Question of an Inhibitory Hormone From the Gastric Antrum

1957 ◽  
Vol 191 (1) ◽  
pp. 64-70 ◽  
Author(s):  
Enrique H. Longhi ◽  
Herbert B. Greenlee ◽  
Jose L. Bravo ◽  
Jose Delgadillo Guerrero ◽  
Lester R. Dragstedt
Keyword(s):  
Gastric Secretion ◽  
Parietal Cells ◽  
Gastric Antrum ◽  
Heidenhain Pouch

Acid applied to the antrum mucosa in dogs inhibits the gastric phase of gastric secretion as exhibited in the vagus denervated Heidenhain pouch. To determine if this inhibition of secretion is due to failure of formation or release of gastrin from the antrum, or to the liberation of an inhibitory hormone from the gastric antrum which acts on the parietal cells, dogs were prepared with an isolated Heidenhain pouch and two pouches prepared from the gastric antrum. These antrum pouches were prepared with vagus innervation intact and with vagus innervation eliminated. Gastric secretion in the Heidenhain pouch elicited by the introduction of liver solution or acetylcholine into one of the antrum pouches was not inhibited by the introduction of acid into the second antrum pouch. These data suggest that acid in contact with the antrum mucosa prevents the formation or release of gastrin and does not release an inhibitory hormone.

The Role of the Gastric Antrum in the Regulation of Gastric Secretion

1960 ◽  
Vol 38 (1) ◽  
pp. 7-14 ◽  
Author(s):  
E.R. Woodward
Keyword(s):  
Gastric Secretion ◽  
Gastric Antrum

Effects of bombesin on food intake and gastric acid secretion in cats

1989 ◽  
Vol 256 (1) ◽  
pp. R181-R186
Author(s):  
A. Bado ◽  
M. J. Lewin ◽  
M. Dubrasquet
Keyword(s):  
Gastric Emptying ◽  
Food Intake ◽  
Gastric Secretion ◽  
Acid Secretion ◽  
Gastric Fistula ◽  
Single Class ◽  
Heidenhain Pouch ◽  
Daily Food Intake ◽  
Feeding Experiments ◽  
Daily Food

The brain and gut peptide bombesin has been reported both to stimulate gastric secretion and to induce satiety. To understand how the peripheral administration of bombesin affects food intake and whether gastric mechanisms are involved, a comparative study of the doses of bombesin active on gastric secretion, gastric emptying, and food intake was undertaken in cats provided with a gastric fistula and a denervated Heidenhain pouch. The smallest dose of intravenous bombesin that stimulated significantly basal acid secretion (20 pmol.kg-1.h-1) by the gastric fistula also enhanced meal-stimulated acid secretion by the Heidenhain pouch (+138%, P less than 0.01), delayed gastric emptying of a liquid protein meal (-30%, P less than 0.01), and suppressed food intake when the test meal was allowed to reach the stomach (-15%, P less than 0.01). Conversely, in sham-feeding experiments, the same dose of bombesin increased food intake (+35%, P less than 0.01). In full-day experiments conducted in nonfasted cats, bombesin decreased both the food intake in the 4-h period after the infusion and the daily food intake, whereas octapeptide cholecystokinin induced a transient satiety but did not decrease daily food intake. These results indicate that in cats the interaction of bombesin with "pregastric" mechanisms is not sufficient to induce satiety and that a relation could exist between the effects of bombesin on gastric secretion, emptying, and food intake. A single class of receptors might be involved in these peripheral effects of bombesin.

