scholarly journals Ulcerative Colitis and Sweet’s Syndrome: A Case Report and Review of the Literature

2008 ◽  
Vol 22 (3) ◽  
pp. 296-298 ◽  
Author(s):  
Massud Ali ◽  
Donald R Duerksen
Keyword(s):  
Ulcerative Colitis ◽  
Immunosuppressive Therapy ◽  
Neutrophilic Dermatosis ◽  
Sweet’S Syndrome ◽  
Review Of The Literature ◽  
Neutrophilic Infiltration ◽  
Drug Induced ◽  
Sweet's Syndrome ◽  
History Of ◽  
Inflammatory Bowel

A 47-year-old man with a history of ulcerative colitis on prednisone and azathioprine was admitted to the hospital with a four-day history of fever, skin rash, arthralgias and leukocytosis. A skin biopsy demonstrated neutrophilic infiltration of the dermis that was consistent with Sweet’s syndrome. He improved after several days with an increase in his prednisone and azathioprine. Sweet’s syndrome is a rare cutaneous manifestation of inflammatory bowel disease, with approximately 40 cases reported in the literature. In a previously reported case of a patient with ulcerative colitis-associated Sweet’s syndrome who was on azathioprine at the time of the skin eruption, the azathioprine was stopped, raising the possibility of drug-induced Sweet’s syndrome. In the present case, the azathioprine was actually increased with complete resolution of the skin manifestations. This would support the theory that immunosuppressive therapy is the mainstay of therapy for this condition. In conclusion, Sweet’s syndrome is a neutrophilic dermatosis that is rarely associated with ulcerative colitis. It may occur while on immunosuppressive therapy and responds to an intensification of immunosuppression.

Case Report of Sweet’s Syndrome Associated With Autoimmune Hepatitis

2016 ◽  
Vol 21 (1) ◽  
pp. 72-74 ◽  
Author(s):  
Allison K. Cinats ◽  
Richard M. Haber
Keyword(s):  
Autoimmune Hepatitis ◽  
Neutrophilic Dermatosis ◽  
Sweet’S Syndrome ◽  
Drug Induced ◽  
Sweet's Syndrome ◽  
Clinical Presentations ◽  
Neutrophilic Dermatoses ◽  
History Of ◽  
Erythematous Plaques ◽  
Elevated Transaminases

Autoimmune hepatitis is a subtle diagnosis that has many diverse clinical presentations. It has been reported in the literature to occur concomitantly with pyoderma gangrenosum, a neutrophilic dermatosis. Sweet’s syndrome is another neutrophilic dermatosis and has been reported to be associated with autoimmune hepatitis in only 2 previous cases: 1 idiopathic and 1 drug induced. Here we report a third case in a 24-year-old woman diagnosed with Sweet’s syndrome in association with autoimmune hepatitis, documenting a possible trend between neutrophilic dermatoses and autoimmune hepatitis. The patient presented with a history of fever and tender, erythematous plaques on her legs. Skin biopsy of a plaque confirmed histiocytoid Sweet’s syndrome. Initial laboratory investigations revealed elevated transaminases, and liver biopsy confirmed autoimmune hepatitis. This case suggests autoimmune hepatitis should be considered as an association when investigating a patient with Sweet’s syndrome.

scholarly journals Association of Sweet's Syndrome and Systemic Lupus Erythematosus

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
J. L. Barton ◽  
L. Pincus ◽  
J. Yazdany ◽  
N. Richman ◽  
T. H. McCalmont ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Neutrophilic Dermatosis ◽  
Sweet’S Syndrome ◽  
Systemic Lupus ◽  
Drug Induced ◽  
Sweet's Syndrome ◽  
Acute Febrile Neutrophilic Dermatosis ◽  
Cytokine Dysregulation ◽  
Exact Relationship

Sweet's syndrome is an acute febrile neutrophilic dermatosis which usually presents as an idiopathic disorder but can also be drug induced, associated with hematopoetic malignancies and myelodysplastic disorders, and more, infrequently, observed in autoimmune disorders. Sweet's syndrome has been reported in three cases of neonatal lupus, three cases of hydralazine-induced lupus in adults, and in nine pediatric and adult systemic lupus erythematosus (SLE) patients. We describe three additional adult cases of Sweet's associated with SLE and provide a focused review on nondrug-induced, nonneonatal SLE and Sweet's. In two of three new cases, as in the majority of prior cases, the skin rash of Sweet's paralleled underlying SLE disease activity. The pathogenesis of Sweet's remains elusive, but evidence suggests that cytokine dysregulation may be central to the clinical and pathological changes in this condition, as well as in SLE. Further research is needed to define the exact relationship between the two conditions.

scholarly journals Sweet’s syndrome and mucosal prolapse polyps in a male patient with ulcerative colitis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xixian Zhao ◽  
Si Jiang ◽  
Yanan Chen ◽  
Jialong Liu ◽  
Jing Liu ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Male Patient ◽  
Mucosal Prolapse ◽  
Neutrophilic Dermatosis ◽  
Sweet’S Syndrome ◽  
Epstein Barr Virus Infection ◽  
Sweet's Syndrome ◽  
Barr Virus ◽  
Acute Febrile Neutrophilic Dermatosis ◽  
Dermal Infiltrate

