinical-surgical-pathologic findings as the reference standard, diagnostic performances of the two imaging sets were compared by using the McNemar test.ResultsThe diagnostic performance of FDG PET/CT plus delayed PET/MR imaging was not significantly different from that of CE-CT/MR imaging in the assessment of tumor resectability [area under the receiver operating characteristic curve: 0.927 vs. 0.925 (p = 0.975)], N stage (accuracy: 80% (16 of 20 patients) vs. 55% (11 of 20 patients), p = 0.125), and M stage (accuracy: 100% (40 of 40 patients) vs. 93% (37 of 40 patients), p = 0.250). Moreover, 14 of 40 patients had liver metastases. The number of liver metastases detected by CE-CT/MR imaging, PET/CT, and PET/MR imaging were 33, 18, and 61, respectively. Compared with CE-CT/MR imaging, PET/MR imaging resulted in additional findings of more liver metastases in 9/14 patients, of which 3 patients were upstaged. Compared with PET/CT, PET/MR imaging resulted in additional findings of more liver metastases in 12/14 patients, of which 6 patients were upstaged.ConclusionsAlthough FDG PET/CT plus delayed PET/MR imaging showed a diagnostic performance similar to that of CE-CT/MR imaging in the pretherapeutic assessment of the resectability and staging of pancreatic tumors, it still has potential as the more efficient and reasonable work-up approach for the additional value of metastatic information provided by delayed PET/MR imaging.

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Utility of Contrast-Enhanced FDG-PET/CT in the Clinical Management of Pancreatic Cancer

Pancreas ◽

10.1097/mpa.0b013e3182550d77 ◽

2013 ◽

Vol 42 (1) ◽

pp. 11-19 ◽

Cited By ~ 71

Author(s):

Akinori Asagi ◽

Koji Ohta ◽

Junichirou Nasu ◽

Minoru Tanada ◽

Seijin Nadano ◽

...

Keyword(s):

Pancreatic Cancer ◽

Fdg Pet ◽

Clinical Management ◽

Contrast Enhanced ◽

Pet Ct ◽

Fdg Pet Ct

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Accuracy of early and delayed FDG PET-CT and of contrast-enhanced CT in the evaluation of lung nodules: a preliminary study on 30 patients

La radiologia medica ◽

10.1007/s11547-009-0400-z ◽

2009 ◽

Vol 114 (6) ◽

pp. 890-906 ◽

Cited By ~ 36

Author(s):

O. Schillaci ◽

L. Travascio ◽

F. Bolacchi ◽

F. Calabria ◽

C. Bruni ◽

...

Keyword(s):

Fdg Pet ◽

Lung Nodules ◽

Contrast Enhanced Ct ◽

Contrast Enhanced ◽

Pet Ct ◽

Enhanced Ct ◽

Preliminary Study ◽

Fdg Pet Ct

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Textural features on 18F-FDG PET/CT and dynamic contrast-enhanced MR imaging for predicting treatment response and survival of patients with hypopharyngeal carcinoma

Medicine ◽

10.1097/md.0000000000016608 ◽

2019 ◽

Vol 98 (33) ◽

pp. e16608

Author(s):

Chih-Kai Wong ◽

Sheng-Chieh Chan ◽

Shu-Hang Ng ◽

Chia-Hsun Hsieh ◽

Nai-Ming Cheng ◽

...

Keyword(s):

Mr Imaging ◽

Treatment Response ◽

Fdg Pet ◽

Hypopharyngeal Carcinoma ◽

Textural Features ◽

Dynamic Contrast Enhanced ◽

Contrast Enhanced ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Contrast-Enhanced 18F-FDG PET/CT: 1-Stop-Shop Imaging for Assessing the Resectability of Pancreatic Cancer

Journal of Nuclear Medicine ◽

10.2967/jnumed.108.051466 ◽

2008 ◽

Vol 49 (9) ◽

pp. 1408-1413 ◽

Cited By ~ 106

Author(s):

K. Strobel ◽

S. Heinrich ◽

U. Bhure ◽

J. Soyka ◽

P. Veit-Haibach ◽

...

Keyword(s):

Pancreatic Cancer ◽

Fdg Pet ◽

Contrast Enhanced ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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The Value of 18F-FDG PET/CT in Diagnosing Pancreatic Lesions: Comparison With CA19-9, Enhanced CT or Enhanced MR

10.21203/rs.3.rs-116182/v1 ◽

2020 ◽

Author(s):

Shengyun Huang ◽

Huanhuan Chong ◽

Xun Sun ◽

Zhijian Wu ◽

Qing Jia ◽

...

Keyword(s):

