scholarly journals Oxidative Stress in Chronic Hepatitis C: The Effect of Interferon Therapy and Correlation with Pathological Features

2003 ◽  
Vol 17 (11) ◽  
pp. 644-650 ◽  
Author(s):  
Fátima Serejo ◽  
Ingrid Emerit ◽  
Paulo Manuel Filipe ◽  
Afonso Camilo Fernandes ◽  
Maria Adília Costa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
G Protein ◽  
Chronic Hepatitis C ◽  
Protein A ◽  
Chromosomal Breakage ◽  
Amino Terminal ◽  
Fibrosis Staging

AIMS: To evaluate the oxidative stress parameters before, during and after interferon treatment.PATIENTS/METHODS: Twenty patients were treated with interferon α2b 5 MU, three times a week, subcutaneously, for 12 months. Liver biopsy was performed six months before treatment and at the six month follow-up. Chromosomal breakage studies were evaluated by the adjusted clastogenic score (ACS, normal value [nv] 1.1±2.4%). Plasma malondialdehyde (MDA) was measured according to the Yagi method (nv 6.6±1.4 nmol/mL) and total thiols using the Ellman’s reagent (DTNB) (nv 9.8±1.3 µmol/g protein). A serum marker of fibrogenesis, the amino-terminal propeptide of Procollagen type III (PIIIP), was quantified by radioimmunoassay (nv 0.37±0.18 U/L).RESULTS: Compared with reference samples, the plasma of patients before treatment showed an increase of ACS (9.2±3.2%, P<0.001); higher MDA values (12.6±2.7nmol/mL, P<0.001) and total plasma sulfhydryl groups (t-SH) were decreased (6.3±1.1 µmol/g protein, P<0.001). During treatment and at the follow-up, a decrease in ACS was noticed in all patients (P<0.001), but without normalization; a decrease in MDA was seen, with progressive normalization until the end of the follow up only in sustained responders (P<0.003), while an increase of t-SH was seen, with progressive normalization until the end of follow up in all patients (P<0.005). A positive correlation of ACS with grading of inflammation was found (r=0.52, P<0.03) but not with fibrosis staging. In contrast, plasma MDA correlates with fibrosis staging (r=0.51, P<0.03) and with PIIIP (r=0.57, P<0.03) but without grading of inflammation.CONCLUSIONS: The present study confirmed the presence of oxidative stress in chronic hepatitis C patients. Interferon promotes a long term inhibition of oxidative stress with concomitant improvement of activity and fibrosis. In the management of chronic hepatitis C, adjuvant therapy with antioxidants could be useful.

scholarly journals Follow-up of patients with chronic hepatitis C and a sustained viral response

2016 ◽  
Vol 36 ◽  
pp. 67-71 ◽  
Author(s):  
Lawrence Serfaty
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Sustained Viral Response ◽  
Viral Response

scholarly journals A Six‐Year Follow‐Up After Interferon‐Alpha Monotherapy for Chronic Hepatitis C Infection in Hemodialysis Patients

Renal Failure ◽  
2004 ◽  
Vol 26 (5) ◽  
pp. 583-588 ◽  
Author(s):  
Fatma Nurhan Ozdemir ◽  
Ali Akcay ◽  
Siren Sezer ◽  
Sedat Boyacioglu ◽  
Binnaz Handan Ozdemir ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Interferon Alpha ◽  
Hemodialysis Patients ◽  
Hepatitis C Infection

scholarly journals CPC-107 Pharmacotherapy Follow-Up in Chronic Hepatitis C Patients Treated with Boceprevir or Telaprevir

2013 ◽  
Vol 20 (Suppl 1) ◽  
pp. A203.2-A203
Author(s):  
I Cañamares-Orbis ◽  
C García-Muñoz ◽  
M Campo-Angora ◽  
JM Ferrari-Piquero ◽  
I Escribano-Valenciano
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Chronic Hepatitis C Patients

Effectiveness of Sofosbuvir and Velpatasvir Combination in Chronic Hepatitis C with Hemodialysis Patients

2021 ◽  
Vol 15 (5) ◽  
pp. 1205-1207
Author(s):  
R. A. Khan ◽  
A. Ali ◽  
S. Munib ◽  
I. Muhammad ◽  
NOSHER WAN ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Prospective Observational Study ◽  
Hemodialysis Patients ◽  
Hemoglobin Level ◽  
Adverse Outcomes ◽  
Keywords Hemodialysis

