melatonin suppression
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2022 ◽  
Author(s):  
Lauren E. Hartstein ◽  
Cecilia Diniz Behn ◽  
Lameese D. Akacem ◽  
Nora Stack ◽  
Kenneth P. Wright ◽  
...  

2021 ◽  
Vol 13 (14) ◽  
pp. 2767
Author(s):  
Martin Aubé ◽  
Julien-Pierre Houle ◽  
Justine Desmarais ◽  
Nikki Veilleux ◽  
Émie Bordeleau

This paper describes the use of a new obtrusive light module of the Illumina v2 model to estimate the light that may enter bedroom windows. We used the following as input to the model: (1) the sources’ flux and spectrum derived from the color images taken by astronauts from the International Space Station (ISS), (2) an association between source spectrum and angular emission, and (3) a per zone inventory of obstacles properties and lamp height. The model calculates the spectral irradiance incident to buildings’ windows taking into account the orientation of the street. By using the color information from an ISS image, we can classify pixels as a function of their spectra. With the same image, it is also possible to determine the upward photopic radiance for each pixel. Both serve as inputs to the model to calculate the spectral irradiance on any window. By having the spectral irradiance, it is possible to determine the Melatonin Suppression Index and the photopic irradiance on the window. Such information can later be used to perform epidemiological studies. The new methodology is applied to the city of Montréal in Canada for a set of houses’ locations. The computations are made for 2013 (pre-LED era).


PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0254171
Author(s):  
Raquel Arguelles-Prieto ◽  
Juan Antonio Madrid ◽  
Maria Angeles Rol ◽  
Maria Angeles Bonmati-Carrion

An appropriate exposure to the light-dark cycle, with high irradiances during the day and darkness during the night is essential to keep our physiology on time. However, considering the increasing exposure to artificial light at night and its potential harmful effects on health (i.e. chronodisruption and associated health conditions), it is essential to understand the non-visual effects of light in humans. Melatonin suppression is considered the gold standard for nocturnal light effects, and the activation of intrinsically photosensitive retinal ganglion cells (ipRGCs) through the assessment of pupillary light reflex (PLR) has been recently gaining attention. Also, some theoretical models for melatonin suppression and retinal photoreceptors activation have been proposed. Our aim in this study was to determine the influence of correlated color temperature (CCT) on melatonin suppression and PLR, considering two commercial light sources, as well as to explore the possible correlation between both processes. Also, the contribution of irradiance (associated to CCT) was explored through mathematical modelling on a wider range of light sources. For that, melatonin suppression and PLR were experimentally assessed on 16 healthy and young volunteers under two light conditions (warmer, CCT 3000 K; and cooler, CCT 5700 K, at ~5·1018 photons/cm2/sec). Our experimental results yielded greater post-stimulus constriction under the cooler (5700 K, 13.3 ± 1.9%) than under the warmer light (3000 K, 8.7 ± 1.2%) (p < 0.01), although no significant differences were found between both conditions in terms of melatonin suppression. Interestingly, we failed to demonstrate correlation between PLR and melatonin suppression. Although methodological limitations cannot be discarded, this could be due to the existence of different subpopulations of Type 1 ipRGCs differentially contributing to PLR and melatonin suppression, which opens the way for further research on ipRGCs projection in humans. The application of theoretical modelling suggested that CCT should not be considered separately from irradiance when designing nocturnal/diurnal illumination systems. Further experimental studies on wider ranges of CCTs and light intensities are needed to confirm these conclusions.


Author(s):  
Martin Aubé ◽  
Julien-Pierre Houle ◽  
Justine Desmarais ◽  
Nikki Veilleux ◽  
Émie Bordeleau

This paper describes the use of a new obtrusive light module of the Illumina v2 model to estimate the light that may enter bedroom windows. We used as input to the model, 1- the sources&rsquo; flux and spectrum derived from the color images taken by astronauts from the international space station, 2- an association between source spectrum and angular emission, and 3- a per zone inventory of obstacles properties and lamp height. The model calculate the spectral irradiance incident to buildings&rsquo; windows taking into account for the orientation of the street. By using the color information from an ISS image, we can classify pixels as a function of their spectra. With the same image, it is also possible to determine the upward photopic radiance for each pixel. Both serve as inputs to the model to calculate the spectral irradiance on any window. By having the spectral irradiance, it is possible to determine the Melatonin Suppression Index and the photopic irradiance on the window. Such information can later be used to perform epidemiological studies. The new methodology is applied to the case of Montr&eacute;al in Canada for a set of houses&rsquo; locations. The computations are made for 2013 (pre-LED era).


2021 ◽  
Vol 3 (1) ◽  
pp. 181-188
Author(s):  
Peter Bracke ◽  
Eowyn Van de Putte ◽  
Wouter R. Ryckaert

Dose-response curves for circadian phase shift and melatonin suppression in relation to white or monochromatic nighttime illumination can be scaled to melanopic weighed illumination for normally constricted pupils, which makes them easier to interpret and compare. This is helpful for a practical applications.


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