RELATIONSHIP OF OXYGEN CONSUMPTION TO BODY TEMPERATURE IN THE RESTRAINED RAT

1955 ◽  
Vol 33 (1) ◽  
pp. 654-657
Author(s):  
Roscoe G. Bartlett Jr. ◽  
Vernon C. Bohr ◽  
William I. Inman
Keyword(s):  
Oxygen Consumption ◽  
Body Temperature ◽  
Emotional Stress ◽  
Room Temperature ◽  
Temperature Drop ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Relationship Of

Forty adult Sprague-Dawley rats were divided into four groups: 10 control and 10 restrained animals at room temperature [Formula: see text] and 10 control and 10 restrained animals at [Formula: see text]. Continuous recordings were made on oxygen consumption and body temperature. It was learned that the restrained animals had an initially higher oxygen consumption than the control animals. This gradient was maintained throughout a three-hour exposure in the case of the animals maintained at room temperature but in the case of the animals maintained in the cold it was reversed early in the tests, i.e., the oxygen consumption of the restrained animals fell below that of the control animals. The fall in oxygen consumption was accompanied by a fall in body temperature. From the data it was not possible to state which was the cause and which was the effect. It was suggested that both decreased oxygen consumption and temperature drop may be the effect of another cause, emotionality or emotional stress.

RELATIONSHIP OF OXYGEN CONSUMPTION TO BODY TEMPERATURE IN THE RESTRAINED RAT

1955 ◽  
Vol 33 (4) ◽  
pp. 654-657 ◽  
Author(s):  
Roscoe G. Bartlett Jr. ◽  
Vernon C. Bohr ◽  
William I. Inman
Keyword(s):  
Oxygen Consumption ◽  
Body Temperature ◽  
Emotional Stress ◽  
Room Temperature ◽  
Temperature Drop ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Relationship Of

Forty adult Sprague-Dawley rats were divided into four groups: 10 control and 10 restrained animals at room temperature [Formula: see text] and 10 control and 10 restrained animals at [Formula: see text]. Continuous recordings were made on oxygen consumption and body temperature. It was learned that the restrained animals had an initially higher oxygen consumption than the control animals. This gradient was maintained throughout a three-hour exposure in the case of the animals maintained at room temperature but in the case of the animals maintained in the cold it was reversed early in the tests, i.e., the oxygen consumption of the restrained animals fell below that of the control animals. The fall in oxygen consumption was accompanied by a fall in body temperature. From the data it was not possible to state which was the cause and which was the effect. It was suggested that both decreased oxygen consumption and temperature drop may be the effect of another cause, emotionality or emotional stress.

Effect of potassium-induced cortical spreading depression on prostaglandin-induced fever in conscious and urethane-anesthetized rats

1994 ◽  
Vol 72 (7) ◽  
pp. 716-721 ◽  
Author(s):  
I. Komaromi ◽  
T. J. Malkinson ◽  
W. L. Veale ◽  
G. Rosenbaum ◽  
K. E. Cooper ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Body Temperature ◽  
Arginine Vasopressin ◽  
Cortical Spreading Depression ◽  
Spreading Depression ◽  
Prostaglandin E ◽  
Sprague Dawley ◽  
Ambient Conditions ◽  
Sprague Dawley Rats

Potassium-induced cortical spreading depression (CSD) on prostaglandin E1 (PGE1) induced fever has been investigated in a dose-responsive experimental design in both conscious and urethane-anesthetized adult male Sprague–Dawley rats. While CSD in itself had no effect on nonfebrile body temperature even under cold ambient conditions, CSD significantly suppressed small but not large fevers induced by intracerebroventricular PGE1. The increased oxygen consumption during fever was also reduced. We also explored the possible involvement of the antipyretic peptide arginine vasopressin, in the CSD-induced suppression of fever. Long term castrated rats have significantly reduced ventral septal levels of this peptide, yet CSD was effective in suppressing the initial 40 min of PGE1 fever in these animals. Thus we conclude that increased release of ventral septal arginine vasopressin is probably not involved in the action of CSD on fever.Key words: fever, cortical spreading depression, prostaglandin, potassium, cytokines, interleukin, anesthesia, urethane.

