High Gamma Activity in Response to Deviant Auditory Stimuli Recorded Directly From Human Cortex

2005 ◽  
Vol 94 (6) ◽  
pp. 4269-4280 ◽  
Author(s):  
Erik Edwards ◽  
Maryam Soltani ◽  
Leon Y. Deouell ◽  
Mitchel S. Berger ◽  
Robert T. Knight
Keyword(s):  
Temporal Lobe ◽  
Temporal Cortex ◽  
Event Related Potentials ◽  
Gamma Oscillations ◽  
Auditory Stimuli ◽  
Association Cortex ◽  
Neurosurgical Patients ◽  
High Gamma ◽  
Related Potentials ◽  
Auditory Association Cortex

We recorded electrophysiological responses from the left frontal and temporal cortex of awake neurosurgical patients to both repetitive background and rare deviant auditory stimuli. Prominent sensory event-related potentials (ERPs) were recorded from auditory association cortex of the temporal lobe and adjacent regions surrounding the posterior Sylvian fissure. Deviant stimuli generated an additional longer latency mismatch response, maximal at more anterior temporal lobe sites. We found low gamma (30–60 Hz) in auditory association cortex, and we also show the existence of high-frequency oscillations above the traditional gamma range (high gamma, 60–250 Hz). Sensory and mismatch potentials were not reliably observed at frontal recording sites. We suggest that the high gamma oscillations are sensory-induced neocortical ripples, similar in physiological origin to the well-studied ripples of the hippocampus.

scholarly journals Cholinergic Mechanisms of Target Oddball Stimuli Detection: The Late “P300-Like” Event-Related Potential in Rats

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
A. Ahnaou ◽  
R. Biermans ◽  
W. H. I. M. Drinkenburg
Keyword(s):  
Auditory Evoked Potentials ◽  
Event Related Potentials ◽  
Gamma Oscillations ◽  
Synaptic Function ◽  
Event Related Potential ◽  
Peak Amplitude ◽  
Auditory Stimuli ◽  
Disruptive Effect ◽  
Pharmacological Agents ◽  
Related Potentials

Event-related potentials (ERPs) and oscillations (EROs) provide powerful tools for studying the brain’s synaptic function underlying information processing. The P300 component of ERPs indexing attention and working memory shows abnormal amplitude and latency in neurological and psychiatric diseases that are sensitive to pharmacological agents. In the active auditory oddball discriminant paradigm, behavior and auditory-evoked potentials (AEPs) were simultaneously recorded in awake rats to investigate whether P300-like potentials generated in rats responding to rare target oddball tones are sensitive to subcutaneous modulation of the cholinergic tone by donepezil (1 mg/kg) and scopolamine (0.64 mg/kg). After operant training, rats consistently discriminate rare target auditory stimuli from frequent irrelevant nontarget auditory stimuli by a higher level of correct lever presses (i.e., accuracy) in target trials associated with a food reward. Donepezil attenuated the disruptive effect of scopolamine on the level of accuracy and premature responses in target trials. Larger P300-like peaks with early and late components were revealed in correct rare target stimuli trials as compared to frequent tones. Donepezil enhanced the peak amplitude of the P300-like component to target stimuli and evoked slow theta and gamma oscillations, whereas scopolamine altered the amplitude of the P300-like component and EROs to target stimuli. Pretreatment with donepezil attenuated effects of scopolamine on the peak amplitude of the P300-like component and on EROs. This study provides evidence that AEP P300-like responses can be elicited by rats engaged in attentive and memory processing of target stimuli and outline the relevance of the cholinergic system in stimulus discrimination processing. The findings highlight the sensitivity of this translational index for investigating brain circuits and/or novel pharmacological agents, which modulate cholinergic transmission associated with increased allocation of attentional resources.

