Blood flow from and oxygen uptake by muscle, during and after partial venous occlusion

1962 ◽  
Vol 203 (3) ◽  
pp. 470-474 ◽  
Author(s):  
John T. Fales ◽  
S. Richard Heisey ◽  
Kenneth L. Zierler
Keyword(s):  
Blood Flow ◽  
Oxygen Consumption ◽  
Arterial Occlusion ◽  
Venous Occlusion ◽  
Oxygen Debt ◽  
Muscle Oxygen ◽  
Muscle Oxygen Consumption ◽  
Passive Stretch ◽  
Oxygen Difference

In dog gastrocnemius-plantaris muscle in situ, effects of partial venous occlusion and its release were compared to effects of arterial occlusion and release. During partial venous occlusion, blood flow decreases, arteriovenous oxygen difference is constant, and oxygen consumption is, therefore, reduced proportionately to blood flow. On release of partial venous occlusion, unlike release of arterial occlusion in which both blood flow debt and oxygen debt are repaid, there is little or no repayment of blood flow debt, arteriovenous oxygen difference remains constant, and there is, therefore, little or no repayment of oxygen debt. These effects of partial venous occlusion are reminiscent of those reported to occur during and after release of passive stretch of circulated muscle, and it is proposed that the stretch effect is secondary to venular occlusion. The observations are consistent with the hypothesis that, within limits, muscle oxygen consumption is dependent on or limited by blood flow.

Fatigue Increases in Resting Muscle Oxygen Consumption after a Women’s Soccer Match

2020 ◽  
Author(s):  
Aldo Alfonso Vasquez Bonilla ◽  
Rafael Timon ◽  
Alba Camacho-Cardeñosa ◽  
Marta Camacho-cardeñosa ◽  
Samantha Guerrero ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Muscle Pain ◽  
Perceived Exertion ◽  
Arterial Occlusion ◽  
Muscle Oxygenation ◽  
Soccer Match ◽  
Muscle Oxygen ◽  
Muscle Oxygen Consumption ◽  
Resting Muscle ◽  
Women's Soccer

AbstractCurrently, near infrared spectroscopy has a clear potential to explain the mechanisms of fatigue by assessing muscle oxygenation. The objective of the study was to observe the changes in muscle oxygen consumption after an official women’s soccer match. The sample was 14 players who competing in the second division of Spain of women’s soccer. They were evaluated before, immediately after and 24 h after the official match. Biochemical parameters were measured in blood plasma (BUN, GOT, LDH, CPK). The jumping in countermovement, perceived exertion and perceived muscle pain were also assessed. The muscle oxygen consumption and muscle oxygen saturation were evaluated in the gastrocnemius muscle with an arterial occlusion test. ANOVA of repeated measures, Pearson’s correlation and Hopkins’ statistics were applied to measure the magnitudes of change and effect size. There was observed an increase in kinetics of SmO2 at 24 h after the official match, using arterial occlusion. In addition, it was found that the increase in muscle oxygenation correlated with fatigue indicators, such as the increases in LDH, perceived muscle pain and the decrease in countermovement. It is confirmed that a women’s soccer match produced an increase of resting muscle oxygenation in 24 h after the official match.

alpha-Stimulation protects exercise increment in skeletal muscle oxygen consumption

1980 ◽  
Vol 238 (3) ◽  
pp. H331-H339 ◽  
Author(s):  
S. H. Nellis ◽  
S. F. Flaim ◽  
K. M. McCauley ◽  
R. Zelis
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Oxygen Consumption ◽  
Adrenergic Receptor ◽  
Analysis Of Covariance ◽  
Beta Blockade ◽  
Active Muscle ◽  
Muscle Oxygen ◽  
Muscle Oxygen Consumption ◽  
Exercise Induced

Oxygen consumption (VO2) in an isolated, autoperfused, statically exercising canine gracilis muscle (2.5% P0) was studied in low blood flow (Q) states induced by constant norepinephrine (NE) infusion and by mechanical occlusion (MO). Q and VO2 were evaluated at rest (Qc and VO2c), after 5 min of exercise (Qe and VO2e) and after 5 more min of exercise with either NE or MO (Qt and VO2t). Data were normalized and plotted as the VO2e-VO2t)/(VO2c-VO2e) vs. (Qe-Qt)/(Qc-Qe) and equations of the lines for NE (y = 0.090x + 0.048) and for MO (y = 0.488x + 0.070) were determined. The slopes of the lines, tested by analysis of covariance, were significantly different (P less than 0.005). These data indicate that when NE reduced Q during exercise, the exercise induced in VO2 was protected to a greater degree than when MO reduced Q under similar conditions. To determine if the effect of NE on VO2 was secondary to a beta-adrenergic-receptor-mediated of skeletal muscle metabolic processes, the experiments were repeated in the presence of beta-blockade with propranolol. In the presence of beta-blockade, the effects of NE on skeletal muscle VO2 were unchanged. It is therefore hypothesized that the mechanism of this effect of NE may be an increase in the efficiency of oxygen extraction resulting from a redistribution of blood flow to more active muscle fiber regions.

