scholarly journals Rat models of 17β-estradiol-induced mammary cancer reveal novel insights into breast cancer etiology and prevention

2018 ◽  
Vol 50 (3) ◽  
pp. 215-234 ◽  
Author(s):  
James D. Shull ◽  
Kirsten L. Dennison ◽  
Aaron C. Chack ◽  
Amy Trentham-Dietz
Keyword(s):  
Breast Cancer ◽  
Mammary Cancer ◽  
Dietary Factors ◽  
Cancer Development ◽  
Research Progress ◽  
Cancer Etiology ◽  
Rat Models ◽  
Cancer Data ◽  
Breast Cancer Etiology ◽  
17Β Estradiol

Numerous laboratory and epidemiologic studies strongly implicate endogenous and exogenous estrogens in the etiology of breast cancer. Data summarized herein suggest that the ACI rat model of 17β-estradiol (E2)-induced mammary cancer is unique among rodent models in the extent to which it faithfully reflects the etiology and biology of luminal types of breast cancer, which together constitute ~70% of all breast cancers. E2 drives cancer development in this model through mechanisms that are largely dependent upon estrogen receptors and require progesterone and its receptors. Moreover, mammary cancer development appears to be associated with generation of oxidative stress and can be modified by multiple dietary factors, several of which may attenuate the actions of reactive oxygen species. Studies of susceptible ACI rats and resistant COP or BN rats provide novel insights into the genetic bases of susceptibility and the biological processes regulated by genetic determinants of susceptibility. This review summarizes research progress resulting from use of these physiologically relevant rat models to advance understanding of breast cancer etiology and prevention.

scholarly journals Development and characterization of a novel rat model of estrogen-induced mammary cancer

2015 ◽  
Vol 22 (2) ◽  
pp. 239-248 ◽  
Author(s):  
Kirsten L Dennison ◽  
Nyssa Becker Samanas ◽  
Quincy Eckert Harenda ◽  
Maureen Peters Hickman ◽  
Nicole L Seiler ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Rat Model ◽  
Mammary Cancer ◽  
Pituitary Tumors ◽  
Cancer Etiology ◽  
Breast Cancer Etiology ◽  
Rat Strain ◽  
Inbred Rat ◽  
High Degree ◽  
Pituitary Lactotroph

The ACI rat model of 17β-estradiol (E2)-induced mammary cancer is highly relevant for use in establishing the endocrine, genetic, and environmental bases of breast cancer etiology and identifying novel agents and strategies for preventing breast cancer. E2 treatment rapidly induces mammary cancer in female ACI rats and simultaneously induces pituitary lactotroph hyperplasia and adenoma. The pituitary tumors can result in undesired morbidity, which compromises long-term studies focused on mammary cancer etiology and prevention. We have defined the genetic bases of susceptibility to E2-induced mammary cancers and pituitary tumors and have utilized the knowledge gained in these studies to develop a novel inbred rat strain, designated ACWi, that retains the high degree of susceptibility to E2-induced mammary cancer exhibited by ACI rats, but lacks the treatment-related morbidity associated with pituitary lactotroph hyperplasia/adenoma. When treated with E2, female ACWi rats developed palpable mammary cancer at a median latency of 116 days, an incidence of 100% by 161 days and exhibited an average of 15.6 mammary tumors per rat following 196 days of treatment. These parameters did not differ from those observed for contemporaneously treated ACI rats. None of the E2-treated ACWi rats were killed before the intended experimental end point due to any treatment-related morbidity other than mammary cancer burden, whereas 20% of contemporaneously treated ACI rats exhibited treatment-related morbidity that necessitated premature killing. The ACWi rat strain is well suited for use by those in the research community, focusing on breast cancer etiology and prevention.

Chapter II. Breast-Cancer Etiology

1990 ◽  
Vol 46 (S5) ◽  
pp. 22-39
Author(s):  
Adami Hans-Olov ◽  
Adams Gerald ◽  
Boyle Peter ◽  
Ewertz Marianne ◽  
C. Lee Nancy ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Etiology ◽  
Breast Cancer Etiology

Does a Bite Cause Cancer? Misperceptions of Breast Cancer Etiology among Low-Income Urban Women in Miami, Florida

2013 ◽  
Vol 106 (12) ◽  
pp. 649-654 ◽  
Author(s):  
Erin N. Marcus ◽  
Darlene K. Drummond ◽  
Noella Dietz ◽  
Sonjia Kenya
Keyword(s):  
Breast Cancer ◽  
Low Income ◽  
Urban Women ◽  
Cancer Etiology ◽  
Breast Cancer Etiology

Abstract 805: The molecular mechanisms of obesity driving breast cancer etiology and prognosis in post-menopausal women

2016 ◽  
Author(s):  
Yu Jing Jan Heng ◽  
Jun Wang ◽  
Aditi Hazra ◽  
David J. Hunter ◽  
A. Heather Eliassen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Molecular Mechanisms ◽  
Cancer Etiology ◽  
Breast Cancer Etiology ◽  
Menopausal Women ◽  
Post Menopausal

scholarly journals Breast Cancer Prevention-Is there a Future for Sulforaphane and Its Analogs?

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1559
Author(s):  
Dominika Kuran ◽  
Anna Pogorzelska ◽  
Katarzyna Wiktorska
Keyword(s):  
Breast Cancer ◽  
Cancer Prevention ◽  
Initial Study ◽  
Dietary Factors ◽  
Breast Cancer Prevention ◽  
In Vivo Studies ◽  
Cancer Etiology ◽  
The Impact

Breast cancer is the most prevalent type of cancer among women worldwide. There are several recommended methods of breast cancer prevention, including chemoprevention. There are several approved drugs used to prevent breast cancer occurrence or recurrence and metastasizing. There are also a number of new substances undergoing clinical trials and at the stage of initial study. Studies suggest that dietary factors play a crucial role in breast cancer etiology. Epidemiological studies indicate that in particular vegetables from the Brassicaceae family are a rich source of chemopreventive substances, with sulforaphane (SFN) being one of the most widely studied and characterized. This review discusses potential applicability of SFN in breast cancer chemoprevention. A comprehensive review of the literature on the impact of SFN on molecular signalling pathways in breast cancer and breast untransformed cells is presented. The presented results of in vitro and in vivo studies show that this molecule has a potential to act as a preventive molecule either to prevent disease development or recurrence and metastasizing, and as a compound protecting normal cells against the toxic effects of cytostatics. Finally, the still scanty attempts to develop an improved analog are also presented and discussed.

scholarly journals PULMONARY EMBOLISM IN BREAST CANCER: ETIOLOGY, PATHOPHYSIOLOGY AND TREATMENT APPROACHES

2016 ◽  
Vol 44 (5) ◽  
pp. 580-586
Author(s):  
I. D. Rozanov ◽  
E. A. Rozanova ◽  
E. I. Shirikov ◽  
A. S. Balkanov ◽  
L. E. Gaganov ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Pulmonary Embolism ◽  
Cancer Etiology ◽  
Treatment Approaches ◽  
Breast Cancer Etiology
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