Chewing and taste increase blood velocity in the celiac but not the superior mesenteric arteries

2008 ◽  
Vol 295 (6) ◽  
pp. R1921-R1925 ◽  
Author(s):  
Nami Someya ◽  
Naoyuki Hayashi
Keyword(s):  
Blood Flow ◽  
Superior Mesenteric Artery ◽  
Mesenteric Artery ◽  
Healthy Subjects ◽  
Celiac Artery ◽  
Blood Velocity ◽  
Mesenteric Arteries ◽  
Baseline Measurement ◽  
The Mean

To investigate the role of chewing and taste in the meal-induced rapid increase in splanchnic blood flow, we compared the blood flow responses in the celiac artery (CA) and superior mesenteric artery (SMA) to chewing solid food with a chocolate taste (FOOD) and paraffin wax without taste (WAX). After 5 min of baseline measurement, 15 healthy subjects repeated chewing and expectorating the FOOD or WAX every 20 s for 4 min followed by 10 min of recovery measurement. We measured the mean blood velocity (MBV) in the CA and SMA. The baseline MBVs in the CA and SMA did not differ between the FOOD and WAX trials. The MBV in the CA was lower than baseline at the 1st min of chewing in both trials. It was higher than baseline at the 3rd min of FOOD chewing, whereas it did not increase during and after WAX chewing. The MBV in the CA was higher in the FOOD trial than in the WAX trial at the 3rd min of chewing and thereafter. In contrast, the MBV in the SMA did not change throughout the protocols. These results suggest that the taste of food plays a role in meal-induced hyperemia in the CA but not the SMA.

scholarly journals Timing of postexercise carbohydrate-protein supplementation: roles of gastrointestinal blood flow and mucosal cell damage on gastric emptying in humans

2017 ◽  
Vol 123 (3) ◽  
pp. 606-613 ◽  
Author(s):  
Hideaki Kashima ◽  
Nao Harada ◽  
Kanae Miyamoto ◽  
Masaki Fujimoto ◽  
Chiaki Fujita ◽  
...  
Keyword(s):  
Blood Flow ◽  
Gastric Emptying ◽  
Superior Mesenteric Artery ◽  
Mesenteric Artery ◽  
Muscle Protein ◽  
Celiac Artery ◽  
Protein Supplementation ◽  
Mucosal Cell ◽  
Artery Blood Flow ◽  
Mesenteric Artery Blood Flow

It is well known that protein ingestion immediately after exercise greatly stimulates muscle protein synthesis during the postexercise recovery phase. However, immediately after strenuous exercise, the gastrointestinal (GI) mucosa is frequently injured by hypoperfusion in the organ/tissue, possibly resulting in impaired GI function (e.g., gastric emptying; GE). The aim of this study was to examine the effect of GI blood flow on the GE rate. Eight healthy young subjects performed an intermittent supramaximal cycling exercise for 30 min, which consisted of a 120% V̇o2peak for 20 s, followed by 20 W for 40 s. The subjects ingested 300 ml of a nutrient drink containing carbohydrate-protein at either 5 min postexercise in one trial (PE-5) or 30 min postexercise in another trial (PE-30). In the control trial (Con), the subjects ingested the same drink without exercise. The celiac artery blood flow (CABF) and superior mesenteric artery blood flow (SMABF) and GE rate were assessed by ultrasonography. Before drink ingestion in PE-5, CABF significantly decreased from baseline, whereas in PE-30, it returned to baseline. Following drink ingestion in PE-5, CABF did not change from baseline, but it significantly increased in PE-30 and Con. SMABF increased significantly later in PE-5 than in PE-30 and Con. The GE rate was consistently slower in PE-5 than in PE-30 and Con. In conclusion, the CABF response after exercise seems to modulate the subsequent GE rate and SMABF response. NEW & NOTEWORTHY A carbohydrate-protein drink was ingested at either 5 min (i.e., profoundly decreased celiac artery blood flow; CABF) or 30 min (i.e., already recovered CABF) postexercise. In the 5-min postexercise trial, the gastric emptying (GE) rate and superior mesenteric artery blood flow (SMABF) response were slower than those in the 30-min postexercise trial. The GE rate and SMABF response may be altered depending on the postexercise CABF response.

scholarly journals Changes of Blood Flow Volume in the Superior Mesenteric Artery and Brachial Artery with Abdominal Thermal Stimulation

