Effect of 8 wk of bicycle training on the immune system of patients with rheumatoid arthritis

1993 ◽  
Vol 75 (4) ◽  
pp. 1691-1695 ◽  
Author(s):  
B. Baslund ◽  
K. Lyngberg ◽  
V. Andersen ◽  
J. Halkjaer Kristensen ◽  
M. Hansen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Immune System ◽  
Perceived Exertion ◽  
Natural Killer Cell Activity ◽  
Interleukin 1 ◽  
Killer Cell ◽  
Plasma Concentrations ◽  
Cell Activity ◽  
Training Group ◽  
Controlled Study

The effect of 8 wk of progressive bicycle training on the immune system was evaluated in a controlled study on 18 patients with rheumatoid arthritis and moderate disease activity. Maximal O2 uptake increased significantly, whereas heart rate at stage 2 and rate of perceived exertion decreased significantly, in the training group compared with the controls. Resting levels of a number of immune parameters were measured before and after 4 and 8 wk of training. Training did not induce changes in blood mononuclear cell subpopulations, proliferative response, or natural killer cell activity. Furthermore the plasma concentrations of interleukin-1 alpha, interleukin-1 beta, and interleukin-6 did not change in response to training. It is concluded that 8 wk of bicycle training does not influence the immune system of patients with rheumatoid arthritis.

scholarly journals A Unique Enzymatically Hydrolyzed Whey Protein Positively Impacts Measures of Immunity

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1533-1533
Author(s):  
Tory Parker ◽  
Anna Andersen ◽  
David Vollmer
Keyword(s):  
Immune System ◽  
Nutritive Value ◽  
Nk Cell ◽  
Natural Killer Cell Activity ◽  
Killer Cell ◽  
Cell Activity ◽  
Milk Proteins ◽  
Transfer Factors ◽  
Funding Sources ◽  
Immunological Research

Abstract Objectives Milk proteins appear to have little direct impact on the immune system when consumed directly. The digestive system breaks them down into absorbable size and they provide nutritive value. However, it has been discovered that enzymatically hydrolyzed peptides can more directly influence the immune system, presumably before digestion completes their hydrolysis during gut immune system exposure. The term ‘bioactive centers’ will be used to describe these unique peptides. Methods After screening several different versions of enzyme hydrolyzed whey, a new bioactive center-containing product was found that had promise for further immunological research. It was compared against transfer factors, 4Life Research's colostrum filtrate, which have previously been studied for their immune activity. Results In a natural killer cell activity assay, the bioactive centers product was significantly (70%) more effective than IL-2, the standard stimulant, and equally as effective as transfer factors. A second experiment confirmed that this effect was consistent across different production batches of the product. A third experiment found that a combination of the bioactive centers and transfer factors enhanced the activity by 10% on average. In a second study, the bioactive centers were evaluated in a mouse model. They were as effective as transfer factors in stimulating NK cell activity, antibody production, TNF-alpha and IL-2 production, and in stimulating phagocytosis. In most cases, results were higher, though not statistically significantly so, for the transfer factor/bioactive centers combination. Conclusions Since the discovery of transfer factors, work both in and outside of 4Life Research has continued to try to identify new approaches to positively impacting the immune system. These results show that bioactive centers from whey can have such activity. Further work is needed to fully understand their impact in human health. Funding Sources 4Life Research.

Immunopharmacology of Chinese Medicine 1, Ginseng Induced Immunosuppression In Virus-Infected Mice

1982 ◽  
Vol 10 (01n04) ◽  
pp. 44-54 ◽  
Author(s):  
H.W. Yeung ◽  
K. Cheung ◽  
K.N. Leung
Keyword(s):  
Body Weight ◽  
Influenza Virus ◽  
Immune System ◽  
Natural Killer Cell Activity ◽  
Killer Cell ◽  
Cell Activity ◽  
Delayed Type Hypersensitivity ◽  
Cytotoxic T Cell ◽  
Killer Cell Activity ◽  
Activity Induction

Total saponins extracted from Panax ginseng, when injected into mice at a dose of approximately 10 mg/kg body weight, have no significant effect on the generation of cytotoxic T cell activity, induction of natural killer cell activity and humoral antibody production in mice infected subsequently with A/WSN influenza virus. The saponins, however, selectively suppressed the delayed-type hypersensitivity responses to the virus when administrated to the animals before but not after virus sensitization. Thus, ginseng pretreatment can induce immunological unresponsiveness in one arm of the immune system. Such selective immunosuppression effect of the total saponins of ginseng may be related to their steroid-like structure.

