Glucose metabolism in jejunal mucosa of fed, fasted, and streptozotocin-diabetic rats

1974 ◽  
Vol 226 (1) ◽  
pp. 226-229 ◽  
Author(s):  
JW Anderson
Keyword(s):  
Glucose Metabolism ◽  
Diabetic Rats ◽  
Jejunal Mucosa ◽  
Streptozotocin Diabetic Rats

Oral salmon calcitonin enhances insulin action and glucose metabolism in diet-induced obese streptozotocin-diabetic rats

2014 ◽  
Vol 737 ◽  
pp. 91-96 ◽  
Author(s):  
Michael Feigh ◽  
Sara T. Hjuler ◽  
Kim V. Andreassen ◽  
Sofie Gydesen ◽  
Ida Ottosen ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Salmon Calcitonin ◽  
Insulin Action ◽  
Diabetic Rats ◽  
Streptozotocin Diabetic Rats

Effects of Parenteral Palatinose on Glucose Metabolism in Normal and Streptozotocin Diabetic Rats

1986 ◽  
Vol 18 (06) ◽  
pp. 361-364 ◽  
Author(s):  
Y. Okuda ◽  
K. Kawai ◽  
Y. Chiba ◽  
Y. Koide ◽  
K. Yamashita
Keyword(s):  
Glucose Metabolism ◽  
Diabetic Rats ◽  
Streptozotocin Diabetic Rats

Protein synthesis in liver and small intestine in protein deprivation and diabetes

1981 ◽  
Vol 241 (3) ◽  
pp. E238-E245 ◽  
Author(s):  
M. A. McNurlan ◽  
P. J. Garlick
Keyword(s):  
Protein Synthesis ◽  
Small Intestine ◽  
Dietary Protein ◽  
Young Male ◽  
Diabetic Rats ◽  
Male Rats ◽  
Jejunal Mucosa ◽  
Protein Deprivation ◽  
Protein Pool ◽  
Streptozotocin Diabetic Rats

Protein synthesis (as a percent of the protein pool synthesized per day) has been measured in liver and small intestine of young male rats from the incorporation of 100 mumol [1–14C]leucine/100 g body wt into protein over 10 min. Dietary protein deprivation for 8 days depressed protein synthesis in liver (30%), jejunal mucosa (20%), and jejunal serosa (25%). In serosa, reduced levels of RNA relative to protein could account for altered synthesis; in liver and mucosa, the amount of protein synthesized per unit RNA was reduced. In liver of streptozotocin-diabetic rats protein synthesis was depressed 45%, whereas it was maintained in jejunal mucosa and serosa. Depressed synthesis in liver was accompanied by both a loss of RNA relative to protein and a reduction in the protein synthesized per RNA.

Insulin binding and glucose metabolism in adipocytes of streptozotocin-diabetic rats.

1978 ◽  
Vol 235 (2) ◽  
pp. E175
Author(s):  
M Kasuga ◽  
Y Akanuma ◽  
Y Iwamoto ◽  
K Kosaka
Keyword(s):  
Glucose Metabolism ◽  
Glucose Transport ◽  
Glucose Oxidation ◽  
Insulin Receptors ◽  
Insulin Binding ◽  
Diabetic Rats ◽  
Glucose Transport System ◽  
Streptozotocin Diabetic Rats ◽  
Intracellular Glucose ◽  
Insulin Insensitivity

To investigate the mechanism of the cellular insulin insensitivity of diabetic rats, insulin binding, glucose transport, and glucose oxidation were studied in adipocytes from streptozotocin-diabetic rats. Increased insulin binding was found in cells from diabetic rats, and this was due to an increased number of insulin receptors rather than a change in receptor affinity. Basal and insulin-stimulated glucose oxidation was decreased in adipocytes from diabetic rats when the data are expressed in absolute terms or as percent increased above basal. Although the absolute rate of basal and insulin-stimulated glucose transport was decreased in adipocytes from diabetic rats, the percent increase above basal of insulin-stimulated glucose transport was not decreased. In conclusion, although the cellular insulin insensitivity exists in adipocytes from diabetic rats, the number of insulin receptors was increased, coupling between insulin receptors and the glucose transport system is intact in adipocytes from diabetic rats, and a defect in intracellular glucose metabolism rather than glucose transport plays a major role in the insulin insensitivity of adipocytes from diabetic rats.

Effects of bis(α-furancarboxylato)oxovanadium(IV) on glucose metabolism in fat-fed/streptozotocin-diabetic rats

2007 ◽  
Vol 572 (2-3) ◽  
pp. 213-219 ◽  
Author(s):  
Yanfen Niu ◽  
Weiping Liu ◽  
Changfu Tian ◽  
Mingjin Xie ◽  
Lihui Gao ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Diabetic Rats ◽  
Streptozotocin Diabetic Rats

Effects of deoxycorticosterone acetate on glucose metabolism in nondiabetic and streptozotocin-diabetic rats

1992 ◽  
Vol 70 (11) ◽  
pp. 1468-1472 ◽  
Author(s):  
Soter Dai ◽  
Heather Fraser ◽  
John H. McNeill
Keyword(s):  
Glucose Metabolism ◽  
Plasma Glucose ◽  
Plasma Insulin ◽  
Diabetic Rats ◽  
Oral Glucose ◽  
Deoxycorticosterone Acetate ◽  
Glucose Levels ◽  
Normal Glucose ◽  
Glucose Challenge ◽  
Streptozotocin Diabetic Rats

A previous study in our laboratory showed that streptozotocin (STZ) induced diabetic, deoxycorticosterone acetate (DOCA) induced hypertensive rats exhibited significantly lower levels of plasma glucose than did normotensive diabetic animals. The present experiments further investigate the effects of DOCA treatment on fasting levels of plasma glucose and insulin and on their changes after oral glucose challenge in nondiabetic and STZ-diabetic rats. It was found that, in nondiabetic rats, DOCA-induced hypertension was associated with normal glucose levels and glucose tolerance but with significantly lower levels of plasma insulin. DOCA-treated diabetic animals showed significantly lower levels of plasma glucose, but their plasma insulin concentrations were not significantly different from those of the DOCA vehicle treated diabetic rats. DOCA-treated diabetic rats also had significantly higher plasma levels of cholesterol and triglycerides. It is suggested that DOCA may have a direct or indirect action on the assimilation, production, or utilization of glucose, perhaps leading to an improvement in insulin sensitivity and subsequently a decrease in insulin secretion.Key words: glucose metabolism, insulin, deoxycorticosterone acetate, streptozotocin.

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