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Shin Takayama ◽  
Takashi Seki ◽  
Masashi Watanabe ◽  
Shigeru Takashima ◽  
Norihiro Sugita ◽  
...  
Keyword(s):  
Blood Flow ◽  
High Resolution ◽  
Superior Mesenteric Artery ◽  
Brachial Artery ◽  
Mesenteric Artery ◽  
Healthy Subjects ◽  
Thermal Stimulation ◽  
Target Area ◽  
Flow Volume ◽  
Blood Flow Volume

In traditional Chinese medicine, moxibustion is a local thermal therapy that is used for several conditions. Quantifying the effects of moxibustion therapy has been difficult because the treatment temperature depends on the physician's experience, and the temperature distribution in the target area is not uniform. This prospective observational study aims to quantify the effect of local thermal stimulation to the abdomen. We developed a heat transfer control device (HTCD) for local thermal stimulation. Twenty-four healthy subjects were enrolled and they underwent abdominal thermal stimulation to the para-umbilical region with the device for 20 min. Blood flow volume in the superior mesenteric artery (SMA) and brachial artery (BA), the heart rate and the blood pressure were measured at rest, 15 min after starting thermal stimulation and 10, 20, 30 and 40 min after completing thermal stimulation. Blood flow parameters were measured by high-resolution ultrasound. In the SMA, blood flow volume was significantly increased during thermal stimulation (), as well as at 10 min () and 20 min () after stimulation. In the BA, blood flow volume decreased at 40 min after stimulation (). In conclusion we could quantify the effect of local thermal stimulation with an HTCD and high-resolution ultrasound. Thermal stimulation of the para-umbilical region increased blood flow in the SMA 20 min after stimulation in healthy subjects.

scholarly journals Intestinal Ischemia Mirrors Cardiac Angina- A Case Report

2021 ◽  
pp. 5-9
Author(s):  
Sunil Dighe ◽  
Kalyan Munde ◽  
Piyush Kalantri ◽  
Mahesh Bodke
Keyword(s):  
Blood Flow ◽  
Abdominal Pain ◽  
Endovascular Treatment ◽  
Mesenteric Artery ◽  
Celiac Artery ◽  
The Body ◽  
Mesenteric Arteries ◽  
Long Term Results ◽  
Chronic Mesenteric Ischemia ◽  
Interventional Devices

Chronic mesenteric ischemia (intestinal angina) is a condition that is caused by stenosis or occlusion of the mesenteric arteries (Superior mesenteric artery, inferior mesenteric artery and celiac artery) and usually manifest as abdominal pain which is usually post - prandial in nature. If plaque or lesion in an artery supplying the intestines narrows the vessel so severely that sluggish blood flow causes a clot, blood flow through that artery can become completely blocked, which can lead to ischemia .While surgical revascularization has been the standard treatment for symptomatic patients in past , recent advances in interventional devices and techniques have made endovascular treatment easily available and effective treatment. Endovascular treatment is considered as minimally invasive means of obtaining good long-term results. The Coronary arteries are common hiding places for cholesterol-filled plaque and blood clots. Plaque can limit blood flow during exercise or stress, causing the chest pain or pressure known as angina. Clots may completely block blood flow, causing a heart attack or cardiac arrest. These two leading perpetrators can do similar things elsewhere in the body. When they interfere with blood flow to the digestive system, the effects can range from a stomach ache after every meal to a life threatening emergency. We report a similar case who present with unstable angina. During hospitalization he was having persistent abdominal pain and who was investigated with CT abdomen and later Angioplasty was done which further showed significant benefit to patient.

Physician-Modified Endograft With Double Inner Branches for Urgent Repair of Supraceliac Para-Anastomotic Pseudoaneurysm

2019 ◽  
Vol 27 (1) ◽  
pp. 124-129 ◽  
Author(s):  
Mario D’Oria ◽  
Aleem K. Mirza ◽  
Emanuel R. Tenorio ◽  
Jussi M. Kärkkäinen ◽  
Randall R. DeMartino ◽  
...  
Keyword(s):  
Postoperative Complications ◽  
Superior Mesenteric Artery ◽  
Stent Graft ◽  
Mesenteric Artery ◽  
Artery Bypass ◽  
Celiac Artery ◽  
Mesenteric Arteries ◽  
Anastomotic Pseudoaneurysm ◽  
Thoracic Stent Graft

Purpose: To demonstrate the feasibility of a physician-modified endograft (PMEG) with inner branches for 2 mesenteric arteries as an alternative to fenestrations or directional branches. Technique: A symptomatic 60-year-old man presented with supraceliac para-anastomotic pseudoaneurysm involving an antegrade aorta to celiac artery and superior mesenteric artery bypass. Since an off-the-shelf multibranched endograft was inappropriate, a Zenith Alpha thoracic stent-graft was modified with 2 inner branches fashioned of 8-mm Viabahn endoprostheses with preloaded guidewires. The procedure was technically successful, and the patient had no postoperative complications. Conclusion: Inner branches might offer an alternative to fenestrations or directional branches in patients with narrow aortas.

