Physiological evaluation of a new quantitative SPECT method measuring regional ventilation and perfusion

2004 ◽  
Vol 96 (3) ◽  
pp. 1127-1136 ◽  
Author(s):  
Johan Petersson ◽  
Alejandro Sánchez-Crespo ◽  
Malin Rohdin ◽  
Stéphanie Montmerle ◽  
Sven Nyrén ◽  
...  
Keyword(s):  
Gas Exchange ◽  
Single Photon ◽  
Photon Emission ◽  
Inert Gas ◽  
Emission Computed Tomography ◽  
Regional Ventilation ◽  
Quantitative Spect ◽  
Respiratory Gases ◽  
Photon Emission Computed Tomography ◽  
Ventilation And Perfusion

We have developed a new quantitative single-photon-emission computed tomography (SPECT) method that uses 113mIn-labeled albumin macroaggregates and Technegas (99mTc) to estimate the distributions of regional ventilation and perfusion for the whole lung. The multiple inert-gas elimination technique (MIGET) and whole lung respiratory gas exchange were used as physiological evaluations of the SPECT method. Regional ventilation and perfusion were estimated by SPECT in nine healthy volunteers during awake, spontaneous breathing. Radiotracers were administered with subjects sitting upright, and SPECT images were acquired with subjects supine. Whole lung gas exchange of MIGET gases and arterial Po2 and Pco2 gases was predicted from estimates of regional ventilation and perfusion. We found a good agreement between measured and SPECT-predicted exchange of MIGET and respiratory gases. Correlations ( r2) between SPECT-predicted and measured inert-gas excretions and retentions were 0.99. The method offers a new tool for measuring regional ventilation and perfusion in humans.

scholarly journals Quantitative bone single-photon emission computed tomography imaging for uninfected nonunion: comparison of hypertrophic nonunion and non-hypertrophic nonunion

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Keisuke Oe ◽  
Feibi Zeng ◽  
Tomoaki Fukui ◽  
Munenobu Nogami ◽  
Takamichi Murakami ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Single Photon Emission ◽  
Quantitative Spect ◽  
Quantitative Parameters ◽  
Emission Computed ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography

Abstract Background Recently, a standardized uptake value (SUV) has been used to evaluate bone single-photon emission computed tomography (SPECT). The aim of this study was to investigate quantitative SPECT imaging of uninfected nonunion to compare hypertrophic nonunion and non-hypertrophic nonunion using volume-based parameters. Methods We evaluated 23 patients with uninfected nonunion who underwent SPECT acquisition 3 h after an injection of 99mTc-hydroxymethylene diphosphonate or 99mTc-methylene diphosphonate from April 2014 to November 2019. We reconstructed the acquired data and performed voxel-based quantitative analysis using the GI-BONE software. Quantitative parameters, maximum SUV (SUVmax), peak SUV (SUVpeak), and mean SUV (SUVmean) in the high and low uptake areas of nonunion were compared between hypertrophic nonunion and non-hypertrophic nonunion. The contralateral limb was used as a control, and the ratios of the quantitative parameters were calculated. Results The values for the quantitative parameters (high uptake area/low uptake area, respectively), SUVmax control ratio (12.13 ± 4.95/6.44 ± 4.71), SUVpeak control ratio (11.65 ± 4.58/6.45 ± 4.64), and SUVmean control ratio (11.94 ± 5.03/6.28 ± 4.95) for hypertrophic nonunion were higher than those for non-hypertrophic nonunion (7.82 ± 4.76/3.41 ± 2.09 (p = 0.065/0.12), 7.56 ± 4.51/3.61 ± 2.23 (p = 0.065/0.22), and 7.59 ± 5.18/3.05 ± 1.91 (p = 0.076/0.23)). Conclusions SUVmax, SUVpeak, and SUVmean control ratios obtained from bone SPECT images can quantitatively evaluate the biological activity of nonunions and may be an effective evaluation method for treatment decisions, especially the necessity of autologous bone grafting.

scholarly journals Quantitative Bone Single Photon Emission Computed Tomography Imaging for Uninfected Nonunion: Comparison of Hypertrophic Nonunion and Non-Hypertrophic Nonunion

2020 ◽  
Author(s):  
Keisuke Oe ◽  
Feibi Zeng ◽  
Tomoaki Fukui ◽  
Munenobu Nogami ◽  
Takamichi Murakami ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Single Photon Emission ◽  
Quantitative Spect ◽  
Quantitative Parameters ◽  
Emission Computed ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography

Abstract BackgroundRecently, a standardized uptake value (SUV) has been used to evaluate bone single photon emission computed tomography (SPECT). The aim of this study was to investigate quantitative SPECT imaging of uninfected nonunion to compare hypertrophic nonunion and non-hypertrophic nonunion using volume-based parameters.MethodsWe evaluated 23 patients with uninfected nonunion who underwent SPECT acquisition 3 h after an injection of 99mTc-hydroxymethylene diphosphonate or 99mTc-methylene diphosphonate from April 2014 to November 2019. We reconstructed the acquired data and performed voxel-based quantitative analysis using GI-BONE software. Quantitative parameters, maximum SUV (SUVmax), peak SUV (SUVpeak), and mean SUV (SUVmean) in the high and low uptake areas of nonunion were compared between hypertrophic nonunion and non-hypertrophic nonunion. The contralateral limb was used as a control, and the ratios of the quantitative parameters were calculated. ResultsThe values for the quantitative parameters (high uptake area/low uptake area, respectively), SUVmax control ratio (12.13 ± 4.95/6.44 ± 4.71), SUVpeak control ratio (11.65 ± 4.58/6.45 ± 4.64), and SUVmean control ratio (11.94 ± 5.03/6.28 ± 4.95) for hypertrophic nonunion were higher than those for non-hypertrophic nonunion (7.82 ± 4.76/3.41 ± 2.09 (p = 0.065/0.12), 7.56 ± 4.51/3.61 ± 2.23 (p = 0.065/0.22), and 7.59 ± 5.18/3.05 ± 1.91 (p = 0.076/0.23). ConclusionsSUVmax, peak, mean control ratios obtained from bone SPECT images can quantitatively evaluate the biological activity of nonunions and may be an effective evaluation method for treatment decisions, especially the necessity of autologous bone grafting.

V˙/Q˙ distribution and correlation to atelectasis in anesthetized paralyzed humans

1996 ◽  
Vol 81 (4) ◽  
pp. 1822-1833 ◽  
Author(s):  
Leif Tokics ◽  
Göran Hedenstierna ◽  
Leif Svensson ◽  
Bo Brismar ◽  
Torsten Cederlund ◽  
...  
Keyword(s):  
Computerized Tomography ◽  
Single Photon ◽  
Photon Emission ◽  
Inert Gas ◽  
Dependent Lung ◽  
Single Photon Emission ◽  
Regional Ventilation ◽  
Ventilation And Perfusion

Tokics, Leif, Göran Hedenstierna, Leif Svensson, Bo Brismar, Torsten Cederlund, Hans Lundquist, and Åke Strandberg. V˙/Q˙ distribution and correlation to atelectasis in anesthetized paralyzed humans. J. Appl. Physiol. 81(4): 1822–1833, 1996.—Regional ventilation and perfusion were studied in 10 anesthetized paralyzed supine patients by single-photon emission computerized tomography. Atelectasis was estimated from two transaxial computerized tomography scans. The ventilation-perfusion (V˙/Q˙) distribution was also evaluated by multiple inert gas elimination. While the patients were awake, inert gas V˙/Q˙ ratio was normal, and shunt did not exceed 1% in any patient. Computerized tomography showed no atelectasis. During anesthesia, shunt ranged from 0.4 to 12.2%. Nine patients displayed atelectasis (0.6–7.2% of the intrathoracic area), and shunt correlated with the atelectasis ( r = 0.91, P < 0.001). Shunt was located in dependent lung regions corresponding to the atelectatic area. There was considerable V˙/Q˙ mismatch, with ventilation mainly of ventral lung regions and perfusion of dorsal regions. Little perfusion was seen in the most ventral parts (zone 1) of caudal (diaphragmatic) lung regions. In summary, shunt during anesthesia is due to atelectasis in dependent lung regions. TheV˙/Q˙ distributions differ from those shown earlier in awake subjects.

Imaging regional PaO2 and gas exchange

2012 ◽  
Vol 113 (2) ◽  
pp. 340-352 ◽  
Author(s):  
Johan Petersson ◽  
Robb W. Glenny
Keyword(s):  
Blood Flow ◽  
Gas Exchange ◽  
Spatial Resolution ◽  
Photon Emission ◽  
Repeated Measurements ◽  
Emission Computed Tomography ◽  
Regional Ventilation ◽  
Imaging Methods ◽  
Stage Of Development ◽  
Ventilation And Perfusion

Several methods allow regional gas exchange to be inferred from imaging of regional ventilation and perfusion (V/Q) ratios. Each method measures slightly different aspects of gas exchange and has inherent advantages and drawbacks that are reviewed. Single photon emission computed tomography can provide regional measure of ventilation and perfusion from which regional V/Q ratios can be derived. PET methods using inhaled or intravenously administered nitrogen-13 provide imaging of both regional blood flow, shunt, and ventilation. Electric impedance tomography has recently been refined to allow simultaneous measurements of both regional ventilation and blood flow. MRI methods utilizing hyperpolarized helium-3 or xenon-129 are currently being refined and have been used to estimate local PaO2 in both humans and animals. Microsphere methods are included in this review as they provide measurements of regional ventilation and perfusion in animals. One of their advantages is their greater spatial resolution than most imaging methods and the ability to use them as gold standards against which new imaging methods can be tested. In general, the reviewed methods differ in characteristics such as spatial resolution, possibility of repeated measurements, radiation exposure, availability, expensiveness, and their current stage of development.

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