Oxygen consumption in skeletal muscle during reactive hyperemia

1959 ◽  
Vol 197 (1) ◽  
pp. 190-192 ◽  
Author(s):  
Lloyd R. Yonce ◽  
W. F. Hamilton
Keyword(s):  
Blood Flow ◽  
Oxygen Consumption ◽  
Time Course ◽  
Reactive Hyperemia ◽  
Control Level ◽  
Arterial Occlusion ◽  
Gracilis Muscle ◽  
Oxygen Deficit ◽  
Oxygen Difference ◽  
Increased Blood Flow

The surgical technique of isolation of the blood supply of the gracilis muscle of the dog has been developed for analysis of the oxygen consumption during reactive hyperemia. The time course of the blood flow, A-V oxygen difference and the oxygen consumption follow the same pattern. Immediately after the release of the arterial occlusion, there is an increase in all three values which decay and go below the control level that existed just prior to the occlusion. The increased oxygen consumption during reactive hyperemia is possible primarily by the increased blood flow, although the A-V oxygen difference is increased also. A theoretical oxygen deficit is overpaid by the oxygen consumption during the period of increased blood flow but essentially repaid if the period of decreased blood flow is included.

Contribution of BAT and skeletal muscle to thermogenesis induced by ephedrine in man

1985 ◽  
Vol 248 (5) ◽  
pp. E507-E515 ◽  
Author(s):  
A. Astrup ◽  
J. Bulow ◽  
J. Madsen ◽  
N. J. Christensen
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Adipose Tissue ◽  
Oxygen Consumption ◽  
Local Temperature ◽  
Whole Body ◽  
Tissue Blood Flow ◽  
Muscle Oxygen ◽  
Brown Adipose ◽  
Muscle Oxygen Consumption

This investigation was performed to examine the role of brown adipose tissue (BAT) in thermogenesis induced by ephedrine in man. Light microscopy of biopsies from necropsy cases showed BAT to occur most frequently in the perirenal fat. Perirenal BAT thermogenesis was investigated in five lean men before and during stimulation with 1 mg ephedrine orally X kg body wt-1. Perirenal BAT thermogenesis was assessed by continuous measurements of local temperature and blood flow with the 133xenon clearance method. In the same study the effect of ephedrine on skeletal muscle oxygen consumption was estimated by measurements of leg blood flow and arteriovenous oxygen difference. The perirenal adipose tissue blood flow increased approximately twofold, whereas the local temperature increased approximately 0.1 degrees C on an average. Assuming that man possesses 700 g of BAT with a similar thermogenic capacity, this tissue contributed only 10 ml X min-1 to the 40 ml X min-1 increase in oxygen consumption in the subject whose perirenal BAT showed the most pronounced response to ephedrine. The leg oxygen consumption increased on an average 60% after ephedrine. By extrapolation of this value to whole body skeletal muscle, approximately 50% of the increase in oxygen consumption induced by ephedrine may take place in skeletal muscle. It is concluded that skeletal muscle is a tissue of importance with respect to the thermogenic effect of sympathomimetics in man, whereas the results do not support a major role for perirenal BAT.

scholarly journals Simultaneous measurement of macro- and microvascular blood flow and oxygen saturation for quantification of muscle oxygen consumption

2017 ◽  
Vol 79 (2) ◽  
pp. 846-855 ◽  
Author(s):  
Erin K. Englund ◽  
Zachary B. Rodgers ◽  
Michael C. Langham ◽  
Emile R. Mohler ◽  
Thomas F. Floyd ◽  
...  
Keyword(s):  
Blood Flow ◽  
Oxygen Consumption ◽  
Oxygen Saturation ◽  
Simultaneous Measurement ◽  
Microvascular Blood Flow ◽  
Muscle Oxygen ◽  
Muscle Oxygen Consumption

Effect of short periods of arterial occlusion on blood flow and oxygen uptake

1961 ◽  
Vol 16 (5) ◽  
pp. 851-857 ◽  
Author(s):  
David I. Abramson ◽  
Samuel Tuck ◽  
Yvonne Bell ◽  
Roscoe E. Mitchell ◽  
Agenor M. Zayas
Keyword(s):  
Blood Flow ◽  
Oxygen Uptake ◽  
Reactive Hyperemia ◽  
Arterial Occlusion ◽  
Normal Subjects ◽  
Venous Occlusion ◽  
Oxygen Debt ◽  
Base Line ◽  
Vascular Change ◽  
Fick Principle

