An indisputable role of NHE8 in mucosal protection
2020 ◽
Vol 319
(4)
◽
pp. G421-G431
Keyword(s):
Loss of Na+/H+ exchanger isoform 8 (NHE8), a Slc9 family of exchanger that contributes to sodium uptake, cell volume regulation, and intracellular pH homeostasis, resulted in dysbiosis with reduction of butyrate-producing bacteria and decrease of Muc2 production in the intestine in mice. Introducing fecal microbiota transplantation (FMT) and VSL#3 in NHE8 knockout (NHE8KO) mice failed to rebalance the microbiota in these mice. Furthermore, administration of FMT, VSL#3, and sodium butyrate was unable to restore mucin production in the absence of NHE8 in the intestine.
1998 ◽
Vol 275
(4)
◽
pp. C1067-C1080
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Keyword(s):
1997 ◽
Vol 273
(2)
◽
pp. C360-C370
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2003 ◽
Vol 122
(2)
◽
pp. 177-190
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2000 ◽
Vol 523
(1)
◽
pp. 147-154
◽
Keyword(s):
1993 ◽
Vol 264
(5)
◽
pp. C1316-C1326
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1989 ◽
Vol 171
(8)
◽
pp. 4410-4416
◽
2001 ◽
Vol 11
(6)
◽
pp. 285-294
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Keyword(s):