scholarly journals Left ventricular dyssynchrony and post-systolic shortening in young bodybuilders using anabolic-androgenic steroids

2021 ◽  
Author(s):  
Antoine Grandperrin ◽  
Iris Schuster ◽  
Thomas Rupp ◽  
Omar IZEM ◽  
Philippe Obert ◽  
...  
Keyword(s):  
Left Ventricular ◽  
Left Ventricular Dyssynchrony ◽  
Anabolic Androgenic Steroids ◽  
Lv Function ◽  
Ventricular Dyssynchrony ◽  
Lv Dyssynchrony ◽  
2D Strain ◽  
Lv Remodeling ◽  
Androgenic Steroids ◽  
Longitudinal Strains

Background: Left ventricular (LV) remodeling, characterized by increased LV hypertrophy and depressed function, is observed in strength-trained athletes who use anabolic-androgenic steroids (AAS). Previous studies reported an increase in cardiac fibrosis in these athletes, which could promote intraventricular dyssynchrony. In this context, this study evaluated LV dyssynchrony in strength-trained athletes using AA; hypothesizing that the use of AAS leads to an increase in LV dyssynchrony with an increase in post-systolic shortening. Methods: Forty-four participants (aged 20-40 years) were divided into three age-matched groups: strength-trained athletes using AAS (users, n=14) and those who were not (non-users, n=15), and healthy sedentary men (controls, n=15),. After completing a survey, each participant was assessed with 2D-strain echocardiography. Left ventricular dyssynchrony was quantified using the standard deviation of the time to peak for longitudinal strains (SD), the longitudinal strain delay index (LSDI) and the segmental post-systolic index (PSI). Results: Users exhibited a greater LV mass index and higher systolic and diastolic functions than both controls and non-users. The decrease in LV strains in users was predominantly observed at the interventricular segments. The SD, LSDI and PSI, calculated on the basal inferoseptal, basal anteroseptal and basal inferolateral segments, were higher in users. Conclusion: The results strongly support that the specific LV remodeling observed in young AAS users was associated with an increase in LV dyssynchrony. The correlations with ejection fraction suggested that wasted energy, due to post-systolic shortenings, contributed in part to the decrease in LV function in strength-trained athletes using AAS.

scholarly journals Left Ventricular Dyssynchrony in Acute ST Elevated Myocardial Infarction in Patients with Normal QRS duration

2016 ◽  
Vol 30 (1) ◽  
pp. 13-21
Author(s):  
Iftekhar Alam ◽  
Tuhin Haque ◽  
Mohammad Badiuzzaman ◽  
Abdullah Al Masud ◽  
Abrar Kaiser ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Peak Systolic Velocity ◽  
Left Ventricular ◽  
Left Ventricular Dyssynchrony ◽  
Control Group ◽  
Ventricular Dyssynchrony ◽  
Acute Stemi ◽  
Lv Dyssynchrony ◽  
Qrs Duration ◽  
Ejection Phase

Background: The aim of this study was to assess left ventricular dyssynchrony after acute ST elevated myocardial infarction (STEMI) in patients with normal QRS duration. Real time 3D echocardiography (RT3DE) with triplane tissue synchronization imaging (TSI) used to identify segmental left ventricular systolic velocity in ejection phase to evaluate LV dyssynchrony in patients with STEMI and the findings were compared with control.Materials and methods: RT3DE with triplane TSI was performed within 4 days of AMI after thrombolysis or primary PCI in 31 patients and compared with 31 agematched controls. Regional myocardial velocities were assessed in 12 segments in ejection phase, and the corresponding time to peak systolic velocity (Ts) was measured. To assess LV dyssynchrony Ts-4, Ts-6, Ts- SD-6, Ts-12 and Ts-SD-12 were computed by offline dedicated software semi-automatically.Results: The dyssynchrony parameters were significantly prolonged in patients with AMI. Among the dyssynchrony parameters TS-SD-12 was better indicator of LV dyssynchrony. The Ts-SD-12 was significantly prolonged in the STEMI group when compared with controls. In patients with acute STEMI mean Ts-SD-12 was 43.2±19.1 milliseconds whereas in control group it was 23.0 ±6.5 milliseconds (p<0.05). The Ts-SD-12 was prolonged in patients with Anterior than Inferior STEMI as follows respectively 45.9± 17.6 and 40.0± 21 milliseconds.Conclusions: Triplane TSI by RT3DE is useful in evaluating LV dyssynchrony in patients with acute STEMI and even in those with normal QRS duration there is significant left ventricular dyssynchrony early after STEMI.Bangladesh Heart Journal 2015; 30(1) : 13-21

