Validity of fan-beam dual-energy X-ray absorptiometry for measuring fat-free mass and leg muscle mass

1999 ◽  
Vol 87 (4) ◽  
pp. 1513-1520 ◽  
Author(s):  
Marjolein Visser ◽  
Thomas Fuerst ◽  
Thomas Lang ◽  
Loran Salamone ◽  
Tamara B. Harris ◽  
...  
Keyword(s):  
Muscle Mass ◽  
Dual Energy ◽  
Fat Free Mass ◽  
Elderly Persons ◽  
X Ray ◽  
Total Body Fat ◽  
The Mean ◽  
Leg Muscle ◽  
The Difference ◽  
Total Body

The aim of the study was to examine the accuracy of fan-beam dual-energy X-ray absorptiometry (DEXA) for measuring total body fat-free mass (FFM) and leg muscle mass (MM) in elderly persons. Participants were 60 men and women aged 70–79 yr and with a body mass index of 17.5–39.8 kg/m2. FFM and MM at four leg regions were measured by using DEXA (Hologic 4500A, v8.21). A four-compartment body composition model (4C) and multislice computed tomography (CT) of the legs were used as the criterion methods for FFM and MM, respectively. FFM by DEXA was positively associated with FFM by 4C ( R 2 = 0.98, SE of estimate = 1.6 kg). FFM by DEXA was higher [53.5 ± 12.0 (SD) kg] than FFM by 4C (51.6 ± 11.9 kg; P < 0.001). No association was observed between the difference and the mean of the two methods. MM by DEXA was positively associated with CT at all four leg regions ( R 2 = 0.86–0.96). MM by DEXA was higher than by CT in three regions. The results of this study suggest that fan-beam DEXA offers considerable promise for the measurement of total body FFM and leg MM in elderly persons.

scholarly journals Evaluation of a model for total body protein mass based on dual-energy X-ray absorptiometry: comparison with a reference four-component model

2001 ◽  
Vol 86 (1) ◽  
pp. 45-52 ◽  
Author(s):  
N. J. Fuller ◽  
J. C. K. Wells ◽  
M. Elia
Keyword(s):  
Dual Energy ◽  
Fat Free Mass ◽  
Component Model ◽  
Body Volume ◽  
Body Protein ◽  
X Ray ◽  
Protein Mass ◽  
Four Component Model ◽  
The Mean ◽  
Total Body

The aim of the present study was to evaluate a model of body composition for assessing total body protein (TBP) mass using dual-energy X-ray absorptiometry (DXA), with either measured or assumed total body water (TBW); it was intended to provide a less complex or demanding alternative technique to, for example, the four-component model (4-CM). The following measurements were obtained in healthy adults (n46) aged 18–62 years, and children (n30) aged 8–12 years: body weight (BWt), body volume (BV; under-water weighing), TBW (2H-dilution space or predicted using an assumed hydration fraction of fat-free mass (HFffm)), bone mineral content (BMC; DXA) and fat-free soft tissue (FFST; DXA). TBP was calculated using the 4-CM (TBP=3·050BWt-0·290TBW-2·734BMC-2·747BV) and the DXA model (TBP=FFST-0·2305BMC-TBW). DXA measurements were obtained using the Lunar DPX (Lunar Radiation Corporation, Madison, WI, USA) or Hologic QDR 1000/W (Hologic, Waltham, MA, USA). Precision of the DXA model for TBP with measured TBW (4·6–6·8 % mean TBP) was slightly worse than the 4-CM (4·0–5·4 %), whereas that modelled with assumed HFffmwas more precise (2·4–5·2 %) because it obviated imprecision associated with measuring TBW. Agreement between the 4-CM and DXA model with measured TBW was also worse (e.g. bias, 15 % of the mean; 95 % limits of agreement up to ±39 % for adults measured on the Lunar DPX) than when a constant for HFffmwas assumed (3·7 % and ±21 % respectively). Most of the variability in agreement between these various models was due to interpretation of biological factors, rather than to measurement imprecision. Therefore, the DXA model, which is less complex and demanding than the 4-CM, is of value for assessing TBP in groups of healthy subjects, but is of less value for individuals in whom there may be substantial differences from reference 4-CM estimates.

scholarly journals AB0267 BODY COMPOSITION IN PATIENTS WITH RHEUMATOID ARTHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1432.2-1432
Author(s):  
N. Toroptsova ◽  
O. Dobrovolskaya ◽  
N. Demin ◽  
L. Shornikova
Keyword(s):  
Rheumatoid Arthritis ◽  
Body Composition ◽  
Muscle Mass ◽  
Dual Energy ◽  
X Ray ◽  
T Score ◽  
Osteosarcopenic Obesity ◽  
The Mean ◽  
Total Fat ◽  
Appendicular Muscle Mass

