System analysis of heart rate control in man

1976 ◽  
Vol 41 (5) ◽  
pp. 790-796 ◽  
Author(s):  
I. Sato ◽  
Y. Hasegawa ◽  
K. Hotta

The dynamic property of the heart rate response to exercise was determined and expressed in the frequency domain to establish a method of examiningcardiovascular control function. The response of heart rate to a stimulus was measured at 5-s intervals in nine healthy young volunteers. The stimulusconsisted of several runs of two-step exercise practiced in semirandom sequence for 19 min. The weight function of the system was estimated from autocorrelation function of the input signal and cross-correlation function between the input and output signals. The weight function was transformed into a transfer function and its Bode plot diagram was drawn. From the diagram, four dynamic parameters were determined. These parameters are as follows: Kis a constant showing the theoretical steady-state increment of heart rate,and T1, T2, T3 are time constants. The values obtained in the present experiment with the healthy young males were: K 46.0 +/- 14.6 beats, T1, 2.12 +/- 0.44, T2, 1.12 +/- 0.16, and T3 0.70 +/- 0.07 min.

1983 ◽  
Vol 3 (5) ◽  
pp. 635-641
Author(s):  
Iwao Sato ◽  
Katsuro Shimomura ◽  
Tohru Ohe ◽  
Yasuhiro Hasegawa

1981 ◽  
Vol 36 (5) ◽  
pp. 564-572 ◽  
Author(s):  
I. Sato ◽  
Y. Hasegawa ◽  
N. Takahashi ◽  
Y. Hirata ◽  
K. Shimomura ◽  
...  

2007 ◽  
Author(s):  
E. S. Gevorkyan ◽  
S. M. Minasyan ◽  
N. N. Ksadjikyan ◽  
A. V. Dayan ◽  
TsI Adamyan

2017 ◽  
Vol 2 (6) ◽  
pp. 68-70
Author(s):  
S. Grechko ◽  
◽  
I. Trefanenko ◽  
O. Polishchuk ◽  
N. Turubarova-Leunova

Author(s):  
Lian-Yu Lin ◽  
Ting-Tse Lin ◽  
Jien-Jiun Chen ◽  
Jiunn-Lee Lin ◽  
Shoei K. Stephen Huang

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
V Kutyifa ◽  
J W Erath ◽  
A Burch ◽  
B Assmus ◽  
D Bondermann ◽  
...  

Abstract Background Previous studies highlighted the importance of adequate heart rate control in heart failure patients, and suggested under-treatment with beta-blockers especially in women. However, data on women achieving effective heart rate control during beta-blocker therapy optimization are lacking. Methods The wearable cardioverter defibrillator (WCD) allows continuous monitoring of heart rate (HR) trends during WCD use. In the current study, we assessed resting HR trends (nighttime: midnight-7am) in women, both at the beginning of WCD use and at the end of WCD use to assess the adequacy of beta-blockade following a typical 3 months of therapy optimization with beta-blockers. An adequate heart rate control was defined as having a nighttime HR <70 bpm at the end of the 3 months. Results There were a total of 21,453 women with at least 30 days of WCD use (>140 hours WCD use on the first and last week). The mean age was 67 years (IQR 58–75). The mean nighttime heart rate was 72 bpm (IQR 65–81) at the beginning of WCD use, that decreased to 68 bpm (IQR 61–76) at the end of WCD use with therapy optimization. Women had an insufficient heart rate control with resting heart rate ≥70 bpm in 59% at the beginning of WCD use that decreased to 44% at the end of WCD use, but still remained surprisingly high. Interestingly, there were 21% of the women starting with HR ≥70 bpm at the beginning of use (BOU) who achieved adequate heart rate control by the end of use (EOU). Interestingly, 6% of women with adequate heart rate control at the start of therapy optimization ended up having higher heart rates >70 bpm at the end of the therapy optimization time period (Figure). Figure 1 Conclusions A significant proportion of women with heart failure and low ejection fraction do not reach an adequate heart rate control during the time of beta blocker initiation/titration. The wearble cardioverter defibrillator is a monitoring device that has been demonstrated in this study to appropriately identify patients with inadequate heart rate control at the end of the therapy optimization period. The WCD could be utilized to improve management of beta-blocker therapy in women and improve the achievement of adequate heart rate control in women.


2016 ◽  
Vol 52 (1) ◽  
pp. 92-92
Author(s):  
Espen Skarstein Kolberg ◽  
Monica Sue-Chu ◽  
Astrid Rydning

Sign in / Sign up

Export Citation Format

Share Document