scholarly journals Asbestos and Probable Microscopic Polyangiitis

2004 ◽  
Vol 11 (5) ◽  
pp. 359-362 ◽  
Author(s):  
George S Rashed Philteos ◽  
Kelly Coverett ◽  
Rajni Chibbar ◽  
Heather A Ward ◽  
Donald W Cockcroft
Keyword(s):  
Autoimmune Diseases ◽  
Lung Diseases ◽  
Microscopic Polyangiitis ◽  
Present Report ◽  
Vascular Diseases ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Collagen Vascular Diseases ◽  
Immunological Mechanisms ◽  
Pulmonary Asbestosis

Several inorganic dust lung diseases (pneumoconioses) are associated with autoimmune diseases. Although autoimmune serological abnormalities are common in asbestosis, clinical autoimmune/collagen vascular diseases are not commonly reported. A case of pulmonary asbestosis complicated by perinuclear-antineutrophil cytoplasmic antibody (myeloperoxidase) positive probable microscopic polyangiitis (glomerulonephritis, pericarditis, alveolitis, multineuritis multiplex) is described and the possible immunological mechanisms whereby asbestosis fibres might be relevant in induction of antineutrophil cytoplasmic antibodies are reviewed in the present report.

Interstitial Lung Diseases Associated with Collagen Vascular Diseases: Radiologic and Histopathologic Findings

Radiographics ◽  
2002 ◽  
Vol 22 (suppl_1) ◽  
pp. S151-S165 ◽  
Author(s):  
Eun A Kim ◽  
Kyung Soo Lee ◽  
Takeshi Johkoh ◽  
Tae Sung Kim ◽  
Gee Young Suh ◽  
...  
Keyword(s):  
Lung Diseases ◽  
Vascular Diseases ◽  
Interstitial Lung Diseases ◽  
Collagen Vascular Diseases ◽  
Histopathologic Findings

scholarly journals Antineutrophil Cytoplasmic Antibody–associated Glomerulonephritis Complicated by Pneumatosis Intestinalis

2015 ◽  
Vol 8 ◽  
pp. CCRep.S26155 ◽  
Author(s):  
Saki Nakagawa ◽  
Tetsu Akimoto ◽  
Shin-ichi Takeda ◽  
Mari Okada ◽  
Atsushi Miki ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Bowel Wall ◽  
Pneumatosis Intestinalis ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Current Case ◽  
Anca Associated Vasculitis ◽  
Characteristic Imaging

Pneumatosis intestinalis is a characteristic imaging phenomenon indicating the presence of gas in the bowel wall. The link between pneumatosis intestinalis and various kinds of autoimmune diseases has been reported anecdotally, while information regarding the cases with antineutrophil cytoplasmic antibodies (ANCA)–associated vasculitis complicated by concurrent pneumatosis intestinalis is lacking. In this report, we describe our serendipitous experience with one such case of pneumatosis intestinalis in a patient with ANCA-associated glomerulonephritis. We also discuss several therapeutic concerns that arose in the current case, which had an impact on the pathogenesis of the disease.

scholarly journals Autoimmune Diseases in Children and Adults With Type 1 Diabetes From the T1D Exchange Clinic Registry

2016 ◽  
Vol 101 (12) ◽  
pp. 4931-4937 ◽  
Author(s):  
Jing W. Hughes ◽  
Tonya D. Riddlesworth ◽  
Linda A. DiMeglio ◽  
Kellee M. Miller ◽  
Michael R. Rickels ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Autoimmune Diseases ◽  
Medical Records ◽  
Age Groups ◽  
Vascular Diseases ◽  
Older Individuals ◽  
Collagen Vascular Diseases ◽  
Race Ethnicity ◽  
Hispanic White

Background and Aims: Type 1 diabetes (T1D) is associated with other autoimmune diseases (AIDs), but the prevalence and associated predictive factors for these comorbidities of T1D across all age groups have not been fully characterized. Materials and Methods: Data obtained from 25 759 participants with T1D enrolled in the T1D Exchange Registry were used to analyze the types and frequency of AIDs as well as their relationships to gender, age, and race/ethnicity. Diagnoses of autoimmune diseases, represented as ordinal categories (0, 1, 2, 3, or more AIDs) were obtained from medical records of Exchange Registry participants. Results: Among the 25 759 T1D Exchange participants, 50% were female, 82% non-Hispanic white, mean age was 23.0 ± 16.9 years and mean duration of diabetes was 11 years. Of these participants, 6876 (27%) were diagnosed with at least one AID. Frequency of two or more AIDs increased from 4.3% in participants aged younger than 13 years to 10.4% in those aged 50 years or older. The most common AIDs were thyroid (6097, 24%), gastrointestinal (1530, 6%), and collagen vascular diseases (432, 2%). Addison’s disease was rare (75, 0.3%). The prevalence of one or more AIDs was increased in females and non-Hispanic whites and with older age. Conclusions: In the T1D Exchange Clinic Registry, a diagnosis of one or more AIDs in addition to T1D is common, particularly in women, non-Hispanic whites, and older individuals. Results of this study have implications for both primary care and endocrine practice and will allow clinicians to better anticipate and manage the additional AIDs that develop in patients with T1D.