In 17 experiments, performed on the forearm of normal subjects, the effect of 2½, 5, and 10 min of arterial occlusion was studied. Blood flow was obtained with the venous occlusion plethysmograph, and oxygen uptake was calculated using the Fick principle. Arterial occlusion resulted in the production of an oxygen debt which was subsequently repaid. With progressively longer periods of anoxia there was a proportionate increase in the magnitude of the debt. Similar conclusions could not be drawn from blood flow studies alone, since the vascular change represented only one means of repayment of the oxygen debt during reactive hyperemia, the other being a greater extraction of oxygen from each unit of blood early in the postocclusion period. The constant overswing on either side of the control base line, observed in the records of oxygen uptake, suggested the absence of delicately balanced and efficient checks on the mechanisms responsible for repayment of the oxygen debt incurred in the period of tissue anoxia. Submitted on March 27, 1961

Blood flow and oxygen consumption in skeletal muscle during sympathetic stimulation

1983 ◽  
Vol 245 (1) ◽  
pp. H66-H71 ◽  
Author(s):  
L. P. Thompson ◽  
D. E. Mohrman
Keyword(s):  
Blood Flow ◽  
Oxygen Consumption ◽  
Muscle Blood Flow ◽  
Absolute Amount ◽  
Sympathetic Stimulation ◽  
Stimulation Rate ◽  
Muscle Oxygen ◽  
Somatic Nerve ◽  
Muscle Oxygen Consumption ◽  
Isometric Twitch

We studied the effects of physiological rates (0-4 Hz) of sympathetic stimulation on blood flow and oxygen consumption of extensor digitorum longus muscles isolated from anesthetized dogs. Observations were made with the preparation at rest and during isometric twitch exercise at 1 and 4 Hz produced by somatic nerve stimulation. Graded increases in sympathetic stimulation rate resulted in graded and sustained reductions in muscle blood flow in all cases. A given rate of sympathetic stimulation reduced muscle blood flow by nearly the same absolute amount regardless of muscle exercise rate. Consequently the curve relating muscle blood flow to muscle oxygen consumption was progressively shifted downward in a parallel fashion with graded increases in sympathetic stimulation rate. Sympathetic stimulation at 0.5 and 1 Hz reduced muscle oxygen consumption during 4-Hz exercise but failed to do so during rest or 1-Hz exercise. Thus even during heavy exercise, local metabolic mechanisms do not override sympathetic vasoconstriction sufficiently to prevent the latter from limiting muscle oxygen consumption. In addition, the functional consequences of sympathetic activation appear to be greater for heavily exercising muscle than resting muscle.

Contraction-by-contraction V̇o2 and computer-controlled pump perfusion as novel techniques to study skeletal muscle metabolism in situ

2010 ◽  
Vol 108 (3) ◽  
pp. 705-712 ◽  
Author(s):  
Andrés Hernández ◽  
Matthew L. Goodwin ◽  
Nicola Lai ◽  
Marco E. Cabrera ◽  
James R. McDonald ◽  
...  
Keyword(s):  
Blood Flow ◽  
Moving Average ◽  
Computer Software ◽  
Muscle Metabolism ◽  
New Techniques ◽  
Muscle Oxygen ◽  
Flow Adjustment ◽  
Train Duration ◽  
Muscle Complex

The purpose of this research was to develop new techniques to 1) rapidly sample venous O2 saturation to determine contraction-by-contraction oxygen uptake (V̇o2), and 2) precisely control the rate and pattern of blood flow adjustment from one chosen steady state to another. An indwelling inline oximeter probe connected to an Oximetrix 3 meter was used to sample venous oxygen concentration ([O2]) (via fractional saturation of Hb with O2). Data from the Oximetrix 3 were filtered, deconvolved, and processed by a moving average second by second. Computer software and a program written in-house were used to control blood flow with a peristaltic pump. The isolated canine gastrocnemius muscle complex (GS) in situ was utilized to test these techniques. A step change in metabolic rate was elicited by stimulating GS muscles via their sciatic nerves (supramaximal voltage, 8 V; 50 Hz, 0.2-ms pulse width; train duration 200 ms) at a rate of either 1 contraction/2 s, or 2 contractions/3 s. With arterial [O2] maintained constant, blood flow and calculated venous [O2] were averaged over each contraction cycle and used in the Fick equation to calculate contraction-by-contraction V̇o2. About 5–8 times more data points were obtained with this method compared with traditional manual sampling. Software-controlled pump perfusion enabled the ability to mimic spontaneous blood flow on-kinetics (τ: 14.3 s) as well as dramatically speed (τ: 2.0 s) and slow (τ: 63.3 s) on-kinetics. These new techniques significantly improve on existing methods for mechanistically altering blood flow kinetics as well as accurately measuring muscle oxygen consumption kinetics during transitions between metabolic rates.

Sign in / Sign up

Export Citation Format

Share Document