scholarly journals Evidence-Based Review of BioBran/MGN-3 Arabinoxylan Compound as a Complementary Therapy for Conventional Cancer Treatment

2017 ◽  
Vol 17 (2) ◽  
pp. 165-178 ◽  
Author(s):  
Soo Liang Ooi ◽  
Debbie McMullen ◽  
Terry Golombick ◽  
Dipl Nut ◽  
Sok Cheon Pak
Keyword(s):  
Immune System ◽  
Cancer Treatment ◽  
Treatment Outcomes ◽  
Natural Killer Cell Activity ◽  
Killer Cell ◽  
Cell Activity ◽  
Complementary Therapy ◽  
Chemotherapeutic Agents ◽  
Sufficient Evidence ◽  
Conventional Cancer Treatment

Introduction: Conventional cancer treatment, including surgery, chemotherapy, and radiotherapy, may not be sufficient to eradicate all malignant cells and prevent recurrence. Intensive treatment often leads to a depressed immune system, drug resistance, and toxicity, hampering the treatment outcomes. BioBran/MGN-3 Arabinoxylan is a standardized arabinoxylan concentrate which has been proposed as a plant-based immunomodulator that can restore the tumor-induced disturbance of the natural immune system, including natural killer cell activity to fight cancer, complementing conventional therapies. Objectives: To comprehensively review the available evidence on the effects and efficacies of MGN-3 as a complementary therapy for conventional cancer treatment. Methods: Systematic search of journal databases and gray literature for primary studies reporting the effects of MGN-3 on cancer and cancer treatment. Results: Thirty full-text articles and 2 conference abstracts were included in this review. MGN-3 has been shown to possess immunomodulating anticancer effects and can work synergistically with chemotherapeutic agents, in vitro. In murine models, MGN-3 has been shown to act against carcinogenic agents, and inhibit tumor growth, either by itself or in combination with other anticancer compounds. Fourteen successful MGN-3 treated clinical cases were found. Eleven clinical studies, including 5 nonrandomized, pre-post intervention studies and 6 randomized controlled trials (RCTs) were located. Reported effects include enhanced immunoprofile, reduced side effects, improved treatment outcomes; one RCT established significantly increased survival rates. There are no reports on adverse events on MGN-3. Most of the clinical trials are small studies with short duration. Conclusion: There is sufficient evidence suggesting MGN-3 to be an effective immunomodulator that can complement conventional cancer treatment. However, more well-designed RCTs on MGN-3 are needed to strengthen the evidence base.

scholarly journals Vaccinia virus lacking the Bcl-2-like protein N1 induces a stronger natural killer cell response to infection

2008 ◽  
Vol 89 (11) ◽  
pp. 2877-2881 ◽  
Author(s):  
Nathalie Jacobs ◽  
Nathan W. Bartlett ◽  
Richard H. Clark ◽  
Geoffrey L. Smith
Keyword(s):  
Natural Killer Cell ◽  
Vaccinia Virus ◽  
Natural Killer ◽  
Natural Killer Cell Activity ◽  
Interleukin 1 ◽  
Killer Cell ◽  
Cell Activity ◽  
Cytotoxic T Cell ◽  
Cd69 Expression ◽  
Natural Killer Cell Response

The vaccinia virus (VACV) N1 protein is an intracellular virulence factor that has a Bcl-2-like structure and inhibits both apoptosis and signalling from the interleukin 1 receptor, leading to nuclear factor kappa B activation. Here, we investigated the immune response to intranasal infection with a virus lacking the N1L gene (vΔN1L) compared with control viruses expressing N1L. Data presented show that deletion of N1L did not affect the proportion of CD4+ and CD8+ T cells infiltrating the lungs or the cytotoxic T-cell activity of these cells. However, vΔN1L induced an increased local natural killer cell activity between days 4 and 6 post-infection. In addition, in the absence of N1 the host inflammatory infiltrate was characterized by a reduced proportion of lymphocytes bearing the early activation marker CD69. Notably, there was a good correlation between the level of CD69 expression and weight loss. The implications of these findings are discussed.

Circadian Abnormalities of Natural Killer Cell Activity in Rheumatoid Arthritis

1999 ◽  
Vol 876 (1 NEUROENDOCRIN) ◽  
pp. 88-90
Author(s):  
R. G. MASERA ◽  
R. CARIGNOLA ◽  
M. L. SARTORI ◽  
A. H. STAURENGHI ◽  
A. ANGELI
Keyword(s):  
Rheumatoid Arthritis ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Natural Killer Cell Activity ◽  
Killer Cell ◽  
Cell Activity ◽  
Killer Cell Activity
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