Selenium and Autoimmune Diseases: A Review Article

2019 ◽  
Vol 15 (2) ◽  
pp. 123-134 ◽  
Author(s):  
Maryam Sahebari ◽  
Zahra Rezaieyazdi ◽  
Mandana Khodashahi
Keyword(s):  
Autoimmune Diseases ◽  
Rheumatic Diseases ◽  
Vascular Diseases ◽  
Antiphospholipid Antibody ◽  
Collagen Vascular Diseases ◽  
Autoimmune Rheumatic Diseases ◽  
Review Articles ◽  
Management Of Complications ◽  
Consensus Statements

Background:Selenium is an essential trace element with fundamental effects on human biology. Trace elements deficiency is not an uncommon finding in autoimmune diseases. This deficiency may be a consequence of autoimmune diseases or may contribute to their etiology. With regard to evidence showing the association between selenium deficiency and generation of reactive oxygen species and subsequent inflammation, reviewing the role of selenium in collagen vascular diseases could help researchers to devise strategies for managing these diseases.Objective:The present study aimed to evaluate the role of selenium and autoimmune rheumatic diseases.Data Sources:PubMed, Scopus, Science Direct, and Google Scholar.Study Eligibility Criteria:All the studies on the use of selenium without any limitations in terms of the preparation method, administration route, or formulation process were included in the study. The exclusion criteria were: 1) Articles published in languages other than English, 2) Administration of chemical and hormonal drugs rather than selenium, 3) Investigation of the effects of selenium on the autoimmune problems in animal models, and 4) Insufficiency of the presented data or poor description of the applied methods. Furthermore, review articles, meta-analyses, expert opinions, editorial letters, case reports, consensus statements, and qualitative studies were excluded from the study.Data Extraction:In this systematic review, articles were evaluated through searching following keywords in combination with selenium: "autoimmune rheumatic diseases "or "scleroderma" or "systemic sclerosis" or "Behcet's disease" or "Sjögren syndrome" or "systemic lupus erythematosus" or "musculoskeletal diseases" or "rheumatoid arthritis" or "vasculitis" or "seronegative arthritis" or "antiphospholipid antibody syndrome".Results:Of 312 articles, 280 were excluded and 32 articles were entered in this study. Based on the majority of studies assessing selenium level in patients with collagen vascular diseases, lower selenium levels were observed in these patients. Moreover, the majority of articles showed an improvement in clinical symptoms of collagen vascular diseases compared to controls after the treatment of patients with different dosages of L-selenomethionine.Conclusion:A decrease in the serum level of selenium was noted in patients with autoimmune diseases, which may be a risk factor for inflammation and initiation of autoimmunity in these patients. A sufficient quantity of selenium has been shown to contribute to the management of complications of autoimmune diseases and even improved survival in patients with autoimmune diseases, which may be due to the anti-inflammatory effects of selenium. Since this issue is of clinical importance, it can be considered in potential nutrition interventions and have beneficial effects on some autoimmune diseases.

Idiopathic Lung Diseases Other than Pulmonary Fibrosis

2017 ◽  
Author(s):  
Lawrence A Ho ◽  
Bridget F Collins ◽  
Ganesh Raghu
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Lung Disease ◽  
Lung Diseases ◽  
Vascular Diseases ◽  
Basement Membranes ◽  
European Respiratory Society ◽  
Drug Induced ◽  
Collagen Vascular Diseases ◽  
Diffuse Parenchymal Lung Diseases

Idiopathic lung diseases are diffuse parenchymal lung diseases that are grouped under the term interstitial lung disease (ILD). The term interstitial (or interstitium) is, however, misleading as the term interstitium refers to the microscopic anatomic space between the basement membranes of the endothelial and epithelial cells. The pathologic processes involved in these diseases, however, are not limited to the interstitium and can affect other elements of the gas exchange units as well as bronchiolar lumen, terminal bronchioles, pulmonary parenchyma, and pleural and vascular spaces. Since there are potentially hundreds of agents and clinical situations that are associated with ILD, a simplified grouping scheme includes seven main entities: ILD associated with (1) occupational and environmental factors (inhalation cause), (2) collagen vascular diseases, (3) granulomatous lung disease of known and unknown causes (eg, hypersensitivity pneumonitis [HP], sarcoidosis), (4) inherited diseases, (5) iatrogenic/drug induced, (6) certain specific entities (eg, pulmonary Langerhans cell histiocytosis [PLCH], lymphangioleimyomatosis, and (7) idiopathic interstitial pneumonia (IIP). As idiopathic pulmonary fibrosis (IPF) is a subgroup of IIP, this review focuses on the clinical features and management of the major IIPs, and IPF is discussed more in the review, “Idiopathic Pulmonary Fibrosis,” found elsewhere in this publication. This review also focuses on HP as it is a key disease in the differential diagnosis of the IIPs. Figures depict chest radiographs, high resolution computed topography (HRCT) scans, and histopathologic features of various ILDs. Tables list the American Thoracic Society (ATS) and the European Respiratory Society (ERS) classification of IIPs, and common antigens associated with HP and their potential sources. This review contains 22 highly rendered figures, 2 tables, and 156 references.

