Intermittent compression induces transitory hypoxic stimuli, upstream vasodilation and enhanced perfusion of skin capillaries, independent of age and diabetes

This study demonstrates that hand intermittent pneumatic compression evokes transitory hypoxic stimuli in distal finger skin microcirculation inducing vasodilation of arterial inflow vessels, enhanced perfusion, and maximum capillary recruitment in young and older subjects and older subjects with type 2 diabetes mellitus. Enhanced shear stress in the microcirculation did not appear to induce local skin vasodilation.

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Resistance-Only Exercise-Induced Changes in Mitochondrial Function in Older Subjects with Type 2 Diabetes Mellitus.

10.1210/endo-meetings.2010.part1.p10.p1-474 ◽

2010 ◽

pp. P1-474-P1-474

Author(s):

PR Hungerford ◽

RL Marcus ◽

O Addison ◽

A Wende ◽

D McClain

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Mitochondrial Function ◽

Older Subjects ◽

Exercise Induced ◽

Induced Changes

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Initial Sulfonylurea Use and Subsequent Insulin Therapy in Older Subjects with Type 2 Diabetes Mellitus

Diabetes Therapy ◽

10.1007/s13300-012-0012-9 ◽

2012 ◽

Vol 3 (1) ◽

Cited By ~ 11

Author(s):

Alex Z. Fu ◽

Ying Qiu ◽

Michael J. Davies ◽

Samuel S. Engel

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Insulin Therapy ◽

Older Subjects

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Effects of Intermittent Pneumatic Compression on Lower Limb Lymphedema in Patients with Type 2 Diabetes Mellitus: A Pilot Randomized Controlled Trial

Medicina ◽

10.3390/medicina57101018 ◽

2021 ◽

Vol 57 (10) ◽

pp. 1018

Author(s):

Alessandro de Sire ◽

Maria Teresa Inzitari ◽

Lucrezia Moggio ◽

Monica Pinto ◽

Giustino de Sire ◽

...

Keyword(s):

Diabetes Mellitus ◽

Outcome Measures ◽

Lower Limb ◽

Controlled Trial ◽

Group Analysis ◽

Intermittent Pneumatic Compression ◽

Control Group ◽

Interstitial Tissue ◽

Experimental Group

Background and Objectives: Diabetes mellitus type 2 (T2DM) is a chronic disease associated with fluid accumulation in the interstitial tissue. Manual lymphatic drainage (MLD) plays a role in reducing lymphoedema, like intermittent pneumatic compression (IPC). By the present pilot study, we aimed to evaluate the efficacy of a synergistic treatment with MLD and IPC in reducing lower limb lymphedema in T2DM patients. Materials and Methods: Adults with a clinical diagnosis of T2DM and lower limb lymphedema (stage II–IV) were recruited from July to December 2020. Study participants were randomized into two groups: experimental group, undergoing a 1-month rehabilitative program consisting of MLD and IPC (with a compression of 60 to 80 mmHg); control group, undergoing MLD and a sham IPC (with compression of <30 mmHg). The primary outcome was the lower limb lymphedema reduction, assessed by the circumferential method (CM). Secondary outcomes were: passive range of motion (pROM) of hip, knee, and ankle; quality of life; laboratory exams as fasting plasma glucose and HbA1c. At baseline (T0) and at the end of the 1-month rehabilitative treatment (T1), all the outcome measures were assessed, except for the Hb1Ac evaluated after three months. Results: Out of 66 T2DM patients recruited, only 30 respected the eligibility criteria and were randomly allocated into 2 groups: experimental group (n = 15; mean age: 54.2 ± 4.9 years) and control group (n = 15; mean age: 54.0 ± 5.5 years). At the intra-group analysis, the experimental group showed a statistically significant improvement of all outcome measures (p < 0.05). The between-group analysis showed a statistically significant improvement in pROM of the hip, knee, ankle, EQ-VAS, and EQ5D3L index at T1. Conclusions: A multimodal approach consisting of IPC and MLD showed to play a role in reducing lower limb lymphedema, with an increase of pROM and HRQoL. Since these are preliminary data, further studies are needed.

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