Blood flow responses in celiac and superior mesenteric arteries in the initial phase of digestion

2008 ◽  
Vol 294 (6) ◽  
pp. R1790-R1796 ◽  
Author(s):  
Nami Someya ◽  
Masako Yamaoka Endo ◽  
Yoshiyuki Fukuba ◽  
Naoyuki Hayashi
Keyword(s):  
Blood Flow ◽  
Initial Phase ◽  
Resistance Index ◽  
Celiac Artery ◽  
Mesenteric Arteries ◽  
Baseline Measurement ◽  
Fasting State ◽  
Postprandial State ◽  
Overnight Fasting ◽  
Peak Increase

Blood flow (BF) responses in the celiac artery (CA) and superior mesenteric artery (SMA) during and immediately after a meal are poorly understood. We characterized postprandial BF responses in these arteries in the initial phase of digestion. After a baseline measurement in the overnight fasting state, healthy subjects ingested solid food (300 kcal) and water ad libitum within 5 min (4.6 ± 0.2 min, means ± SE), and then rested for 60 min in the postprandial state. Mean blood velocities (MBVs) in CA (n = 7) and SMA ( n = 9) and mean arterial pressure (MAP) were measured throughout the procedure. The MAP was divided by the MBV to yield the resistance index (RI). The MBV in CA and SMA started increasing within a minute after beginning the meal. The MBV in CA rapidly reached its peak increase (60 ± 8% change from baseline) at 5 ± 1 min after the start of the meal, whereas the MBV in SMA gradually reached its peak increase (134 ± 14%) at 41 ± 4 min after the start of the meal, reflecting a decrease in the RI for both CA and SMA. These findings suggested an earlier increase in CA and SMA MBV, implying that the increase of BF in some parts of the small intestine precedes the arrival of chyme.

IMO 1216 Effects of cerulein infusion on superior mesenteric artery blood flow (SMABF) in healthy subjects

1997 ◽  
Vol 23 ◽  
pp. S24
Author(s):  
Concetta Trombino ◽  
Maurizio Pompili ◽  
Antonio Aliotta ◽  
Roberto Luchetti ◽  
Anna Grattagliano ◽  
...  
Keyword(s):  
Blood Flow ◽  
Superior Mesenteric Artery ◽  
Mesenteric Artery ◽  
Healthy Subjects ◽  
Artery Blood Flow ◽  
Mesenteric Artery Blood Flow

scholarly journals Timing of Nutrient Ingestion after Mild to Moderate Cycling Exercise Does Not Affect Gastric Emptying Rate in Humans

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 2118
Author(s):  
Hideaki Kashima ◽  
Saori Kamimura ◽  
Ayumi Honma ◽  
Masako Yamaoka Endo ◽  
Akira Miura ◽  
...  
Keyword(s):  
Blood Flow ◽  
Gastric Emptying ◽  
Superior Mesenteric Artery ◽  
Mesenteric Artery ◽  
Plasma Insulin ◽  
Glucose Solution ◽  
Liquid Solution ◽  
Celiac Artery ◽  
Cycling Exercise ◽  
Gastric Emptying Rate

This study examined the effect of carbohydrate drink ingestion timing on gastrointestinal tract blood flow and motility after mild cycling exercise. Eight healthy participants were randomly assigned to ingest a liquid solution with 75 g glucose at either 5 min (PE-5) or 30 min (PE-30) after a single bout of leg cycling exercise according to target heart rate (approximately 120 beats/min). As the control trial (Con), participants ingested the same liquid solution without exercise. Celiac artery blood flow (BF), superior mesenteric artery BF, and gastric emptying rate were assessed by ultrasonography before and for 60 min after ingesting the glucose solution. Blood lactate, glucose, and plasma insulin were also measured at baseline and for 60 min after ingesting the glucose solution. Celiac artery BF significantly decreased from resting baseline immediately after exercise in both the PE-5 and PE-30 trials, and then returned to resting baseline just before the ingestion of glucose solution in the PE-30 trial. After ingesting the glucose solution, changes in celiac artery BF, superior mesenteric artery BF, % gastric emptying rate, blood lactate, blood glucose, and plasma insulin were not significantly different among the three trials. The timing of nutrient ingestion after mild exercise does not seem to impact the subsequent gastrointestinal motility, blood flow, and glycemic responses.

