Mechanisms of severe acute intermittent hypoxia-induced phrenic long-term facilitation
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Distinct mechanisms give rise to pLTF induced by moderate and severe AIH. We demonstrate that, unlike moderate AIH, severe AIH-induced pLTF requires EPAC and PI3K/Akt and is marginally constrained by NADPH oxidase activity. Surprisingly, sAIH-induced pLTF requires MEK/ERK activity similar to moderate AIH-induced pLTF and is reduced by PKA inhibition. We suggest sAIH-induced pLTF arises from complex interactions between dominant mechanisms characteristic of moderate versus severe AIH-induced pLTF.
2009 ◽
Vol 587
(9)
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pp. 1931-1942
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Keyword(s):
2018 ◽
Vol 141
(2)
◽
pp. AB197
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