scholarly journals Prolonged poststimulation inhibition of bladder activity induced by tibial nerve stimulation in cats

2011 ◽  
Vol 300 (2) ◽  
pp. F385-F392 ◽  
Author(s):  
Changfeng Tai ◽  
Bing Shen ◽  
Mang Chen ◽  
Jicheng Wang ◽  
James R. Roppolo ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Short Duration ◽  
Nerve Stimulation ◽  
Clinical Observation ◽  
Tibial Nerve ◽  
Bladder Capacity ◽  
Inhibitory Effect ◽  
Tibial Nerve Stimulation ◽  
Bladder Symptoms ◽  
Bladder Activity

Inhibition of bladder activity by tibial nerve stimulation was investigated in α-chloralose-anesthetized cats with an intact spinal cord. Short-duration (3–5 min) tibial nerve stimulation at both low (5 Hz) and high (30 Hz) frequencies applied repeatedly during rhythmic isovolumetric bladder contractions was effective in inhibiting reflex bladder activity. Both frequencies of stimulation were also effective in inducing inhibition that persisted after the termination of the stimulation. The poststimulation inhibitory effect induced by the short-duration stimulation significantly increased bladder capacity to 181.6 ± 24.36% of the control capacity measured before applying the stimulation. Thirty-minute continuous stimulation induced prolonged poststimulation inhibition of bladder activity, which lasted for more than 2 h and significantly increased bladder capacity to 161.1 ± 2.9% of the control capacity. During the poststimulation periods, 5-Hz stimulation applied during the cystometrogram elicited a further increase (∼30% on average) in bladder capacity, but 30-Hz stimulation was ineffective. These results in cats support the clinical observation that tibial nerve neuromodulation induces a long-lasting poststimulation inhibitory effect that is useful in treating overactive bladder symptoms.

scholarly journals The long-lasting post-stimulation inhibitory effects of bladder activity induced by posterior tibial nerve stimulation in unanesthetized rats

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Eunkyoung Park ◽  
Jae-Woong Lee ◽  
Taekyung Kim ◽  
Minhee Kang ◽  
Baek Hwan Cho ◽  
...  
Keyword(s):  
Nerve Stimulation ◽  
Tibial Nerve ◽  
Inhibitory Effect ◽  
Inhibitory Response ◽  
Inhibitory Effects ◽  
Tibial Nerve Stimulation ◽  
Neurophysiological Mechanisms ◽  
Bladder Activity ◽  
Important Evidence

AbstractTibial nerve stimulation (TNS) is one of the neuromodulation methods used to treat an overactive bladder (OAB). However, the treatment mechanism is not accurately understood owing to significant differences in the results obtained from animal and clinical studies. Thus, this study was aimed to confirm the response of bladder activity to the different stimulation frequencies and to observe the duration of prolonged post-stimulation inhibitory effects following TNS. This study used unanesthetized rats to provide a closer approximation of the clinical setting and evaluated the changes in bladder activity in response to 30 min of TNS at different frequencies. Moreover, we observed the long-term changes of post-stimulation inhibitory effects. Our results showed that bladder response was immediately inhibited after 30 min of 10 Hz TNS, whereas it was excited at 50 Hz TNS. We also used the implantable stimulator to observe a change in duration of the prolonged post-stimulation inhibitory effects of the TNS and found large discrepancies in the time that the inhibitory effect lasted after stimulation between individual animals. This study provides important evidence that can be used to understand the neurophysiological mechanisms underlying the bladder inhibitory response induced by TNS as well as the long-lasting prolonged post-stimulation effect.

Effects of Bilateral Transcutaneous Tibial Nerve Stimulation on Detrusor Overactivity in Spinal Cord Injury

2018 ◽  
Vol 99 (10) ◽  
pp. e77
Author(s):  
Wasuwat Kitisomprayoonkul ◽  
Kornkamon Kamboonlert ◽  
Sirikwan Panyasriwanit ◽  
Natthiya Tantisiriwat
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Nerve Stimulation ◽  
Detrusor Overactivity ◽  
Tibial Nerve ◽  
Tibial Nerve Stimulation ◽  
Cord Injury

scholarly journals Propranolol, but not naloxone, enhances spinal reflex bladder activity and reduces pudendal inhibition in cats

2015 ◽  
Vol 308 (1) ◽  
pp. R42-R49 ◽  
Author(s):  
Marc J. Rogers ◽  
Zhiying Xiao ◽  
Bing Shen ◽  
Jicheng Wang ◽  
Zeyad Schwen ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Nerve Stimulation ◽  
Adrenergic Receptor ◽  
Bladder Capacity ◽  
Spinal Reflex ◽  
Saline Control ◽  
Tibial Nerve Stimulation ◽  
Bladder Activity ◽  
Propranolol Treatment

This study examined the role of β-adrenergic and opioid receptors in spinal reflex bladder activity and in the inhibition induced by pudendal nerve stimulation (PNS) or tibial nerve stimulation (TNS). Spinal reflex bladder contractions were induced by intravesical infusion of 0.25% acetic acid in α-chloralose-anesthetized cats after an acute spinal cord transection (SCT) at the thoracic T9/T10 level. PNS or TNS at 5 Hz was applied to inhibit these spinal reflex contractions at 2 and 4 times the threshold intensity (T) for inducing anal or toe twitch, respectively. During a cystrometrogram (CMG), PNS at 2T and 4T significantly ( P < 0.05) increased bladder capacity from 58.0 ± 4.7% to 85.8 ± 10.3% and 96.5 ± 10.7%, respectively, of saline control capacity, while TNS failed to inhibit spinal reflex bladder contractions. After administering propranolol (3 mg/kg iv, a β1/β2-adrenergic receptor antagonist), the effects of 2T and 4T PNS on bladder capacity were significantly ( P < 0.05) reduced to 64.5 ± 9.5% and 64.7 ± 7.3%, respectively, of the saline control capacity. However, the residual PNS inhibition (about 10% increase in capacity) was still statistically significant ( P < 0.05). Propranolol treatment also significantly ( P = 0.0019) increased the amplitude of bladder contractions but did not change the control bladder capacity. Naloxone (1 mg/kg iv, an opioid receptor antagonist) had no effect on either spinal reflex bladder contractions or PNS inhibition. At the end of experiments, hexamethonium (10 mg/kg iv, a ganglionic blocker) significantly ( P < 0.05) reduced the amplitude of the reflex bladder contractions. This study indicates an important role of β1/β2-adrenergic receptors in pudendal inhibition and spinal reflex bladder activity.

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