Potassium efflux from isolated rabbit heart into a potassium-free solution

1961 ◽  
Vol 200 (1) ◽  
pp. 133-134
Author(s):  
E. W. Humphrey
Keyword(s):  
Potassium Concentration ◽  
Calcium Content ◽  
Rabbit Heart ◽  
Free Solution ◽  
Potassium Efflux ◽  
Isolated Rabbit Heart ◽  
Perfused Rabbit Heart ◽  
Zero Time

The efflux of potassium from the isolated perfused rabbit heart into a potassium-free solution has been calculated from the zero time slope of the washout curve and the initial potassium concentration. It was found that this efflux very closely approximated that calculated from the K42 equilibration curves. Increasing the calcium content of the perfusate twofold had no significant effect on the outflux of potassium.

Potassium flux in the isolated perfused rabbit heart

1960 ◽  
Vol 198 (6) ◽  
pp. 1217-1222 ◽  
Author(s):  
E. W. Humphrey ◽  
J. A. Johnson
Keyword(s):  
Activation Energy ◽  
Potassium Concentration ◽  
Relative Size ◽  
Rabbit Heart ◽  
Extracellular Potassium ◽  
Perfused Rabbit Heart ◽  
Potassium Flux ◽  
Exchange Kinetics ◽  
Kinetics Of ◽  
Total Potassium

The exchange kinetics of potassium in the isolated, perfused rabbit heart have been studied in relation to changes in heart rate, extracellular potassium and temperature. The intracellular potassium appeared to exist in at least two compartments, the relative size varying with the extracellular concentration of potassium. The change in the potassium flux between heart rates of 100 and 200 beats/min. was compared to a change in flux calculated on the basis of the theory proposed by Hodgkin and co-workers and electrical constants taken from the literature. The change in flux estimated from the experimental curves was somewhat smaller than that required by theory and a discussion of this result is given. The activation energy calculated for the total potassium flux into and from the cells was estimated to be from 3000 to 8000 cal/ mole and found to be a function of the potassium concentration in the perfusate.

scholarly journals An Estimate of Reflection Coefficients for Rabbit Heart Capillaries

1964 ◽  
Vol 47 (4) ◽  
pp. 667-677 ◽  
Author(s):  
Fernando Vargas ◽  
John A. Johnson
Keyword(s):  
Weight Change ◽  
Rabbit Heart ◽  
Ringer Solution ◽  
Reflection Coefficients ◽  
Test Substance ◽  
Time Rate ◽  
Loss Of Weight ◽  
Test Molecule ◽  
Zero Time ◽  
Heart Capillaries

Isolated perfused rabbit hearts have been used to determine the reflection coefficients, σ, of the heart capillaries to certain lipoid-insoluble substances. This was done by initially perfusing the heart with a Ringer solution containing no test molecule and then suddenly switching to a solution which differed from the original only by containing a small amount of test substance. This produced a loss of weight of the heart which was continuously recorded as a function of time. Taking the "zero" time rate of weight change and using an equation given by Kedem and Katchalsky reflection coefficients for urea, sucrose, raffinose, and inulin were obtained. These turned out to be 0.1, 0.3, 0.38, and 0.69 respectively. Using the approach of Durbin and Solomon equivalent pore radii were estimated to be about 35 Angstroms.

EFFECTS OF HYPEROXEMIA ON MYOCARDIAL BLOOD FLOW AND OXYGEN CONSUMPTION IN AN ISOLATED RABBIT HEART

1988 ◽  
Vol 69 (3A) ◽  
pp. A216-A216 ◽  
Author(s):  
J. F. Baron ◽  
E. Vicaut ◽  
X. HOU ◽  
P. Vlars ◽  
M. Duvelleroy
Keyword(s):  
Blood Flow ◽  
Oxygen Consumption ◽  
Myocardial Blood Flow ◽  
Rabbit Heart ◽  
Isolated Rabbit Heart

The dual action of suxamethonium on the isolated rabbit heart

Anaesthesia ◽  
1972 ◽  
Vol 27 (2) ◽  
pp. 149-153 ◽  
Author(s):  
Valerie A. Goat ◽  
S. A. Feldman
Keyword(s):  
Rabbit Heart ◽  
Isolated Rabbit Heart ◽  
Dual Action

High-resolution1H NMR imaging of regional ischemia in the isolated perfused rabbit heart at 4.7 T

1991 ◽  
Vol 21 (1) ◽  
pp. 144-150 ◽  
Author(s):  
John C. Chatham ◽  
Stacey Ackerman ◽  
Stephen J. Blackband
Keyword(s):  
Rabbit Heart ◽  
Nmr Imaging ◽  
Regional Ischemia ◽  
Perfused Rabbit Heart
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