Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.
1978 ◽
Vol 235
(2)
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pp. E97
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Keyword(s):
Physiological and pharmacological studies of hormones, drugs, and neurotransmitters often generate families of sigmoidal dose-response curves. Optimally efficient data analysis should involve simultaneous description of all curves, rather than fitting each one individually. We have developed a general computerized method to describe the dose-response curves in terms of basal and maximal responses, ED50, and curve shape or steepness. This facile method permits rigorous statistical analysis, provides a basis for pooling of information from separate experiments, and allows one to test which characteristics are shared by various curves.
2005 ◽
Vol 289
(3)
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pp. E363-E365
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Keyword(s):
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2001 ◽
2021 ◽
Vol 21
(1)
◽
pp. 69-110
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Keyword(s):
1983 ◽
Vol 258
(22)
◽
pp. 13849-13856
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Keyword(s):