Oxidative stress in chronic hepatitis C: not just a feature of late stage disease

2002 ◽  
Vol 36 (6) ◽  
pp. 805-811 ◽  
Author(s):  
Sanjiv K. Jain ◽  
Philip W. Pemberton ◽  
Alexander Smith ◽  
Raymond F.T. McMahon ◽  
Peter C. Burrows ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Late Stage ◽  
Stage Disease ◽  
Late Stage Disease

scholarly journals Viral load and oxidative stress in Egyptian chronic hepatitis C patients

2016 ◽  
Vol 53 ◽  
pp. 106-107
Author(s):  
B.A.M. El Awady ◽  
B. Hussein ◽  
E. El-Seidi ◽  
Y. Abou-Hamed
Keyword(s):  
Oxidative Stress ◽  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Chronic Hepatitis C Patients ◽  
And Oxidative Stress

Catalase gene rs1001179 polymorphism and oxidative stress in patients with chronic hepatitis C and ulcerative colitis

2015 ◽  
Vol 87 (2) ◽  
pp. 49 ◽  
Author(s):  
I. A. Bulatova ◽  
Yu. I. Tretyakova ◽  
V. V. Shchekotov ◽  
A. P. Shchekotova ◽  
P. V. Ulitina ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ulcerative Colitis ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Catalase Gene ◽  
And Oxidative Stress

Immunohistochemical Evaluation of Oxidative Stress Markers in Chronic Hepatitis C

2004 ◽  
Vol 6 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Sabina Mahmood ◽  
Miwa Kawanaka ◽  
Ayumi Kamei ◽  
Akiyoshi Izumi ◽  
Keiichi Nakata ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Oxidative Stress Markers ◽  
Stress Markers

The effect of increased oxidative stress and ferritin in reducing the effectiveness of therapy in chronic hepatitis C patients

2012 ◽  
Vol 45 (16-17) ◽  
pp. 1389-1393 ◽  
Author(s):  
Ya-Lin Chiou ◽  
Yi-Hui Chen ◽  
Tiffany Ke ◽  
Wang-Sheng Ko
Keyword(s):  
Oxidative Stress ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Chronic Hepatitis C Patients

scholarly journals Decreased Total Antioxidant Capacity and Increased Oxidative Stress and Serum Ferritin Levels in Untreated Chronic Hepatitis C Patients

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Isaias Dichi ◽  
Danielle Venturini ◽  
Andrea Colado Simão ◽  
Décio Sabbatini Barbosa ◽  
Edson Lopes Lavado ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Antioxidant Capacity ◽  
Chronic Hepatitis C ◽  
Serum Ferritin ◽  
Total Antioxidant Capacity ◽  
Total Antioxidant ◽  
Chronic Hepatitis C Patients

Insulin resistance and not steatosis is associated with modifications in oxidative stress markers in chronic hepatitis C, non-3 genotype

2009 ◽  
pp. 1-8
Author(s):  
Ana Oliveira ◽  
Edison Parise ◽  
Regina Catarino ◽  
Valeria Lanzoni ◽  
Mariliza Leite-Mor ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Oxidative Stress Markers ◽  
Stress Markers

scholarly journals Oxidative Stress in Chronic Hepatitis C: The Effect of Interferon Therapy and Correlation with Pathological Features

2003 ◽  
Vol 17 (11) ◽  
pp. 644-650 ◽  
Author(s):  
Fátima Serejo ◽  
Ingrid Emerit ◽  
Paulo Manuel Filipe ◽  
Afonso Camilo Fernandes ◽  
Maria Adília Costa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
G Protein ◽  
Chronic Hepatitis C ◽  
Protein A ◽  
Chromosomal Breakage ◽  
Amino Terminal ◽  
Fibrosis Staging

AIMS: To evaluate the oxidative stress parameters before, during and after interferon treatment.PATIENTS/METHODS: Twenty patients were treated with interferon α2b 5 MU, three times a week, subcutaneously, for 12 months. Liver biopsy was performed six months before treatment and at the six month follow-up. Chromosomal breakage studies were evaluated by the adjusted clastogenic score (ACS, normal value [nv] 1.1±2.4%). Plasma malondialdehyde (MDA) was measured according to the Yagi method (nv 6.6±1.4 nmol/mL) and total thiols using the Ellman’s reagent (DTNB) (nv 9.8±1.3 µmol/g protein). A serum marker of fibrogenesis, the amino-terminal propeptide of Procollagen type III (PIIIP), was quantified by radioimmunoassay (nv 0.37±0.18 U/L).RESULTS: Compared with reference samples, the plasma of patients before treatment showed an increase of ACS (9.2±3.2%, P<0.001); higher MDA values (12.6±2.7nmol/mL, P<0.001) and total plasma sulfhydryl groups (t-SH) were decreased (6.3±1.1 µmol/g protein, P<0.001). During treatment and at the follow-up, a decrease in ACS was noticed in all patients (P<0.001), but without normalization; a decrease in MDA was seen, with progressive normalization until the end of the follow up only in sustained responders (P<0.003), while an increase of t-SH was seen, with progressive normalization until the end of follow up in all patients (P<0.005). A positive correlation of ACS with grading of inflammation was found (r=0.52, P<0.03) but not with fibrosis staging. In contrast, plasma MDA correlates with fibrosis staging (r=0.51, P<0.03) and with PIIIP (r=0.57, P<0.03) but without grading of inflammation.CONCLUSIONS: The present study confirmed the presence of oxidative stress in chronic hepatitis C patients. Interferon promotes a long term inhibition of oxidative stress with concomitant improvement of activity and fibrosis. In the management of chronic hepatitis C, adjuvant therapy with antioxidants could be useful.

Profile of oxidative stress markers is dependent on vitamin D levels in patients with chronic hepatitis C

Nutrition ◽  
2016 ◽  
Vol 32 (3) ◽  
pp. 362-367 ◽  
Author(s):  
Jorge P. Sales de Almeida ◽  
Lucas Silva Liberatti ◽  
Fernanda Esteves Nascimento Barros ◽  
Ana Paula Kallaur ◽  
Marcell A. Batisti Lozovoy ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Vitamin D Levels
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