Pancreatic Cancer ◽

Fdg Pet ◽

Diagnostic Efficiency ◽

Joint Application ◽

Main Challenge ◽

Contrast Enhanced ◽

Incidence And Mortality ◽

Pet Ct ◽

Enhanced Ct ◽

Fdg Pet Ct

Abstract Background: Pancreatic cancer is one of the most fatal tumors in the world, which incidence and mortality have continued to rise in the past decade. The main challenge in clinical practice for patients with pancreatic cancer is to accurately distinguish malignant lesions from benign ones in early evaluation. This research aims to investigate the value of 18F-FDG PET/CT in diagnosing pancreatic lesions, and compare it with CA19-9, contrast-enhanced CT (CECT), and contrast-enhanced MRI (CEMR).Methods: Cases of patients with suspected pancreatic lesions examined between Jan 1st, 2011 and June 30th, 2017 were retrospectively analyzed. CA19-9, CECT and CEMR within 2 weeks of PET/CT were evaluated. We compared the diagnostic efficacy of PET/CT with CA19-9, CECT and CEMR as well as combined tests.Results: A total of 467 cases were examined in this study, including 293 males and 174 females, with an average age of 57.79 ± 12.68 y (16–95 y). Cases in the malignant group (n=248) had significantly higher SUVmax (7.34 ± 4.17 vs. 1.70 ± 2.68, P < 0.001) and CA19-9 (663.21 ± 531.98 vs. 87.80 ± 218.47, P < 0.001) than those in the benign group (n=219). The sensitivity, specificity and accuracy of PET/CT were 91.9%, 96.3% and 94.0% respectively. Those for CECT were 83.6%, 77.8%, 81.2% respectively; and 91.2%, 75.0%, 81.7% were for CEMR. PET/CT corrected 14.7% (28/191) CECT diagnoses and 12.2% (10/82) CEMR diagnoses. Although the diagnostic efficiency of CA19-9 was acceptable (80.0%, 69.0%, 74.9% respectively), the joint application of PET/CT and CA19-9 could significantly enhance the diagnostic efficiency compared with PET/CT alone (sen 97.4% vs. 90.5%, P =0.0003; spe 100.0% vs. 95.2%, P = 0.0047). Conclusions: PET/CT has sensitivity similar to CECT, CEMR and significantly higher specificity and accuracy, helping reduce false diagnoses of morphological images. Combining PET/CT with CA19-9 could enhance diagnostic efficiency.

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Solitary Pulmonary Nodules: Comparison of Dynamic First-Pass Contrast-enhanced Perfusion Area-Detector CT, Dynamic First-Pass Contrast-enhanced MR Imaging, and FDG PET/CT

Radiology ◽

10.1148/radiol.14132289 ◽

2015 ◽

Vol 274 (2) ◽

pp. 563-575 ◽

Cited By ~ 36

Author(s):

Yoshiharu Ohno ◽

Mizuho Nishio ◽

Hisanobu Koyama ◽

Shinichiro Seki ◽

Maho Tsubakimoto ◽

...

Keyword(s):

Mr Imaging ◽

Fdg Pet ◽

Pulmonary Nodules ◽

Solitary Pulmonary Nodules ◽

Area Detector ◽

Contrast Enhanced ◽

Pet Ct ◽

First Pass ◽

Fdg Pet Ct

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Accuracy of 18F-FDG PET/CT, Multidetector CT, and MR Imaging in the Diagnosis of Pancreatic Cysts: A Prospective Single-Center Study

Journal of Nuclear Medicine ◽

10.2967/jnumed.114.148940 ◽

2015 ◽

Vol 56 (8) ◽

pp. 1163-1168 ◽

Cited By ~ 26

Author(s):

S. Kauhanen ◽

I. Rinta-Kiikka ◽

J. Kemppainen ◽

J. Gronroos ◽

S. Kajander ◽

...

Keyword(s):

Mr Imaging ◽

Fdg Pet ◽

Multidetector Ct ◽

Pancreatic Cysts ◽

Single Center ◽

Pet Ct ◽

Single Center Study ◽

18F Fdg ◽

Fdg Pet Ct ◽

Center Study

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18F-FDG PET/CT versus Diagnostic Contrast-Enhanced CT for Follow-Up of Stage IV Melanoma Patients Treated by Immune Checkpoint Inhibitors: Frequency and Management of Discordances over a 3-Year Period in a University Hospital

Diagnostics ◽

10.3390/diagnostics11071198 ◽

2021 ◽

Vol 11 (7) ◽

pp. 1198

Author(s):

Jean-Baptiste Le Goubey ◽

Charline Lasnon ◽

Ines Nakouri ◽

Laure Césaire ◽

Michel de Pontville ◽

...

Keyword(s):

Fdg Pet ◽

Stage Iv ◽

Anatomical Site ◽

Contrast Enhanced Ct ◽

Contrast Enhanced ◽

Pet Ct ◽

Enhanced Ct ◽

18F Fdg ◽

Fdg Pet Ct ◽

Induced Changes

Aim: To perform a comprehensive analysis of discordances between contrast-enhanced CT (ceCT) and 18F-FDG PET/CT in the evaluation of the extra-cerebral treatment monitoring in patients with stage IV melanoma. Materials and methods: We conducted a retrospective monocentric observational study over a 3-year period in patients referred for 18F-FDG PET/CT and ceCT in the framework of therapy monitoring of immune checkpoint (ICIs) as of January 2017. Imaging reports were analyzed by two physicians in consensus. The anatomical site responsible for discordances, as well as induced changes in treatment were noted. Results: Eighty patients were included and 195 pairs of scans analyzed. Overall, discordances occurred in 65 cases (33%). Eighty percent of the discordances (52/65) were due to 18F-FDG PET/CT scans upstaging the patient. Amongst these discordances, 17/52 (33%) led to change in patient’s management, the most frequent being radiotherapy of a progressing site. ceCT represented 13/65 (20%) of discordances and induced changes in patients’ management in 2/13 cases (15%). The most frequent anatomical site involved was subcutaneous for 18F-FDG PET/CT findings and lung or liver for ceCT. Conclusions: Treatment monitoring with 18F-FDG PET/CT is more efficient than ceCT and has a greater impact in patient’s management.

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