Equol producing status affects exercise training-induced improvement in arterial compliance in postmenopausal women

2020 ◽  
Author(s):  
Koichiro Hayashi ◽  
Hidetaka Yamaguchi ◽  
Hiroshi Amaoka ◽  
Terumasa Takahara ◽  
Shiori Kunisa ◽  
...  
Keyword(s):  
Exercise Training ◽  
Aerobic Exercise ◽  
Postmenopausal Women ◽  
Interaction Effect ◽  
Arterial Compliance ◽  
Intervention Group ◽  
Aerobic Exercise Training ◽  
Exercise Induced ◽  
Carotid Arterial ◽  
Regular Intake

Central arterial compliance decreases drastically after menopause. Regular intake of soy isoflavone and aerobic exercise increase arterial compliance. The equol is a metabolite of isoflavone daidzein by gut microbiome. We determined whether the equol producing status affects aerobic exercise-induced improvement in carotid arterial compliance. Forty-three postmenopausal women were assigned to two intervention groups: 1) exercise and isoflavone (Ex + Iso, n=27) or 2) isoflavone interventions (Iso; n=16). Participants of the Ex + Iso intervention group completed an 8-week aerobic exercise training, and all participants were administered with oral isoflavone supplements during the interventions. The equol-producing status (equol producers or non-producers) were determined from urine equol concentrations after a soy challenge. In the Ex + Iso intervention group, carotid arterial compliance increased in the equol producers (0.084±0.030→0.117±0.035 mm2/mmHg) but not in the non-producers (0.089±0.028→0.097±0.026 mm2/mmHg) after the intervention (interaction effect; p<0.05). The magnitude of increases in carotid arterial compliance was significantly greater in the equol producers than in the non-equol producers (p<0.05). In the isoflavone intervention group, there were no changes in any parameters after the intervention irrespective of the equol status. These results suggest that equol-producing status is obligatory to aerobic exercise training-induced improvements in central arterial compliance in postmenopausal women.

Carotid Arterial Compliance and Aerobic Exercise Training in Chronic Traumatic Brain Injury

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Tsubasa Tomoto ◽  
Tran Le ◽  
Takashi Tarumi ◽  
Marisara Dieppa ◽  
Kathleen Bell ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Arterial Compliance ◽  
Aerobic Exercise Training ◽  
Carotid Arterial

Abstract P095: Aerobic Exercise Training Reduces Endothelin-1-mediated Vasoconstriction In Postmenopausal Women

Hypertension ◽  
2020 ◽  
Vol 76 (Suppl_1) ◽  
Author(s):  
Megan M Wenner ◽  
Caitlin Dow ◽  
Jared Greiner ◽  
Brian Stauffer ◽  
Christopher Desouza
Keyword(s):  
Exercise Training ◽  
Aerobic Exercise ◽  
Postmenopausal Women ◽  
Exercise Intervention ◽  
Aerobic Exercise Training ◽  
Receptor Blockade ◽  
Maximal Heart Rate ◽  
Endothelin 1 ◽  
Vasodilator Response ◽  
Exercise Induced

Endothelin-1 (ET-1)-mediated vasoconstrictor tone is elevated in postmenopausal women (PMW), contributing to their increased cardiovascular risk. Although aerobic exercise is beneficial in reducing ET-1 system activity in men, it is unknown whether this favorable vascular effect is conferred in women. In fact, contrary to men, it is uncertain whether aerobic exercise training improves endothelial dysfunction in PMW. We tested the hypothesis that aerobic exercise training reduces ET-1-mediated vasoconstriction in PMW. We further hypothesized reductions in ET-1 vasoconstrictor tone underly exercise-induced improvements in endothelium-dependent vasodilatation in PMW. Methods: Forearm blood flow (FBF) responses to intra-arterial infusion of selective ET A receptor blockade (BQ-123, 100 nmol/min for 60 min), acetylcholine (4.0, 8.0 and 16.0 μg/100 mL tissue/min) in the absence and presence of ET A receptor blockade and sodium nitroprusside (1.0, 2.0 and 4.0 μg/100 mL tissue/min) were determined before and after a 12-week aerobic exercise training intervention in 20 healthy, sedentary PMW (56 + 1 yr). Results: All 20 PMW completed the exercise intervention, walking an average of 4.9 + 0.1 d/wk for 50 + 2 min/d at 71 + 1% of maximal heart rate. After the exercise intervention, BQ-123 elicited no significant change in resting FBF in the previously sedentary PMW compared with significant vasodilation (~25%) before exercise. FBF responses to acetylcholine were markedly higher (~25%; P<0.05) after (from 4.3 + 0.3 to 13.8 + 0.8 mL/100 ml tissue/min) vs before (from 4.1 + 0.2 to 11.3 + 0.8 mL/100 ml tissue/min) exercise training. Moreover, before exercise training the co-infusion of BQ-123 with acetylcholine enhanced (~25%; P<0.05) the vasodilator response (from 4.3 + 0.3 to 13.7 + 0.7 mL/100 mL tissue/min) compared with acetylcholine alone; after exercise training, the presence of BQ-123 did not significantly affect the vasodilator response to acetylcholine. Conclusions: These data demonstrate that aerobic exercise training reduces ET-1-mediated vasoconstriction in PMW. Furthermore, decreased ET-1-mediated vasoconstriction is an important mechanism underlying aerobic exercise-induced improvement in endothelium-dependent vasodilation in PMW.