Idiopathic Lung Diseases Other than Pulmonary Fibrosis

2017 ◽  
Author(s):  
Lawrence A Ho ◽  
Bridget F Collins ◽  
Ganesh Raghu
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Lung Disease ◽  
Lung Diseases ◽  
Vascular Diseases ◽  
Basement Membranes ◽  
European Respiratory Society ◽  
Drug Induced ◽  
Collagen Vascular Diseases ◽  
Diffuse Parenchymal Lung Diseases

Idiopathic lung diseases are diffuse parenchymal lung diseases that are grouped under the term interstitial lung disease (ILD). The term interstitial (or interstitium) is, however, misleading as the term interstitium refers to the microscopic anatomic space between the basement membranes of the endothelial and epithelial cells. The pathologic processes involved in these diseases, however, are not limited to the interstitium and can affect other elements of the gas exchange units as well as bronchiolar lumen, terminal bronchioles, pulmonary parenchyma, and pleural and vascular spaces. Since there are potentially hundreds of agents and clinical situations that are associated with ILD, a simplified grouping scheme includes seven main entities: ILD associated with (1) occupational and environmental factors (inhalation cause), (2) collagen vascular diseases, (3) granulomatous lung disease of known and unknown causes (eg, hypersensitivity pneumonitis [HP], sarcoidosis), (4) inherited diseases, (5) iatrogenic/drug induced, (6) certain specific entities (eg, pulmonary Langerhans cell histiocytosis [PLCH], lymphangioleimyomatosis, and (7) idiopathic interstitial pneumonia (IIP). As idiopathic pulmonary fibrosis (IPF) is a subgroup of IIP, this review focuses on the clinical features and management of the major IIPs, and IPF is discussed more in the review, “Idiopathic Pulmonary Fibrosis,” found elsewhere in this publication. This review also focuses on HP as it is a key disease in the differential diagnosis of the IIPs. Figures depict chest radiographs, high resolution computed topography (HRCT) scans, and histopathologic features of various ILDs. Tables list the American Thoracic Society (ATS) and the European Respiratory Society (ERS) classification of IIPs, and common antigens associated with HP and their potential sources. This review contains 22 highly rendered figures, 2 tables, and 156 references.

scholarly journals Interstitial lung diseases in women

2013 ◽  
Vol 66 (suppl. 1) ◽  
pp. 113-117
Author(s):  
Ljudmila Nagorni-Obradovic ◽  
Ruza Stevic ◽  
Jelica Videnovic-Ivanov ◽  
Violeta Mihailovic-Vucinic ◽  
Dragica Pesut ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Lung Diseases ◽  
Wide Spectrum ◽  
Vascular Diseases ◽  
Progressive Systemic Sclerosis ◽  
Female Gender ◽  
Underlying Disease ◽  
Interstitial Lung Diseases ◽  
Collagen Vascular Diseases ◽  
Unknown Reason

Introduction. Interstitial lung diseases include a heterogeneous group of disorders that may affect men and women, but some of them are more frequent in females. Therefore, it is very important to take into account the female gender as a specific risk factor for some of these diseases. Discussion and Review of Literature. Interstitial lung diseases in women include the following: 1. diseases specific for female gender such as lymphangioleiomyomatosis, 2. disorders predominant in women due to the underlying disease (breast cancer and collagen vascular diseases: systemic lupus erythematosus, rheumatoid arthritis, progressive systemic sclerosis, dermatomyositis and polymyositis, Sj?gren syndrome), 3. idiopathic lung diseases predominant in women such an idiopathic eosinophilic pneumonia, 4. interstitial lung diseases predominant in women for unknown reason. All of these diseases have a wide spectrum of thoracic manifestations. Chest x-ray is a basic method for the detection, but computerized tomography is more useful for the assessment of the extensivity of parenchymal, airway and pleural manifestations of these diseases. Conclusion. A great variety of manifestations of interstitial lung diseases in women makes their detailed review impossible. Therefore, this article gives a short and overall review of these conditions.

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