Abstract 3069: Reduction of Left Ventricular Dyssynchrony after Catheter Ablation for Isolated Permanent Atrial Fibrillation in Patients with Depressed Left Ventricular Function

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Patricia Reant ◽  
Stephane Lafitte ◽  
Frederic Sacher ◽  
Nicolas Derval ◽  
Stephanie Brette ◽  
...  
Keyword(s):  
Catheter Ablation ◽  
Ejection Fraction ◽  
Left Ventricular ◽  
Lv Function ◽  
Ventricular Dyssynchrony ◽  
Permanent Atrial Fibrillation ◽  
Lv Dyssynchrony ◽  
Lv Ejection Fraction ◽  
Group 2 ◽  
Group 1

Background: Persistent/Permanent atrial fibrillation (Per AF) and electromechanical left ventricular (LV) dyssynchrony are frequently associated in patients with systolic heart failure. Their relationships have not been investigated yet. Objective: We hypothesized that Per AF could induce or worsen ventricular dyssynchrony. The aim of this prospective study was to evaluate the degree of LV dyssynchrony in patients with Per AF and depressed LV function; to describe the evolution of dyssynchrony after AF catheter ablation. Methods: 28 patients with isolated Per AF and depressed LV function were investigated with a VIVID7 (General Electric) before ablation (D-1), at 1 month (M+1) and at 6 month (M+6) after the procedure and compared to 28 controls. LV ejection fraction was evaluated by biplane Simpson rule. LV dyssynchrony was quantified by tissue Doppler imaging in apical views using a triplane 3D/4D acquisition. Maximal difference between times to peak (mdTP) was determined. TP was measured as the delays between the onset of the QRS and the peak velocity of systolic wave on the 6 basal LV segments. Values were averaged on 3 consecutive cardiac cycles. LV dyssynchrony was defined for a mdTP value >65ms. Parameters of dyssynchrony were normalized to RR interval. Results: Before ablation, mdTP was >65ms for 10 (36%) of the patients (group1) and >65ms for 18 patients (group 2). Ejection fraction was significantly lower in group 1 than in group 2. During the follow-up, the LV ejection fraction increase was similar in the 2 groups (+42%; +41%)(Table ). In the whole population, mdTP decreased from 57.5±35ms to 44.1±35ms (P<0.05). However, the LV dyssynchrony improvement was much more marked in group 1 than in group 2 (−42%; −13%). Conclusions: In this study, LV dyssynchrony was present in 36% of the patients with permanent AF and impaired LV ejection fraction. Catheter ablation significantly improved both LV ejection fraction and LV dyssynchrony in this population. Table

A New Method to Diagnose Left Ventricular Dyssynchrony With Analysis of Heart Wall Thickening From Cardiac CT

2008 ◽  
Author(s):  
Matthew J. Goette ◽  
Jana G. Delfino ◽  
Brandon K. Fornwalt ◽  
John N. Oshinski
Keyword(s):  
Heart Failure ◽  
Pathological Condition ◽  
Left Ventricular ◽  
Cardiac Resynchronization ◽  
Left Ventricular Dyssynchrony ◽  
Wall Thickening ◽  
Ventricular Dyssynchrony ◽  
Refractory Heart Failure ◽  
Myocardial Wall ◽  
Lv Dyssynchrony

Left ventricular (LV) dyssynchrony is a pathological condition in which segments of the myocardial wall contract at different times. This dyssynchrony results in a decreased LV ejection fraction (EF) and an increased level of mitral regurgitation. LV dyssynchrony has been linked to higher rates of morbidity, mortality, and arrhythmic susceptibility in patients with congestive heart failure. Cardiac resynchronization therapy (CRT) with biventricular pacemakers has benefited patients with drug-refractory heart failure and signs of ventricular dyssynchrony. Patients are currently selected for CRT therapy if they have a prolonged QRS complex (> 120 msec) on a surface electrocardiogram as well as an EF of less than 35%. However, recent data suggests that these criteria are insufficient, as 30% of patients do not respond to CRT treatments.

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