Objective: The aim of this study is to determine the response of sofosbuvir and velpatasvir combination in chronic hepatitis C with hemodialysis patients. Study Design: Prospective/observational study Place and Duration: The study was conducted at department of Nephrology Nawaz Sharif Kidney Hospital, Swat for duration of six months from 1st July to 31st December, 2020. Methods: Total 27 patients of both genders were presented in this study. Patients were aged between 18-85 years. Patients details demographics age, sex and body mass index were recorded after taking written consent. Patients diagnosis hepatitis C with recognized genotypes were presented. Enrolled patients received combination of sofosbuvir and velpatasvir regime (SOF/VLP) for 14 weeks and follow up was taken. Effectiveness and safety among HCV patients on hemodialysis were observed. Complete data was analyzed by SPSS 22.0 version. Results: Out of 27 patients 17 (62.96%) were males 10 (37.04%) were females. Mean age of the patients was 35.14±5.18 years with mean BMI 24.41±6.25 kg/m2. Hypertension was the most common comorbidity found in 15 (55.55%) patients followed by obesity 8 (29.63%) and diabetes found in 3 (14.81%). Among 27 cases 20 (74.04%) were naïve and 7 (25.96%) were treatment experienced. Sustained virological response was found in 26 (96.3%) and 1(3.7%) patients were lost at follow up. Significantly improvement was found in hemoglobin level 12.11 ± 5.24, alanine aminotransferase (ALT) 28.51 ± 9.62 and aspartate aminotransferase (AST) 35.24 ± 7.08 after treatment. Headache, fatigue and nausea were the most common adverse outcomes. Conclusion: We concluded in this study that the use of sofosbuvir and velpatasvir was effective safe and well tolerated in the treatment of hepatitis C patients with hemodialysis. Keywords: Hemodialysis, Hepatitis C, Sofosbuvir, Velpatasvir, Complications

Oxidative stress in chronic hepatitis C: not just a feature of late stage disease

2002 ◽  
Vol 36 (6) ◽  
pp. 805-811 ◽  
Author(s):  
Sanjiv K. Jain ◽  
Philip W. Pemberton ◽  
Alexander Smith ◽  
Raymond F.T. McMahon ◽  
Peter C. Burrows ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Late Stage ◽  
Stage Disease ◽  
Late Stage Disease

Simplified follow-up of patients with mild chronic hepatitis C in areas with limited access to antiviral therapy

2019 ◽  
Vol 51 (6) ◽  
pp. 875-881
Author(s):  
Sabela Lens ◽  
Ferran Torres ◽  
Martin Bonacci ◽  
Concepció Bartres ◽  
Anna Pocurull ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Antiviral Therapy ◽  
Chronic Hepatitis C ◽  
Limited Access

scholarly journals Hepatitis C elimination in the Netherlands (CELINE): study protocol for nationwide retrieval of lost to follow-up patients with chronic hepatitis C

2020 ◽  
Vol 7 (1) ◽  
pp. e000396 ◽  
Author(s):  
Cas J Isfordink ◽  
Sylvia M Brakenhoff ◽  
Marleen van Dijk ◽  
Marc van der Valk ◽  
Rob J de Knegt ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
The Netherlands ◽  
Chronic Hepatitis C ◽  
Hcv Rna ◽  
Ethical Approval ◽  
Hcv Transmission ◽  
Chronic Hcv ◽  
Lost To Follow Up

BackgroundThe Netherlands has a low hepatitis C virus (HCV) prevalence, estimated at 0.16%. Previous studies have shown that up to 30% of the diagnosed HCV population in the Netherlands has been lost to follow-up (LTFU). Retrieval of these patients could halt progression of liver disease in infected patients, reduce the number of infected individuals and limit HCV transmission. Several regional Dutch retrieval projects have already been executed, which demonstrated that retrieval is feasible. Therefore, we initiated a nationwide retrieval project, aiming to achieve microelimination in previously diagnosed but LTFU patients with chronic HCV through retrieval.MethodsLaboratory records will be used to identify possible patients with chronic hepatitis C, defined as either a positive most recent HCV RNA or positive HCV antibodies without known RNA result. Reviewing patient records and obtaining current contact information from municipality databases will identify LTFU patients who are eligible for retrieval. These patients will be invited for outpatient clinic care. The primary outcome of the study is the total number of LTFU patients who have been successfully linked to care.DiscussionHepatitis C ELimination In the NEtherlands (CELINE) is within the remit of WHO elimination targets and the Dutch National Hepatitis Plan. The methodology of CELINE is based on previously conducted regional retrieval projects and is designed to overcome some of their limitations. After ethical approval was obtained in 2018, the first centre initiated retrieval in 2018 and the project is expected to finish in 2021.Trial registration numberNCT04208035.

Long-Term Follow-Up of Patients with Chronic Hepatitis C after Interferon-Alpha Treatment

Digestion ◽  
1996 ◽  
Vol 57 (6) ◽  
pp. 464-471 ◽  
Author(s):  
Gerlinde Teuber ◽  
Hans-Peter Dienes ◽  
Karl-Hermann Meyer zum Büschenfelde ◽  
Guido Gerken
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Interferon Alpha ◽  
Long Term Follow Up ◽  
Interferon Alpha Treatment
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