Effects of type 1 diabetes on reflexive cardiovascular responses to intermittent muscle contraction

2020 ◽  
Vol 319 (3) ◽  
pp. R358-R365
Author(s):  
Ann-Katrin Grotle ◽  
Yu Huo ◽  
Michelle L. Harrison ◽  
Junghoon Lee ◽  
Kai M. Ybarbo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Muscle Contraction ◽  
Type 1 Diabetes Mellitus ◽  
Early Stage ◽  
Cardiovascular Responses ◽  
Exercise Pressor Reflex ◽  
Pressor Reflex ◽  
Cardiovascular Strain

This is the first study to provide evidence that early-stage type 1 diabetes mellitus (T1DM) leads to an exaggerated exercise pressor reflex evoked by intermittent muscle contraction, resulting in substantially higher cardiovascular strain. These findings are significant as they indicate that interventions targeting the exercise pressor reflex may work to alleviate the increased cardiovascular strain and overall burden during exercise in T1DM.

GsMTx-4 normalizes the exercise pressor reflex evoked by intermittent muscle contraction in early stage type 1 diabetic rats

2021 ◽  
Vol 320 (4) ◽  
pp. H1738-H1748
Author(s):  
Ann-Katrin Grotle ◽  
Yu Huo ◽  
Michelle L. Harrison ◽  
Kai M. Ybarbo ◽  
Audrey J. Stone
Keyword(s):  
Physical Activity ◽  
Muscle Contraction ◽  
Early Stage ◽  
Diabetic Rats ◽  
Dynamic Exercise ◽  
Exercise Pressor Reflex ◽  
Pressor Reflex ◽  
Piezo Channels ◽  
Cardiovascular Strain

This is the first study to demonstrate that blocking Piezo channels is effective in ameliorating the exaggerated exercise pressor reflex evoked by intermittent muscle contraction, commonly occurring during physical activity, in T1DM. Thus, these findings suggest Piezo channels may serve as an effective therapeutic target to reduce the acute and prolonged cardiovascular strain that may occur during dynamic exercise in T1DM.

scholarly journals A case of type 1 diabetes mellitus and concomitant Hajdu-Cheney syndrome

2011 ◽  
Vol 57 (6) ◽  
pp. 35-38
Author(s):  
A V Dreval' ◽  
T S Kamynina ◽  
M N Volodina ◽  
Iu Iu Kotalevskaia ◽  
N S Demikova
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Early Stage ◽  
Russian Population ◽  
First Case ◽  
Genetically Determined

The first case of type 1 diabetes mellitus with concomitant rare genetically determined Hajdu-Cheney syndrome has been documented among the Russian population. The patient was a 26 year-old subject at the early stage of diabetes.

The Structure of Leukocyte Sialic Acid-Containing Membrane Glycoconjugates is a Differential Indicator of the Development of Diabetic Complications

2021 ◽  
Author(s):  
Iryna Brodyak ◽  
Natalia Sybirna
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Sialic Acid ◽  
Type 1 Diabetes Mellitus ◽  
Diabetic Complications ◽  
Disease Duration ◽  
Early Stage ◽  
Sialic Acids ◽  
Cellular Functions

Glycans, as potential prognostic biomarkers, deserve attention in clinical glycomics for diseases diagnosis. The variety of glycan chains, attached to proteins and lipids, makes it possible to form unique glycoconjugates with a wide range of cellular functions. Under leukocyte-endothelial interaction, not only the availability of glycoconjugates with sialic acids at the terminal position of glycans are informative, but also the type of glycosidic bond by which sialic acids links to subterminal carbohydrates in structure of glycans. The process of sialylation of leukocyte glycoconjugates undergoes considerable changes in type 1 diabetes mellitus. At early stage of disease without diabetic complications, the pathology is accompanied by the increase of α2,6-linked sialic acids. The quantity of sialic acid-containing glycoconjugates on leukocytes surface increases in condition of disease duration up to five years. However, the quantity of sialic acids linked by α2,6-glycosidic bonds decreases in patients with the disease duration over ten years. Therefore, sialoglycans as marker molecules determine the leukocyte function in patients with type 1 diabetes mellitus, depending on the disease duration. Changes in the glycans structure of membrane glycoconjugates of leukocytes allow understanding the mechanism of diabetic complications development.

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