Abstract Background Sweet’s syndrome (SS), also known as acute febrile neutrophilic dermatosis, is a rare neutrophilic dermatitis characterized by pyrexia, neutrophilia and painful papulonodular lesions with a neutrophilic dermal infiltrate. Case presentation We presented a case report of classical SS associated with ulcerative colitis (UC) and mucosal prolapse polyps (MPPs) in a male patient. Conclusions The particularity of this case is the occurrence of MPPs in a male patient with UC and classical SS. We also discussed whether this patient with concurrent Epstein–Barr virus infection could be treated with corticosteroids.

scholarly journals Sweet’s Syndrome: A Classical Presentation of a Rare Disease

2019 ◽  
Vol 7 ◽  
pp. 232470961989516
Author(s):  
Arash Mollaeian ◽  
Hadi Roudsari ◽  
Ebrahim Talebi
Keyword(s):  
Rare Disease ◽  
Skin Lesions ◽  
Rare Disorder ◽  
Neutrophilic Dermatosis ◽  
Sweet’S Syndrome ◽  
Drug Induced ◽  
Sweet's Syndrome ◽  
Viral Illness ◽  
Acute Febrile Neutrophilic Dermatosis ◽  
Rapid Appearance

Sweet’s syndrome, also known as acute febrile neutrophilic dermatosis, is a rare disorder that typically presents with rapid appearance of tender skin lesions accompanied by fever and leukocytosis with neutrophilia. Its pathogenesis is not fully understood. The syndrome is generally classified into classical, malignancy-associated, and drug-induced categories, each of which has its specific characteristics. In this article, we present a case of classical Sweet’s syndrome in a woman who presented with an acute viral illness.

scholarly journals Sweet’s Syndrome Successfully Treated with Granulocyte and Monocyte Adsorption Apheresis

2017 ◽  
Vol 9 (2) ◽  
pp. 13-18 ◽  
Author(s):  
Asami Fujii ◽  
Yoko Mizutani ◽  
Yuki Hattori ◽  
Tomoko Takahashi ◽  
Hidenori Ohnishi ◽  
...  
Keyword(s):  
Elevated Serum ◽  
Japanese Woman ◽  
Neutrophilic Dermatosis ◽  
Sweet’S Syndrome ◽  
Drug Induced ◽  
Laboratory Findings ◽  
Sweet's Syndrome ◽  
Amyloid A ◽  
Normal Ranges ◽  
Serum Amyloid A Protein

Sweet’s syndrome is a neutrophilic dermatosis characterized by an abrupt onset of painful erythematous lesions showing neutrophilic infiltrates in the dermis. Fever and an elevated neutrophil level are generally observed. Sweet’s syndrome may be idiopathic, malignancy-associated, or drug-induced (mainly involving granulocyte colony-stimulating factor (G-CSF) administration). Although systemic corticosteroids are usually effective, the symptoms of Sweet’s syndrome recur in some refractory cases. Herein, we report a case of a 55-year-old Japanese woman with recurrent symptoms of fever (>39°C) and painful erythematous lesions on her four extremities, trunk, and neck. Laboratory findings revealed leukocytosis and high levels of C-reactive protein (CRP) and G-CSF. She was diagnosed with a recurrence of Sweet’s syndrome, and was exclusively treated with granulocyte and monocyte adsorption apheresis (GMA) therapy once a week for 3 consecutive weeks. After the first session of GMA therapy, all symptoms including the erythematous lesions and fever were completely resolved, and serum G-CSF level was reduced. Leukocyte count, neutrophil count, serum amyloid A protein, and CRP levels were restored within normal ranges by 2 weeks. Thus, GMA therapy can successfully treat a patient with recurrent Sweet’s syndrome, potentially related to the restoration of elevated serum G-CSF levels.

scholarly journals Systemic Lupus Erythematosus in a Patient with Ulcerative Colitis: Co-Existing or Drug-Induced?

2019 ◽  
Vol 19 (02) ◽  
pp. 67-69
Author(s):  
Frances Feisi Sun ◽  
Nga Lai Chan ◽  
Tsz Ching Chan ◽  
Ka Long Leung ◽  
Yuk Wo Aaron Siu ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Lupus Erythematosus ◽  
Bowel Disease ◽  
Systemic Lupus ◽  
Drug Induced ◽  
Drug History ◽  
History Of ◽  
Inflammatory Bowel

We report a 49-year-old lady with ulcerative colitis (UC) who subsequently developed systemic lupus erythematosus (SLE) ten years later. By reviewing the drug history and serum autoimmune panel, we hypothesize that systemic lupus erythematosus may occur in a patient with a history of inflammatory bowel disease as a coexisting disease, or triggered by drugs used in inflammatory bowel disease, such as disease-modifying anti-rheumatic drugs (DMARDs). This case raises the discussion that patients with Inflammatory bowel disease (IBD) may have a genetic predisposition for developing other autoimmune diseases, and explores the possibility of drugs used in the treatment of IBD as a trigger for SLE development. Being able to differentiate the two has important implications in management and prognosis.

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