scholarly journals Mesenteric artery calcium scoring: a potential screening method for chronic mesenteric ischemia

2020 ◽  
Author(s):  
Luke G. Terlouw ◽  
Desirée van Noord ◽  
Theo van Walsum ◽  
Marco J. Bruno ◽  
Adriaan Moelker
Keyword(s):  
Superior Mesenteric Artery ◽  
Mesenteric Artery ◽  
Mesenteric Ischemia ◽  
Interobserver Agreement ◽  
Screening Tool ◽  
Screening Method ◽  
Calcium Score ◽  
Celiac Artery ◽  
Mesenteric Arteries ◽  
Chronic Mesenteric Ischemia

Abstract Objective A practical screening tool for chronic mesenteric ischemia (CMI) could facilitate early recognition and reduce undertreatment and diagnostic delay. This study explored the ability to discriminate CMI from non-CMI patients with a mesenteric artery calcium score (MACS). Methods This retrospective study included CTAs of consecutive patients with suspected CMI in a tertiary referral center between April 2016 and October 2019. A custom-built software module, using the Agatston definition, was developed and used to calculate the MACS for the celiac artery (CA), superior mesenteric artery (SMA), and inferior mesenteric artery. Scoring was performed by two blinded observers. Interobserver agreement was determined using 39 CTAs scored independently by both observers. CMI was defined as sustained symptom improvement after treatment. Non-CMI patients were patients not diagnosed with CMI after a diagnostic workup and patients not responding to treatment. Results The MACS was obtained in 184 patients, 49 CMI and 135 non-CMI. Interobserver agreement was excellent (intraclass correlation coefficient 0.910). The MACS of all mesenteric arteries was significantly higher in CMI patients than in non-CMI patients. ROC analysis of the combined MACS of CA + SMA showed an acceptable AUC (0.767), high sensitivity (87.8%), and high NPV (92.1%), when using a ≥ 29.7 CA + SMA MACS cutoff. Comparison of two CTAs, obtained in the same patient at different points in time with different scan and reconstruction parameters, was performed in 29 patients and revealed significant differences in MACSs. Conclusion MACS seems a promising screening method for CMI, but correction for scan and reconstruction parameters is warranted. Key Points • A mesenteric artery calcium score obtained in celiac artery and superior mesenteric artery has a high negative predictive value for chronic mesenteric ischemia and could serve as a screening tool. • Interobserver agreement of the mesenteric artery calcium score is excellent. • Scan and reconstruction parameters influence the mesenteric artery calcium score and warrant the development of a method to correct for these parameters.

Alterations in EDHF-type relaxation and phosphodiesterase activity in mesenteric arteries from diabetic rats

2003 ◽  
Vol 285 (1) ◽  
pp. H283-H291 ◽  
Author(s):  
Takayuki Matsumoto ◽  
Tsuneo Kobayashi ◽  
Katsuo Kamata
Keyword(s):  
Gap Junctions ◽  
Superior Mesenteric Artery ◽  
Mesenteric Artery ◽  
Matched Control ◽  
Diabetic Rats ◽  
Selective Inhibitor ◽  
Mesenteric Arteries ◽  
Phosphodiesterase Activity ◽  
Camp Phosphodiesterase

In isolated superior mesenteric artery rings from age-matched control rats and streptozotocin (STZ)-induced diabetic rats, we investigated the role of cAMP in endothelium-derived hyperpolarizing factor (EDHF)-type relaxation. The ACh-induced EDHF-type relaxation was significantly weaker in STZ-induced diabetic rats than in control rats, and in both groups of rats it was attenuated by 18α-glycyrrhetinic acid (18α-GA), an inhibitor of gap junctions, and enhanced by IBMX, a cAMP-phosphodiesterase (PDE) inhibitor. These enhanced EDHF-type responses were very similar in magnitude between diabetic and age-matched control rats. The EDHF-type relaxation was enhanced by cilostamide, a PDE3-selective inhibitor, but not by Ro 20–1724, a PDE4-selective inhibitor. The expression levels of the mRNAs and proteins for two cAMP PDEs (PDE3A, PDE3B) were significantly increased in STZ-induced diabetic rats, but those for PDE4D were not. We conclude that the impairment of EDHF-type relaxations in STZ-induced diabetic rats may be attributed to a reduction in the action of cAMP via increased PDE activity.

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