Effect of restraint on altitude tolerance in the rat

1959 ◽  
Vol 14 (3) ◽  
pp. 395-396 ◽  
Author(s):  
R. G. Bartlett ◽  
P. D. Altland
Keyword(s):  
Oxygen Consumption ◽  
Young Adult ◽  
Emotional Stress ◽  
Simulated Altitude ◽  
Sprague Dawley ◽  
Male And Female ◽  
Experimental Animals ◽  
Sprague Dawley Rats ◽  
Altitude Tolerance ◽  
Colonic Temperature

Young adult male and female Sprague-Dawley rats were exposed to a simulated altitude of 33,500 ft. both with and without restraint. The exposure was begun immediately upon the restraint of the experimental animals. The restrained animals died significantly sooner than did the nonrestrained controls. The possible relation of colonic temperature, oxygen consumption and emotional stress to the decreased altitude tolerance is discussed. It is suggested that the data serve as a warning for caution in the use of restraint for convenience in altitude tolerance experiments. Submitted on August 6, 1958

Time course of peripheral heterothermy in a homeotherm

1980 ◽  
Vol 239 (1) ◽  
pp. R126-R129 ◽  
Author(s):  
R. T. Brown ◽  
J. G. Baust
Keyword(s):  
Room Temperature ◽  
Time Course ◽  
Temperature Fluctuations ◽  
Temperature Gradients ◽  
Tissue Temperature ◽  
Central Component ◽  
Sprague Dawley ◽  
Contralateral Limb ◽  
Sprague Dawley Rats ◽  
Peripheral Temperature

The integrity of the peripheral heterothermic response was monitored in adult Sprague-Dawley rats during cold acclimation. Subcutaneous peripheral temperature gradients were simultaneously recorded in the hindlimbs. One limb was exposed to room temperature (22 +/- 2 degrees C) while the contralateral limb was gradually cooled to 0 +/- 1 degrees C. Noncontrols were acclimated at 5 +/- 1 degrees C for periods up to 35 days. Controls responded to the cooling regimen (25 to 0 degrees C at 0.5 degrees C . min-1) in a "poikilothermic" manner indicating local cold-induced vasoconstriction (CIVC). CIVC was not released until tissue temperatures reached 22,3 +/- 2.5 degrees C whereupon nonpatterned limb temperature fluctuations, Lewis' hunting response, were often initiated. The hunting response occurred synchronously in the contralateral warmed limb despite its elevated temperature. The experiments revealed a progressive decrease in the intensity of heterothermy indicative of an earlier onset of cold-induced vasodilation as well as increased resistance to tissue cooling with increasing acclimation time. Following 21 days at 5 degrees C, limb exposure to 0 degrees C resulted in a 2-4 degrees C drop in tissue temperature. The time course of the diminution in peripheral heterothermy is discussed. In addition, evidence supporting the hypothesis of a central component in the regulation of the hunting response is presented.

Strain difference in thermoregulation of rats surviving extreme heat

1982 ◽  
Vol 52 (2) ◽  
pp. 410-415 ◽  
Author(s):  
F. Furuyama
Keyword(s):  
Body Temperature ◽  
Heat Tolerance ◽  
Strain Difference ◽  
Body Weight Loss ◽  
The Body ◽  
Sprague Dawley ◽  
Survival Times ◽  
Sprague Dawley Rats ◽  
Thermoregulatory System ◽  
Different Strains

The survival times of unanesthetized rats in 42.5 degree C. 48% rh were studied in 12 different strains. In males, Sprague-Dawley rats (P less than 0.01) and Fisher 344/MK (P less than 0.05) showed significantly higher heat tolerance than the other 9 strains. Among Sprague-Dawley rats, females tolerated heat longer than males (P less than 0.05). There was no difference in lethal body temperature according to strains and exposure temperatures (38.5–48.5 degree C). Maximum survivable body temperature was 43.1 degree C in males and 43.3 degree C in females. The body weight loss in heat was greater in Sprague-Dawley, Fisher 344/MK, and JCL:Wistar strains. The degree of saliva spreading during the equilibrium period just below the maximum survivable body temperature correlated significantly with heat tolerance and was found to be the index of strain difference in heat tolerance. These findings demonstrated that the thermoregulatory system of rats is controlled genetically, though survival times of individuals in different strains sometimes overlap.

Defect in the Renal Tubular Reabsorption of Water Associated With Potassium Depletion in Rats

1957 ◽  
Vol 189 (3) ◽  
pp. 557-563 ◽  
Author(s):  
Walter Hollander ◽  
Robert W. Winters ◽  
T. Franklin Williams ◽  
John Bradley ◽  
Jean Oliver ◽  
...  
Keyword(s):  
Urinary Concentration ◽  
Potassium Depletion ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Renal Tubular Reabsorption ◽  
Renal Concentrating Mechanism ◽  
Renal Tubular ◽  
Relationship Of ◽  
The Relationship ◽  
K Depletion

The effect of graded degrees of K depletion on the ability to produce a concentrated urine was studied in Sprague-Dawley rats. With increasing degrees of K depletion, as measured by the concentration of K in fat-free skeletal muscle, there was a progrossive decrease in the maximum urinary concentration. This defect of the renal concentrating mechanism appeared to be better correlated with the degree than with the duration of potassium depletion and could be demonstrated either by the use of exogenous vasopressin or by water deprivation. The potassium-deficient rats in at least one experiment developed a significant polydipsia. The data do not allow any conclusions with respect to the relationship of the polydipsia to the renal concentrating defect except that the latter at least was not severe at the onset of the increased water intake.

