Pancreatic blood flow in the rat during enlargement, involution, and cholecystokinin treatment

1984 ◽  
Vol 247 (5) ◽  
pp. G457-G462 ◽  
Author(s):  
P. S. Oates ◽  
N. W. Bruce ◽  
R. G. Morgan
Keyword(s):  
Blood Flow ◽  
Response To Treatment ◽  
Soya Flour ◽  
Pancreatic Blood Flow ◽  
Pancreatic Growth ◽  
Trophic Hormone

We studied the effect of raw soya flour (RSF) given as a single gavage or for long-term periods on pancreatic blood flow. These effects were compared with the response to treatment with cholecystokinin (CCK) since it has been suggested that RSF feeding releases CCK. In acute experiments total pancreatic blood flow was significantly increased after infusion of CCK (60 Ivy dog units X kg-1 X h-1) and after gavage with preparations of RSF or heated soya flour (HSF). When expressed as flow per 100 g pancreatic weight, the greatest increase was seen after gavage with RSF. In separate chronic studies, total pancreatic blood flow was significantly increased in rats fed RSF for 4 wk compared with rats fed HSF, but because of pancreatic enlargement in rats fed RSF flow per 100 g pancreatic weight was similar in the two groups. When rats fed RSF for 4 wk were changed to standard rat cubes for 48 h before study, pancreatic blood flow (ml/min and ml X min-1 X 100 g pancreas-1) and total pancreatic DNA decreased significantly compared with rats fed RSF continuously. However, when CCK was infused intravenously during the 48-h period on cubes, pancreatic blood flow and DNA remained significantly increased and were not significantly different from values in rats fed RSF continuously. These results show that the effects of RSF feeding and CCK treatment on pancreatic growth and blood flow are similar and are consistent with the postulated role of CCK as the trophic hormone released by RSF feeding.

Erection Capability Is Potentiated by Long-Term Sildenafil Treatment: Role of Blood Flow-Induced Endothelial Nitric-Oxide Synthase Phosphorylation

2005 ◽  
Vol 68 (1) ◽  
pp. 226-232 ◽  
Author(s):  
Biljana Musicki ◽  
Hunter C. Champion ◽  
Robyn E. Becker ◽  
Tongyun Liu ◽  
Melissa F. Kramer ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

High dietary salt reduces the contribution of 20-HETE to arteriolar oxygen responsiveness in skeletal muscle

2007 ◽  
Vol 292 (3) ◽  
pp. H1507-H1515 ◽  
Author(s):  
Paul J. Marvar ◽  
John R. Falck ◽  
Matthew A. Boegehold
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
High Salt ◽  
Tissue Blood Flow ◽  
Dietary Salt ◽  
Metabolic Demand ◽  
Long Term Effect ◽  
Arteriolar Tone

The coupling of tissue blood flow to cellular metabolic demand involves oxygen-dependent adjustments in arteriolar tone, and arteriolar responses to oxygen can be mediated, in part, by changes in local production of 20-HETE. In this study, we examined the long-term effect of dietary salt on arteriolar oxygen responsiveness in the exteriorized, superfused rat spinotrapezius muscle and the role of 20-HETE in this responsiveness. Rats were fed either a normal-salt (NS, 0.45%) or high-salt (HS, 4%) diet for 4–5 wk. There was no difference in steady-state tissue Po2 between NS and HS rats, and elevation of superfusate oxygen content from 0% to 10% caused tissue Po2 to increase by the same amount in both groups. However, the resulting reductions in arteriolar diameter and blood flow were less in HS rats than NS rats. Inhibition of 20-HETE formation with N-methylsulfonyl-12,12-dibromododec-11-enamide (DDMS) or 17-octadecynoic acid (17-ODYA) attenuated oxygen-induced constriction in NS rats but not HS rats. Exogenous 20-HETE elicited arteriolar constriction that was greatly reduced by the large-conductance Ca2+-activated potassium (KCa) channel inhibitors tetraethylammonium chloride (TEA) and iberiotoxin (IbTx) in NS rats and a smaller constriction that was less sensitive to TEA or IbTx in HS rats. Arteriolar responses to exogenous angiotensin II were similar in both groups but more sensitive to inhibition with DDMS in NS rats. Norepinephrine-induced arteriolar constriction was similar and insensitive to DDMS in both groups. We conclude that 20-HETE contributes to oxygen-induced constriction of skeletal muscle arterioles via inhibition of KCa channels and that a high-salt diet impairs arteriolar responses to increased oxygen availability due to a reduction in vascular smooth muscle responsiveness to 20-HETE.