scholarly journals Differential effect of aerobic exercise training on cardiovagal baroreflex and carotid arterial compliance

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Hidehiko Komine ◽  
Jun Sugawara ◽  
Koichiro Hayashi ◽  
Mutsuko Yoshizawa ◽  
Takashi Yokoi
Keyword(s):  
Exercise Training ◽  
Aerobic Exercise ◽  
Differential Effect ◽  
Arterial Compliance ◽  
Aerobic Exercise Training ◽  
Carotid Arterial

scholarly journals Effect of Low-Intensity Aerobic Exercise Training on Arterial Compliance in Postmenopausal Women

2004 ◽  
Vol 27 (12) ◽  
pp. 897-901 ◽  
Author(s):  
Jun SUGAWARA ◽  
Hironobu INOUE ◽  
Koichiro HAYASHI ◽  
Takashi YOKOI ◽  
Ichiro KONO
Keyword(s):  
Exercise Training ◽  
Aerobic Exercise ◽  
Postmenopausal Women ◽  
Arterial Compliance ◽  
Aerobic Exercise Training ◽  
Low Intensity

scholarly journals Effects of curcumin intake and aerobic exercise training on arterial compliance in postmenopausal women

2012 ◽  
Vol 7 (1) ◽  
pp. 67 ◽  
Author(s):  
Nobuhiko Akazawa ◽  
Youngju Choi ◽  
Asako Miyaki ◽  
Yoko Tanabe ◽  
Jun Sugawara ◽  
...  
Keyword(s):  
Exercise Training ◽  
Aerobic Exercise ◽  
Postmenopausal Women ◽  
Arterial Compliance ◽  
Aerobic Exercise Training

scholarly journals Effects of resveratrol or estradiol on postexercise endothelial function in estrogen-deficient postmenopausal women

2020 ◽  
Vol 128 (4) ◽  
pp. 739-747
Author(s):  
Cemal Ozemek ◽  
Kerry L. Hildreth ◽  
Patrick J. Blatchford ◽  
K. Joseph Hurt ◽  
Rachael Bok ◽  
...  
Keyword(s):  
Exercise Training ◽  
Endothelial Function ◽  
Aerobic Exercise ◽  
Postmenopausal Women ◽  
Endurance Exercise ◽  
Acute Exercise ◽  
Aerobic Exercise Training ◽  
Moderate Intensity ◽  
Training Effects ◽  
Estradiol Treatment

Regular exercise enhances endothelial function in older men, but not consistently in estrogen-deficient postmenopausal women. Estradiol treatment improves basal endothelial function and restores improvements in endothelial function (flow-mediated dilation, FMD) to aerobic exercise training in postmenopausal women; however, estradiol treatment is controversial. Resveratrol, an estrogen receptor ligand, enhances exercise training effects on cardiovascular function and nitric oxide (NO) release in animal models, but impairs exercise training effects in men. We conducted a randomized cross-over, double-blinded, placebo-controlled pilot study to determine whether acute (single dose) resveratrol (250-mg tablet) or estradiol (0.05 mg/day transdermal patch) treatment enhances FMD at rest and after a single bout of moderate-intensity aerobic exercise in healthy estrogen-deficient postmenopausal women ( n = 15, 58.1 ± 3.2 yr). FMD was measured before and after (30, 60, and 120 min) a 40-min bout of moderate-intensity treadmill exercise (60–75% peak heart rate) under the respective conditions (separated by 1-2 wk). FMD was higher ( P < 0.05) before exercise and at all post-exercise time points in the resveratrol and estradiol conditions compared to placebo. FMD was increased from baseline by 120 min postexercise in the estradiol condition ( P < 0.001), but not resveratrol or PL conditions. Consistent with our previous findings, estradiol also enhances endothelial function in response to acute endurance exercise. Although resveratrol improved basal FMD, there was no apparent enhancement of FMD to acute exercise and, therefore, may not act as an estradiol mimetic. NEW & NOTEWORTHY The benefits of endurance exercise training on endothelial function are diminished in estrogen-deficient postmenopausal women, but estradiol treatment appears to restore improvements in endothelial function in this group. We show that basal endothelial function is enhanced with both acute estradiol and resveratrol treatments in estrogen-deficient postmenopausal women, but endothelial function is only enhanced following acute endurance exercise with estradiol treatment.

Aerobic exercise training increases cerebral blood flow in postmenopausal women

2012 ◽  
Vol 6 (3) ◽  
pp. 124 ◽  
Author(s):  
Nobuhiko Akazawa ◽  
Youngju Choi ◽  
Asako Miyaki ◽  
Jun Sugawara ◽  
Ryuichi Ajisaka ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Postmenopausal Women ◽  
Aerobic Exercise Training
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