Effect of restraint on altitude tolerance in the rat

Forty adult Sprague-Dawley rats were divided into four groups: 10 control and 10 restrained animals at room temperature [Formula: see text] and 10 control and 10 restrained animals at [Formula: see text]. Continuous recordings were made on oxygen consumption and body temperature. It was learned that the restrained animals had an initially higher oxygen consumption than the control animals. This gradient was maintained throughout a three-hour exposure in the case of the animals maintained at room temperature but in the case of the animals maintained in the cold it was reversed early in the tests, i.e., the oxygen consumption of the restrained animals fell below that of the control animals. The fall in oxygen consumption was accompanied by a fall in body temperature. From the data it was not possible to state which was the cause and which was the effect. It was suggested that both decreased oxygen consumption and temperature drop may be the effect of another cause, emotionality or emotional stress.

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ŅFree roamingņ in the albino rat and its effect on restraint hypothermia

Journal of Applied Physiology ◽

10.1152/jappl.1959.14.3.393 ◽

1959 ◽

Vol 14 (3) ◽

pp. 393-394 ◽

Cited By ~ 2

Author(s):

R. G. Bartlett ◽

M. W. Young

Keyword(s):

Young Adult ◽

Emotional Stress ◽

Adult Female ◽

Cross Resistance ◽

Induced Hypothermia ◽

Sprague Dawley ◽

Albino Rat ◽

Sprague Dawley Rats ◽

Hypothermic Response ◽

Emotional Adaptation

‘Adaptation’ to a large environment increased the resistance of young adult female (175–225 gm) Sprague-Dawley rats to restraint hypothermia. Two changes may have occurred in the ‘free roaming’ rats which rendered them less susceptible to restraint hypothermia: 1) emotional adaptation to the changing stimuli of the ‘free roaming’ state may have lessened the emotional stress produced by restraint which would have reduced the hypothermic response ( Am. J. Physiol. 79: 343, 1954), 2) a possible cross-resistance produced by adaptation to the nonspecific stresses involved in the ‘free roaming’ state which would have inhibited restraint induced hypothermia ( J. Appl. Physiol. 8: 661, 1956). Submitted on September 8, 1958

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RELATIONSHIP OF OXYGEN CONSUMPTION TO BODY TEMPERATURE IN THE RESTRAINED RAT

Canadian Journal of Biochemistry and Physiology ◽

10.1139/o55-081 ◽

1955 ◽

Vol 33 (4) ◽

pp. 654-657 ◽

Cited By ~ 1

Author(s):

Roscoe G. Bartlett Jr. ◽

Vernon C. Bohr ◽

William I. Inman

Keyword(s):

Oxygen Consumption ◽

Body Temperature ◽

Emotional Stress ◽

Room Temperature ◽

Temperature Drop ◽

Sprague Dawley ◽

Sprague Dawley Rats ◽

Relationship Of

Forty adult Sprague-Dawley rats were divided into four groups: 10 control and 10 restrained animals at room temperature [Formula: see text] and 10 control and 10 restrained animals at [Formula: see text]. Continuous recordings were made on oxygen consumption and body temperature. It was learned that the restrained animals had an initially higher oxygen consumption than the control animals. This gradient was maintained throughout a three-hour exposure in the case of the animals maintained at room temperature but in the case of the animals maintained in the cold it was reversed early in the tests, i.e., the oxygen consumption of the restrained animals fell below that of the control animals. The fall in oxygen consumption was accompanied by a fall in body temperature. From the data it was not possible to state which was the cause and which was the effect. It was suggested that both decreased oxygen consumption and temperature drop may be the effect of another cause, emotionality or emotional stress.

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Ultrastructural investigation of spontaneous pituitary gonadotroph cell adenomas in aging Sprague-Dawley rats

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100077086 ◽

1983 ◽

Vol 41 ◽

pp. 702-703

Author(s):

D. J. McComb ◽

J. Beri ◽

F. Zak ◽

K. Kovacs

Keyword(s):

Electron Microscopy ◽

Animal Model ◽

Epoxy Resin ◽

Immunoelectron Microscopy ◽

Tumor Type ◽

Gonadal Function ◽

Sprague Dawley ◽

Male And Female ◽

Reticulin Fibers ◽

Sprague Dawley Rats

Gonadotroph cell adenomas of the pituitary are infrequent in human patients and are not invariably associated with altered gonadal function. To date, no animal model of this tumor type exists. Herein, we describe spontaneous gonadotroph cell adenomas in old male and female Sprague-Dawley rats by histology, immunocytology and electron microscopy.The material consisted of the pituitaries of 27 male and 38 female Sprague Dawley rats, all 26 months of age or older, removed at routine autopsy. Sections of formal in-fixed, paraffin-embedded tissue were stained with hematoxylin-phloxine-saffron (HPS), the PAS method and the Gordon-Sweet technique for the demonstration of reticulin fibers. For immunostaining, sections were exposed to anti-rat β-LH, anti-ratβ-TSH, anti-rat PRL, anti-rat GH and anti-rat ACTH 1-39. For electron microscopy, tissue was fixed in 2.5% glutaraldehyde, postfixed in 1% OsO4 and embedded in epoxy-resin. Tissue fixed in 10% formalin, embedded in epoxy resin without osmification, was used for immunoelectron microscopy.

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