Role of Pancreatic Blood Flow and Vasoactive Substances in the Development of Canine Acute Pancreatitis

1993 ◽  
Vol 55 (5) ◽  
pp. 531-536 ◽  
Author(s):  
F. Yotsumoto ◽  
T. Manabe ◽  
G. Ohshio ◽  
K. Imanishi ◽  
K. Ando ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Blood Flow ◽  
Pancreatic Blood Flow ◽  
Vasoactive Substances

Role of nitric oxide in the relationship of pancreatic blood flow and exocrine secretion in cats

1995 ◽  
Vol 108 (4) ◽  
pp. 1215-1220 ◽  
Author(s):  
Ameet G. Patel ◽  
Mark T. Toyama ◽  
Thanh N. Nguyen ◽  
Gordon A. Cohen ◽  
Louis J. Ignarro ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Exocrine Secretion ◽  
Pancreatic Blood Flow ◽  
Relationship Of ◽  
The Relationship

Role of cholecystokinin in the intestinal phase of pancreatic circulation in dogs

2001 ◽  
Vol 280 (4) ◽  
pp. G614-G620 ◽  
Author(s):  
Morio Nakajima ◽  
Satoru Naruse ◽  
Motoji Kitagawa ◽  
Hiroshi Ishiguro ◽  
Chunxiang Jin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Protein Secretion ◽  
Systemic Blood Pressure ◽  
Intestinal Blood Flow ◽  
Pancreatic Blood Flow ◽  
Intraduodenal Infusion ◽  
Blood Flows ◽  
Intestinal Phase

The regulatory mechanisms of postprandial pancreatic hyperemia are not well characterized. The aim of this study is to clarify the role of cholecystokinin (CCK) in the intestinal phase of pancreatic circulation. Pancreatic, gastric, and intestinal blood flows were measured by ultrasound transit-time blood flowmeters in five conscious dogs. Pancreatic and gastric secretion and blood pressure were also monitored. Synthetic CCK octapeptide (CCK-8) or gastrin heptadecapeptide (gastrin-17) was infused intravenously, and milk was infused into the duodenum with or without loxiglumide, a specific CCK-A receptor antagonist. CCK-8 induced dose-related increases of pancreatic, but not gastric or intestinal, blood flow and protein secretion without affecting systemic blood pressure. Gastrin-17 did not affect pancreatic blood flow. An intraduodenal infusion of milk increased pancreatic and intestinal blood flows and pancreatic protein secretion. Loxiglumide completely inhibited pancreatic blood flow and protein responses to CCK-8 and milk but not the intestinal blood flow response. CCK is a potent and specific pancreatic vasodilator, with its effect mediated by CCK-A receptors. CCK plays an important role in the regulation of the intestinal phase of the pancreatic circulation in dogs.

scholarly journals The Role of Doppler Ultrasound in the Diagnosis of Postnatal Testicular Torsion in Children

2021 ◽  
pp. 69-81
Author(s):  
E. B. Olkhova ◽  
S. Yu. Borisov ◽  
M. V. Topolnik ◽  
A. Yu. Tagirova ◽  
S. V. Zhumasitov ◽  
...  
Keyword(s):  
Blood Flow ◽  
Prognostic Value ◽  
Testicular Torsion ◽  
Neonatal Period ◽  
Color Doppler ◽  
Diagnostic Significance ◽  
Doppler Study ◽  
Testicular Blood Flow

The diagnostic significance of the color Doppler study of testicular blood flow in testicular torsion has been studied for about 40 years, however, the prognostic value of the results obtained is ambiguous, as are the actual imaging capabilities of the technique. Our own experience of 110 observations of testicular torsion in children older than the neonatal period allows us to draw statistically reliable conclusions. Made on equipment premium-class research made it possible to evaluate how visualization intratesticular vascular pattern, and whirpool-sign and submit the primitive model of the actual inversion, explaining the impossibility of rendering whirpool-sign with the greatest tight inversion. The dynamics of testicular blood flow was studied immediately after successful and unsuccessful manual detorsion and in the long term after operative detorsion and orchopexy. The publication contains a brief analysis of the literature and is extensively illustrated.

Role of Local Pancreatic Blood Flow in Development of Hemorrhagic Pancreatitis Induced by Stress in Rats

Pancreas ◽  
1993 ◽  
Vol 8 (4) ◽  
pp. 499-505 ◽  
Author(s):  
Masayuki Fumkawa ◽  
Toshinari Kimura ◽  
Toshihiko Sumii ◽  
Hiroya Yamaguchi ◽  
Hajime Nawata
Keyword(s):  
Blood Flow ◽  
Pancreatic Blood Flow ◽  
Hemorrhagic Pancreatitis
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