Background:Rheumatoid arthritis (RA) is a complex inflammatory disease that modifies body composition. Using the dual-energy x-ray absorptiometry (DXA) in RA patients could be a method for body composition changes detection.Objectives:To study the body composition using DXA in patients with RA.Methods:The study involved 79 women with RA, median age 60 [55; 65] years. The bone mineral density (BMD) was measured by dual-energy x-ray absorptiometry using «Discovery A» (Hologic, USA). Assessment of body composition was carried out, using the program «Whole body». Sarcopenia (SP) was diagnosed as a decrease in appendicular mass index (AMI) <6.0 kg/m2. Osteoporosis (OP) was diagnosed as a decrease in T-score <-2.5 SD. Osteosarcopenia was determined when T-score was <-1.0 SD, AMI was <6.0 kg/m2, osteosarcopenic obesity - T-score was <-1.0 SD, AMI was <6.0 kg/m2and total fat was >35%.Results:The mean duration of RA was 9 [3; 11] years. The mean body mass index (BMI) was 27.6±4.8 kg/m2. Disease activity score in 28 joints-erythrocyte sedimentation rate was 4.5±1.3 points for the group. 39 (49.3%) patients used oral glucocorticoids continuously. Appendicular muscle mass and AMI were on average 17.8±3.0 kg and 6.8±1.0 kg/m2, respectively. AMI <6 kg/m2was detected in 20 (25.3%) patients. 56 (70.9%) women with RA had total fat > 35%, while only 22 (27.8%) of women with RA had obesity according to BMI (BMI >30 kg/m2). Isolated OP was found in 13 (16.5%), osteosarcopenia in 7 (8.9%) and osteosarcopenic obesity in 13 (16.5%) patients RA. No cases with isolated sarcopenia or sarcopenic obesity were detected. Only 3 (3.8%) patients did not have appendicular muscle mass, AMI and BMD decrease and overfat or obesity.Conclusion:About 97% women with RA had abnormal body composition phenotype: 16,5% - OP, 8.9% -osteosarcopenia, 16,5% - osteosarcopenic obesity and 54,4% - overfat.Disclosure of Interests:None declared

scholarly journals Creatine (methyl-d3) dilution in urine for estimation of total body skeletal muscle mass: accuracy and variability vs. MRI and DXA

2018 ◽  
Vol 124 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Richard V. Clark ◽  
Ann C. Walker ◽  
Ram R. Miller ◽  
Robin L. O’Connor-Semmes ◽  
Eric Ravussin ◽  
...  
Keyword(s):  
Muscle Mass ◽  
Dual Energy ◽  
Intraindividual Variability ◽  
Whole Body ◽  
Dilution Method ◽  
X Ray ◽  
Spot Urine ◽  
Spot Urine Sample ◽  
Liquid Chromatography Tandem Mass ◽  
Total Body

A noninvasive method to estimate muscle mass based on creatine ( methyl-d3) (D3-creatine) dilution using fasting morning urine was evaluated for accuracy and variability over a 3- to 4-mo period. Healthy older (67- to 80-yr-old) subjects ( n = 14) with muscle wasting secondary to aging and four patients with chronic disease (58–76 yr old) fasted overnight and then received an oral 30-mg dose of D3-creatine at 8 AM ( day 1). Urine was collected during 4 h of continued fasting and then at consecutive 4- to 8-h intervals through day 5. Assessment was repeated 3–4 mo later in 13 healthy subjects and 1 patient with congestive heart failure. Deuterated and unlabeled creatine and creatinine were measured using liquid chromatography–tandem mass spectrometry. Total body creatine pool size and muscle mass were calculated from D3-creatinine enrichment in urine. Muscle mass was also measured by whole body MRI and 24-h urine creatinine, and lean body mass (LBM) was measured by dual-energy X-ray absorptiometry (DXA). D3-creatinine urinary enrichment from day 5 provided muscle mass estimates that correlated with MRI for all subjects ( r = 0.88, P < 0.0001), with less bias [difference from MRI = −3.00 ± 2.75 (SD) kg] than total LBM assessment by DXA, which overestimated muscle mass vs. MRI (+22.5 ± 3.7 kg). However, intraindividual variability was high with the D3-creatine dilution method, with intrasubject SD for estimated muscle mass of 2.5 kg vs. MRI (0.5 kg) and DXA (0.8 kg). This study supports further clinical validation of the D3-creatine method for estimating muscle mass. NEW & NOTEWORTHY Measurement of creatine ( methyl-d3) (D3-creatine) and D3-creatinine excretion in fasted morning urine samples may be a simple, less costly alternative to MRI or dual-energy X-ray absorptiometry (DXA) to calculate total body muscle mass. The D3-creatine enrichment method provides estimates of muscle mass that correlate well with MRI, and with less bias than DXA. However, intraindividual variability is high with the D3-creatine method. Studies to refine the spot urine sample method for estimation of muscle mass may be warranted.

