scholarly journals Long-range GABAergic neurons in the prefrontal cortex modulate behavior

2015 ◽  
Vol 114 (3) ◽  
pp. 1357-1359 ◽  
Author(s):  
Christian Bravo-Rivera ◽  
Maria M. Diehl ◽  
Ciorana Roman-Ortiz ◽  
Jose Rodriguez-Romaguera ◽  
Luis E. Rosas-Vidal ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Learning And Memory ◽  
Long Range ◽  
Medial Prefrontal Cortex ◽  
Behavioral Neuroscience ◽  
Memory Models ◽  
Gabaergic Neurons

Cortical glutamatergic projections are extensively studied in behavioral neuroscience, whereas cortical GABAergic projections to downstream structures have been overlooked. A recent study by Lee and colleagues (Lee AT, Vogt D, Rubenstein JL, Sohal VS. J Neurosci 34: 11519–11525, 2014) used optogenetic and electrophysiological techniques to characterize a behavioral role for long-projecting GABAergic neurons in the medial prefrontal cortex. In this Neuro Forum, we discuss the potential implications of this study in several learning and memory models.

A whole-brain map of long-range inputs to GABAergic interneurons in the mouse medial prefrontal cortex

2019 ◽  
Vol 22 (8) ◽  
pp. 1357-1370 ◽  
Author(s):  
Qingtao Sun ◽  
Xiangning Li ◽  
Miao Ren ◽  
Mengting Zhao ◽  
Qiuyuan Zhong ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Long Range ◽  
Medial Prefrontal Cortex ◽  
Gabaergic Interneurons ◽  
Whole Brain

scholarly journals Theta oscillations in the prefrontal-hippocampal circuit do not couple to respiration-related oscillations

2021 ◽  
Author(s):  
Sunandha Srikanth ◽  
Dylan Le ◽  
Yudi Hu ◽  
Jill K Leutgeb ◽  
Stefan Leutgeb
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Learning And Memory ◽  
Long Range ◽  
Brain Regions ◽  
Theta Oscillations ◽  
Oscillatory Activity ◽  
Low Coherence ◽  
Theta Frequency ◽  
Neural Computations

Oscillatory activity is thought to coordinate neural computations across brain regions, and theta oscillations are critical for learning and memory. Because the frequency of respiratory-related oscillations (RROs) in rodents can overlap with the frequency of theta in the prefrontal cortex (PFC) and the hippocampus, we asked whether odor-cued working memory may be supported by coupling between these two oscillations. We first confirmed that RROs are propagated to the hippocampus and PFC and that RRO frequency overlaps with canonical theta frequency. However, we found low coherence between RROs and local theta oscillations in the hippocampus-PFC network when the two types of oscillations overlapped in frequency. This effect was observed during all behavioral phases including during movement and while odors were actively sampled when stationary. Despite the similarity in frequency, RROs and theta oscillations therefore appear to be limited to supporting computation in distinct networks, which suggests that sustained long-range coordination between oscillation patterns that depend on separate pacemakers is not necessary to support at least one type of working memory.

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