Stimulating Effect of Vagotomy on Gastric Secretion in Heidenhain Pouch Dog

1953 ◽  
Vol 174 (2) ◽  
pp. 219-225 ◽  
Author(s):  
Shirl O. Evans ◽  
Jose M. Zubiran ◽  
Jack D. McCarthy ◽  
Herzl Ragins ◽  
Edward R. Woodward ◽  
...  
Keyword(s):  
Gastric Secretion ◽  
Heidenhain Pouch

Effects of Calcium Infusion on Gastric Secretion in Heidenhain Pouch Dogs

1966 ◽  
Vol 1 (2) ◽  
pp. 124-131 ◽  
Author(s):  
M. Mignon ◽  
J.-M. Limbosch ◽  
J. H. Wyllie ◽  
M. J. Rheault ◽  
L. M. Nyhus
Keyword(s):  
Gastric Secretion ◽  
Heidenhain Pouch ◽  
Calcium Infusion

Inhibition of gastric secretion by thyroid preparations

1959 ◽  
Vol 196 (6) ◽  
pp. 1262-1265 ◽  
Author(s):  
E. S. Nasset ◽  
V. W. Logan ◽  
M. L. Kelley ◽  
Mary Thomas
Keyword(s):  
Gastric Secretion ◽  
Gastric Juice ◽  
Gradual Decline ◽  
Heidenhain Pouch ◽  
Significant Fall ◽  
Lean Beef ◽  
Inhibition Of Gastric Secretion

Four dogs with Thomas gastric pouches and one dog with a Heidenhain pouch were stimulated to secrete gastric juice by feeding 100 gm of lean beef. Feeding whole desiccated thyroid ordinarily caused a significant fall in volume of gastric juice and in the total quantity of HCl secreted. Crystalline thyroxine yielded erratic results and one trial with triiodothyronine produced a significant increase in gastric secretion. Thyroidectomy in one dog resulted in a gradual decline in secretion, but hypothyroidism produced by administration of mercaptoimidazole in another animal lead to a significant increase in secretion.

THE EFFECT OF ANOXIA ON GASTRIC SECRETION FROM PAVLOV AND HEIDENHAIN POUCH DOGS

1939 ◽  
Vol 127 (4) ◽  
pp. 637-641 ◽  
Author(s):  
Arthur D. Pickett ◽  
Edward J. Van Liere
Keyword(s):  
Gastric Secretion ◽  
Heidenhain Pouch

Secretin effect on gastrin, gastric secretion in dogs with chronic antral stimulation

1975 ◽  
Vol 228 (6) ◽  
pp. 1775-1781 ◽  
Author(s):  
S Nasca ◽  
M Mignon ◽  
L Gramatica ◽  
J-P Accary ◽  
S Bonfils
Keyword(s):  
Gastric Secretion ◽  
Acid Output ◽  
Physiological Activity ◽  
Fold Increase ◽  
Acid Inhibition ◽  
Plasma Gastrin ◽  
Heidenhain Pouch ◽  
Fasting Plasma

Antrocolic transposition in four dogs with Heidenhain pouch and gastrojejunostomyresulted in a marked increase in fasting plasma gastrin concentration and sustained highacid secretion, closely related to gastrin levels. A marked production of pepsin output could not be correlated with plasma gastrin. Reduction in plasma gastrin concentration was more than twofold less pronounced than the reduction in acid output for 1 and 2 U/kg-h, while the 0.5 U/kg-h no effect was noted. For both acid output and gastrin concentrations, close correlations were noted between presecretion level and remaining level upon secretin infusion. Despite the reduction in the secretory volume of the pouch, 0.5 and 1 U/kg-h of secretin induced a 1.5- and 2-fold increase in pepsin output, respectively. Two untis per kilagram-hour decreased the secretory volume as well as the pepsin output. If the physiological release of secretin in dogs does not exceed the equivalent of the lowest dose studied, our results would indicate that acid inhibition is a physiological activity of secretin, while the effect on circulating gastrin concentration seems to be phamacological.

The inhibition of gastric secretion by the duodenum and by the gastric antrum

1962 ◽  
Vol 2 (3) ◽  
pp. 181-196 ◽  
Author(s):  
James C. Thompson
Keyword(s):  
Gastric Secretion ◽  
Gastric Antrum ◽  
Inhibition Of Gastric Secretion
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