Total-body skeletal muscle mass: estimation by a new dual-energy X-ray absorptiometry method

2002 ◽  
Vol 76 (2) ◽  
pp. 378-383 ◽  
Author(s):  
Jaehee Kim ◽  
ZiMian Wang ◽  
Steven B Heymsfield ◽  
Richard N Baumgartner ◽  
Dympna Gallagher
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Dual Energy ◽  
Mass Estimation ◽  
X Ray ◽  
Total Body

QDR 4500A DXA overestimates fat-free mass compared with criterion methods

2003 ◽  
Vol 94 (3) ◽  
pp. 959-965 ◽  
Author(s):  
Frances Tylavsky ◽  
Timothy Lohman ◽  
Barbara A. Blunt ◽  
Dale A. Schoeller ◽  
Thomas Fuerst ◽  
...  
Keyword(s):  
Lower Estimate ◽  
Dual Energy ◽  
Fat Free Mass ◽  
Component Model ◽  
Men And Women ◽  
Hydration Level ◽  
X Ray ◽  
Beam System ◽  
Four Component Model ◽  
Total Body

This study evaluated the accuracy with which the dual-energy X-ray absorptiometer (Hologic QDR 4500A) measured fat-free mass (FFM), fat mass (FM), and hydration of FFM. In a study of 58 men and women (ages 70–79 yr), the QDR 4500A was found to provide a systematically higher estimate of FFM and lower estimate of FM than a four-component model of body composition. A correction factor from this study was developed and applied to two other samples ( n = 13 and 37). We found mean corrected levels of FFM and FM to be equivalent to that obtained by the four-component model or total body water. In addition, the hydration of the corrected FFM was closer to the established hydration level in adult samples and that obtained from the four-component model. These findings suggest that the current calibration of the fan-beam system of the Hologic QDR 4500A provides an overestimate of FFM and underestimate of FM compared with reference methods.

scholarly journals Estimation of body composition from bioelectrical impedance of body segments: Comparison with dual-energy X-ray absorptiometry

1993 ◽  
Vol 69 (3) ◽  
pp. 645-655 ◽  
Author(s):  
S. P. Stewart ◽  
P. N. Bramley ◽  
R. Heighton ◽  
J. H. Green ◽  
A. Horsman ◽  
...  
Keyword(s):  
Body Composition ◽  
Muscle Mass ◽  
Bioelectrical Impedance ◽  
Dual Energy ◽  
Fat Free Mass ◽  
Whole Body ◽  
Simple Method ◽  
Creatinine Excretion ◽  
X Ray ◽  
Body Segments

In twenty-eight healthy subjects, ten men and eighteen women, with a range in body mass index (BMI) of 17.9–31.6 kg/m2 and an age range 20–60 years, body composition was estimated by dual-energy X-ray absorptiometry (DEXA), skinfold anthropometry (SFA) and bioelectrical impedance analysis (BIA) of the ‘whole body’and body segments. In thirteen subjects muscle mass was also estimated by 24 h urinary creatinine excretion. The relationship between fat-free mass (FFM) determined by DEXA and the impedance index of each body segment (calculated as Iength2/impedance (Z)) was analysed. The strongest correlation was between FFM (DEXA) and height2/‘whole-body’Z (Zw) (r 0.97 for the combined sexes, standard error of estimate (SEE) 2.72 kg). Separate prediction equations were found to be necessary for males and females when estimating FFM from BIA measurement of the arm (for men, r 0.93, SEE 1.98 kg; for women, r 0.75, SEE 2.87 kg). Muscle mass derived from 24 h creatinine excretion showed weak correlation with FFM (DEXA) (r 0.57, P = 0.03) and no correlation with FFM (SFA). FFM (SFA) correlated well with both FFM (DEXA) (r 0.96, SEE = 3.12 kg) and with height2/Zw (r 0.92, SEE 4.52 kg). Measurement of the impedance of the arm offers a simple method of assessing the composition of the whole body in normal individuals, and it appears comparable with other methods of assessment.

scholarly journals Total-body skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in children and adolescents

2006 ◽  
Vol 84 (5) ◽  
pp. 1014-1020 ◽  
Author(s):  
Jaehee Kim ◽  
Wei Shen ◽  
Dympna Gallagher ◽  
Alfredo Jones ◽  
ZiMian Wang ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Children And Adolescents ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Dual Energy ◽  
Mass Estimation ◽  
X Ray ◽  
Total Body
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