Scalp-Recorded Auditory P300 Event-Related Potentials in New-Onset Untreated Temporal Lobe Epilepsy

2007 ◽  
Vol 38 (3) ◽  
pp. 168-171 ◽  
Author(s):  
Wuttichai V. Chayasirisobhon ◽  
Sirichai Chayasirisobhon ◽  
Sue Nwe Tin ◽  
Ngoc Leu ◽  
Keo Tehrani ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Hippocampal Sclerosis ◽  
Event Related Potentials ◽  
Auditory Event ◽  
Auditory P300 ◽  
Related Potentials ◽  
Auditory Erps ◽  
Auditory Event Related Potentials ◽  
New Onset

We studied scalp-recorded auditory event-related potentials (ERPs) of 30 untreated patients with new-onset temporal lobe epilepsy and 30 age-and sex-matched normal controls. This study was designed to eliminate the effects of intractability of seizures and chronic use of antiepileptic drugs on P300 auditory ERPs. There were no statistically significant differences in both latency and amplitude of P300 between the two groups. Similar methods were also used to analyze component latencies and amplitudes of ERPs of 9 patients who had hippocampal sclerosis with comparison to control subjects. There were no statistically significant differences between these two groups as well. Our study evidently does not support temporal lobe sources of P300 scalp-recorded auditory ERPs. We also conclude that the scalp-recorded auditory ERPs procedure is not a useful tool to evaluate temporal lobe epilepsy.

Event-related potentials to auditory stimuli in female Vietnam nurse veterans with posttraumatic stress disorder

2002 ◽  
Vol 39 (1) ◽  
pp. 49-63 ◽  
Author(s):  
Linda J. Metzger ◽  
Margaret A. Carson ◽  
Lynn A. Paulus ◽  
Natasha B. Lasko ◽  
Stephen R. Paige ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Event Related Potentials ◽  
Auditory Stimuli ◽  
Related Potentials

scholarly journals A Basic Study on P300 Event-Related Potentials Evoked by Simultaneous Presentation of Visual and Auditory Stimuli for the Communication Interface

i-Perception ◽  
10.1068/ic785 ◽  
2011 ◽  
Vol 2 (8) ◽  
pp. 785-785
Author(s):  
Masami Hashimoto ◽  
Makoto Chishima ◽  
Kazunori Itoh ◽  
Mizue Kayama ◽  
Makoto Otani ◽  
...  
Keyword(s):  
Event Related Potentials ◽  
Simultaneous Presentation ◽  
Auditory Stimuli ◽  
Communication Interface ◽  
Basic Study ◽  
Related Potentials

The role of attention in auditory information processing as revealed by event-related potentials and other brain measures of cognitive function

1990 ◽  
Vol 13 (2) ◽  
pp. 201-233 ◽  
Author(s):  
Risto Näätänen
Keyword(s):  
Semantic Processing ◽  
Event Related Potentials ◽  
Event Related Potential ◽  
Auditory Stimuli ◽  
Stimulus Selection ◽  
Auditory Information ◽  
Attention Switching ◽  
Related Potentials ◽  
Physical Features

AbstractThis article examines the role of attention and automaticity in auditory processing as revealed by event-related potential (ERP) research. An ERP component called the mismatch negativity, generated by the brain's automatic response to changes in repetitive auditory input, reveals that physical features of auditory stimuli are fully processed whether or not they are attended. It also suggests that there exist precise neuronal representations of the physical features of recent auditory stimuli, perhaps the traces underlying acoustic sensory (“echoic”) memory. A mechanism of passive attention switching in response to changes in repetitive input is also implicated.Conscious perception of discrete acoustic stimuli might be mediated by some of the mechanisms underlying another ERP component (NI), one sensitive to stimulus onset and offset. Frequent passive attentional shifts might accountforthe effect cognitive psychologists describe as “the breakthrough of the unattended” (Broadbent 1982), that is, that even unattended stimuli may be semantically processed, without assuming automatic semantic processing or late selection in selective attention.The processing negativity supports the early-selection theory and may arise from a mechanism for selectively attending to stimuli defined by certain features. This stimulus selection occurs in the form ofa matching process in which each input is compared with the “attentional trace,” a voluntarily maintained representation of the task-relevant features of the stimulus to be attended. The attentional mechanism described might underlie the stimulus-set mode of attention proposed by Broadbent. Finally, a model of automatic and attentional processing in audition is proposed that is based mainly on the aforementioned ERP components and some other physiological measures.

Processing of famous faces and medial temporal lobe event-related potentials: a depth electrode study

NeuroImage ◽  
2005 ◽  
Vol 25 (2) ◽  
pp. 401-407 ◽  
Author(s):  
T. Dietl ◽  
P. Trautner ◽  
M. Staedtgen ◽  
M. Vannuchi ◽  
A. Mecklinger ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Event Related Potentials ◽  
Depth Electrode ◽  
Related Potentials
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