Contraction of guinea pig ileal smooth muscle by acetyl glyceryl ether phosphorylcholine
1981 ◽
Vol 241
(3)
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pp. C130-C133
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Keyword(s):
Acetyl glyceryl ether phosphorylcholine (AGEPC) is a chemical that has the biological activity of what was formerly termed platelet-activating factor. We report here that synthetic AGEPC induces the contraction of guinea pig ileal smooth muscle. Antagonists of histamine, acetylcholine, and slow-reacting substances (SRS) do not block AGEPC-induced contraction. These responses were long lasting, resistant to washing, and displayed complete agonist specific desensitization. Histamine- and SRS-induced contractions were unaffected by AGEPC. These studies show that AGEPC has the potential to produce a component of anaphylactically induced smooth muscle contraction.
1989 ◽
Vol 340
(3)
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Keyword(s):
1983 ◽
Vol 80
(4)
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pp. 1120-1124
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1996 ◽
Vol 23
(4)
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pp. 310-316
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1988 ◽
Vol 66
(6)
◽
pp. 820-825
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2010 ◽
Vol 298
(5)
◽
pp. C1118-C1126
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1988 ◽
Vol 65
(2)
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pp. 914-920
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1999 ◽
Vol 372
(3)
◽
pp. 269-277
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Keyword(s):
1993 ◽
Vol 425
(5-6)
◽
pp. 462-468
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Keyword(s):