Oligomycin sensitivity of mitochondrial F1F0-ATPase in diabetes-prone BHE/Cdb rats

1999 ◽  
Vol 277 (4) ◽  
pp. E702-E707 ◽  
Author(s):  
Sook-Bae Kim ◽  
Carolyn D. Berdanier
Keyword(s):  
Mitochondrial Dna ◽  
Oxygen Consumption ◽  
Atpase Activity ◽  
Dna Sequence ◽  
Response Curve ◽  
Human Fibroblasts ◽  
Sprague Dawley ◽  
Isolated Mitochondria ◽  
Sprague Dawley Rats ◽  
Atpase 6

BHE/Cdb and Sprague-Dawley rats differ in their mitochondrial DNA sequence for the ATPase 6 (“subunit a”) gene. Base substitutions in this sequence result in the substitution of asparagine for aspartate at position 101 and the substitution of serine for leucine at position 129. Differences in sensitivity to oligomycin were observed. When the isolated F1F0-ATPase complex was studied and ATPase activity was assessed, that which was isolated from the BHE/Cdb rats was less sensitive to oligomycin inhibition than that which was isolated from the Sprague-Dawley rats. In contrast, when oxygen consumption was measured [oxygen phosphorylation (OXPHOS)] and a dose-response curve was generated with isolated mitochondria from these two strains, there was a shift to the left for the BHE/Cdb rat mitochondria. These mitochondria were more sensitive to oligomycin inhibition of OXPHOS than were mitochondria isolated from Sprague-Dawley rats. The OXPHOS results are consistent with those from human fibroblasts having either a normal or mutated ATPase 6 gene.

Body temperature response to IL-1 beta in pregnant rats

1995 ◽  
Vol 269 (5) ◽  
pp. R1179-R1182 ◽  
Author(s):  
R. L. Simrose ◽  
J. E. Fewell
Keyword(s):  
Body Temperature ◽  
Intravenous Injection ◽  
Interleukin 1 ◽  
Temperature Response ◽  
Sprague Dawley ◽  
Endogenous Pyrogen ◽  
Febrile Response ◽  
Pregnant Rats ◽  
Sprague Dawley Rats ◽  
Near Term

Rats have an attenuated or absent febrile response to exogenous pyrogen (e.g., bacterial endotoxin) near term of pregnancy. With the aim of providing insight into possible mechanism(s) of the altered febrile response to exogenous pyrogen, experiments have been carried out on 67 time-bred Sprague-Dawley rats to investigate the febrile response to endogenous pyrogen [i.e., interleukin-1 beta (IL-1 beta)]. On day 13 of gestation, intravenous injection of IL-1 beta produced a significant increase in body temperature with a latency of approximately 30 min and a duration of approximately 120 min. In contrast, on days 17 and 21 of gestation as well as on the day of delivery, intravenous injection of IL-1 beta produced significant decreases in body temperature. Thus rats do not develop fever in response to endogenous pyrogen near term of pregnancy but rather become hypothermic. The mechanism of the altered body temperature response to exogenous pyrogen as pregnancy proceeds remains unknown. We speculate, however, that it most likely lies downstream from the formation of endogenous pyrogen.

Relation of body temperature and restraint to altitude tolerance in the rat

1959 ◽  
Vol 14 (5) ◽  
pp. 785-788
Author(s):  
R. G. Bartlett ◽  
P. D. Altland
Keyword(s):  
Body Temperature ◽  
The Body ◽  
Body Temperatures ◽  
Sprague Dawley ◽  
Experimental Procedure ◽  
Altitude Exposure ◽  
Sprague Dawley Rats ◽  
Rapid Ascent ◽  
Altitude Tolerance ◽  
Oxygen Requirements

A comparison of the altitude tolerance of restrained and nonrestrained adult male (225–300 gm) and adult female (150–225 gm) Sprague-Dawley rats exposed to an altitude of 33,500 ft. at various rates of ascent with various prealtitude exposure treatments was made. Animals restrained immediately before altitude exposure with rapid ascent (2000 ft/min) to altitude die significantly sooner than do nonrestrained control animals. Slow stepwise ascent to altitude (2 ½ –4 hr. to reach terminal altitude) increased the altitude tolerance of both the restrained and nonrestrained animals but much more for the restrained animals. When body temperatures were dropped to 25℃ before altitude exposure there were no deaths (up to 6 hr.) in either the restrained or nonrestrained animals. A lesser body temperature fall provided less protection. It appears that restraint may affect altitude tolerance in the rat by hastening the body temperature fall ordinarily associated with altitude exposure and by increasing the oxygen requirements as a result of the struggling to escape restraint. Since the former increases altitude tolerance and the latter reduces it, restraint may significantly increase or significantly decrease altitude tolerance, depending on the experimental procedure. Submitted on March 4, 1959

Sign in / Sign up

Export Citation Format

Share Document