scholarly journals Malondialdehyde in Exhaled Breath Condensate as a Marker of Oxidative Stress in Different Pulmonary Diseases

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
M. L. Bartoli ◽  
F. Novelli ◽  
F. Costa ◽  
L. Malagrinò ◽  
L. Melosini ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Exhaled Breath Condensate ◽  
Inverse Correlation ◽  
Control Group ◽  
Chronic Obstructive ◽  
Exhaled Breath ◽  
Oxidative Stress Biomarkers ◽  
Obstructive Pulmonary Disease ◽  
Number Of Patients ◽  
Breath Condensate

Background. Oxidative stress plays a role in the pathogenesis of many chronic inflammatory lung diseases. Exhaled breath condensate (EBC) collection is a noninvasive method to investigate pulmonary oxidative stress biomarkers such as malondialdehyde (MDA).Subjects and Methods. We measured MDA levels in EBC in a large number of patients (N=194) with respiratory diseases: asthma (N=64), bronchiectasis (BE,N=19), chronic obstructive pulmonary disease (COPD,N=73), idiopathic pulmonary fibrosis (IPF,N=38). Fourteen healthy nonsmoking subjects were included as controls.Results. Excluding IPF subjects, MDA levels were significantly higher in all disease groups than in control group. MDA was significantly higher in COPD than asthmatic and BE subjects. Among asthmatics, corticosteroids-treated subjects had lower MDA levels than untreated subjects. COPD subjects showed an inverse correlation between MDA concentrations and FEV1% (rho: −0.24,P<.05).Conclusions. EBC-MDA is increased in subjects with chronic airway disorders, particularly in COPD, and it is related to FEV1reduction.

Assessment of airway inflammation in chronic obstructive pulmonary disease: Biomarkers in exhaled breath condensate

2012 ◽  
Vol 153 (22) ◽  
pp. 843-851 ◽  
Author(s):  
Balázs Antus
Keyword(s):  
Oxidative Stress ◽  
Chronic Obstructive Pulmonary Disease ◽  
Airway Inflammation ◽  
Pulmonary Disease ◽  
Tissue Injury ◽  
Exhaled Breath Condensate ◽  
Chronic Obstructive ◽  
Exhaled Breath ◽  
Obstructive Pulmonary Disease ◽  
Breath Condensate

Airway inflammation plays a central role in the pathophysiology of chronic obstructive pulmonary disease. Exposure to cigarette smoke induces the recruitment of inflammatory cells in the airways, which in turn produces various cytokines, chemokines, proteases and pro-inflammatory mediators leading ultimately to increased oxidative stress, a protease/anti-protease imbalance and progressive lung tissue injury. Biomarkers may be useful in monitoring airway inflammation and oxidative stress, defining different phenotypes of the disease and evaluating the response of therapies. Exhaled breath condensate collection is a simple and completely non-invasive method of sampling the lower respiratory tract in humans. Exhaled breath condensate may be a rich source of pulmonary biomarkers including hydrogen peroxide, cytokines, metabolites of the arachidonic acid, nitric oxides and the pH. However, the concentration of these biomarkers is often very low, which may cause several problems in their detection. The clinical applicability of exhaled breath condensate biomarkers cannot be assessed until methods of sample collection and analysis have been standardized. Orv. Hetil., 2012, 153, 843–851.

scholarly journals Biomarkers in Exhaled Breath Condensate and Serum of Chronic Obstructive Pulmonary Disease and Non-Small-Cell Lung Cancer

2013 ◽  
Vol 2013 ◽  
pp. 1-15 ◽  
Author(s):  
Mann Ying Lim ◽  
Paul S. Thomas
Keyword(s):  
Oxidative Stress ◽  
Lung Cancer ◽  
Chronic Obstructive Pulmonary Disease ◽  
Exhaled Breath Condensate ◽  
Small Cell ◽  
Chronic Obstructive ◽  
Exhaled Breath ◽  
Small Cell Lung ◽  
Obstructive Pulmonary Disease ◽  
Breath Condensate

Chronic obstructive pulmonary disease (COPD) and lung cancer are leading causes of deaths worldwide which are associated with chronic inflammation and oxidative stress. Lung cancer, in particular, has a very high mortality rate due to the characteristically late diagnosis. As such, identification of novel biomarkers which allow for early diagnosis of these diseases could improve outcome and survival rate. Markers of oxidative stress in exhaled breath condensate (EBC) are examples of potential diagnostic markers for both COPD and non-small-cell lung cancer (NSCLC). They may even be useful in monitoring treatment response. In the serum, S100A8, S100A9, and S100A12 of the S100 proteins are proinflammatory markers. They have been indicated in several inflammatory diseases and cancers including secondary metastasis into the lung. It is highly likely that they not only have the potential to be diagnostic biomarkers for NSCLC but also prognostic indicators and therapeutic targets.

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