scholarly journals The Role of Macrolides in Childhood Non-Cystic Fibrosis-Related Bronchiectasis

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
R. Masekela ◽  
R. J. Green
Keyword(s):  
Quality Of Life ◽  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Lung Disease ◽  
Mucociliary Clearance ◽  
Improve Quality ◽  
Immunomodulatory Properties ◽  
Impaired Quality

Non-cystic fibrosis-related bronchiectasis is a chronic inflammatory lung disease, which is regarded as an “orphan” lung disease, with little research devoted to the study of this condition. Bronchiectasis results in impaired quality of life and mortality if left untreated. The tools available in the armamentarium for the management of bronchiectasis entail antibiotic therapy traditionally used to treat exacerbations, stratagems to improve mucociliary clearance, and avoidance of toxins. Macrolides have been known for the last two decades to have not only anti-bacterial effects but immunomodulatory properties as well. In cystic fibrosis, the use of macrolides is well documented in subjects colonized withPseudomonas aeruginosa, to improve quality of life and lung function. There is currently emerging evidence to suggest the benefit of macrolides in subjects not colonized withPseudomonas aeruginosa. This beneficial effect has been less explored in the context of bronchiectasis from other causes. The purpose of this paper is to review the current literature on the use of macrolides in non-cystic fibrosis related bronchiectasis in paediatrics.

scholarly journals Periodontal, metabolic, and cardiovascular disease: Exploring the role of inflammation and mental health

Pteridines ◽  
2018 ◽  
Vol 29 (1) ◽  
pp. 124-163 ◽  
Author(s):  
Hina Makkar ◽  
Mark A. Reynolds ◽  
Abhishek Wadhawan ◽  
Aline Dagdag ◽  
Anwar T. Merchant ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Therapeutic Interventions ◽  
Improve Quality ◽  
Previous Evidence ◽  
Cascading Effects ◽  
Reciprocal Interactions ◽  
Cardiovascular Morbidity And Mortality ◽  
Potential Interactions

AbstractPrevious evidence connects periodontal disease, a modifiable condition affecting a majority of Americans, with metabolic and cardiovascular morbidity and mortality. This review focuses on the likely mediation of these associations by immune activation and their potential interactions with mental illness. Future longitudinal, and ideally interventional studies, should focus on reciprocal interactions and cascading effects, as well as points for effective preventative and therapeutic interventions across diagnostic domains to reduce morbidity, mortality and improve quality of life.

scholarly journals The role of the trainer in adapted physical activity for osteoporosis to improve quality of life

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
S Marini ◽  
A Masini ◽  
P Maietta Latessa ◽  
T Sanna ◽  
A Raggi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Control Group ◽  
Improve Quality ◽  
Adapted Physical Activity ◽  
Structured Interviews ◽  
Substantial Impact

Abstract Background Osteoporosis is a major health burden worldwide and require a multi-modal approach including exercise. Fractures have a substantial impact on quality of life (QoL) so exercise programs may to be conducted by trainers able to deal with this condition, because exercise alone, even if in the right dosage, seems to be not enough to improve QoL. A quasi-experimental pilot study performed to determine the feasibility and safety of an Adapted Physical Activity (APA) protocol specifically designed for osteoporotic women with vertebral fractures and its effect on QoL, with a specific focus on trainer's role. Methods The Experimental Group (EG) performed APA protocol 1hour twice a week for 6 months, while the Control Group (CG) received standard care. QoL was assessed at baseline and follow-up with ECOS-16 questionnaire and semi structured interviews to understand women perceptions regarding trainer's role. Using mixed-methods quantitative and qualitative data were analyzed using SPSS 5 and NVivo 12, respectively. Results 40 post-menopausal women (mean age: 67.6±4.6) divided in 2 groups EG = 22 and CG = 18, completed the study. At follow-up, EG improved significantly QoL (EG: -0.5±0.5 vs CG: 0.0±0.3 p = 0.02). The APA intervention had a significant effect on all the components of QoL, as measured by the disease-specific ECOS-16 questionnaire: Physical Component Summary (PCS) (EG: -0.4±0.5 vs CG: 0.0±0.4 p = 0.06) and Mental Component Summary (MCS) (EG: -0.5±0.6 vs CG: 0.1±0.5 p = 0.02). The interviews confirmed this result, emphasizing the key role of the trainer in improving their QoL. The adherence calculated as number of sessions performed compared to the sessions proposed was 75.8%. No injuries were observed. Conclusions The feasibility, the safety, and the positive effect of the proposed exercise protocol on QoL confirmed also by the interviews, show that principles of exercise education applied by trainers should be extended also to patients with other chronic condition. Key messages Trainers specifically educated, could be a means of achieving the goal improving people’s QoL, as they occupy the role of exercise experts and also an educational, relational and support role. The management of osteoporosis is multi-modal and includes exercise, often recommended as a beneficial non-pharmacological treatment to slow the rate of bone loss and improve quality of life.

scholarly journals Management of chronic Pseudomonas aeruginosa infection with inhaled levofloxacin in people with cystic fibrosis

2021 ◽  
Author(s):  
J Stuart Elborn ◽  
Patrick A Flume ◽  
Donald R Van Devanter ◽  
Claudio Procaccianti
Keyword(s):  
Quality Of Life ◽  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Lung Function ◽  
Standard Care ◽  
Bacterial Infections ◽  
Pulmonary Infections ◽  
Pseudomonas Aeruginosa Infection

People with cystic fibrosis (CF) are highly susceptible to bacterial infections of the airways. By adulthood, chronic Pseudomonas aeruginosa ( Pa) is the most prevalent infective organism and is difficult to eradicate owing to its adaptation to the CF lung microenvironment. Long-term suppressive treatment with inhaled antimicrobials is the standard care for reducing exacerbation frequency, improving quality of life and increasing measures of lung function. Levofloxacin (a fluoroquinolone antimicrobial) has been approved as an inhaled solution in Europe and Canada, for the treatment of adults with CF with chronic P. aeruginosa pulmonary infections. Here, we review the clinical principles relating to the use of inhaled antimicrobials and inhaled levofloxacin for the management of P. aeruginosa infections in patients with CF.

P391 Can nurse-provided education improve quality of life in patients with cystic fibrosis?

2020 ◽  
Vol 19 ◽  
pp. S165
Author(s):  
T. Odobasic Palkovic ◽  
D. Tjesic-Drinkovic ◽  
D. Tjesic-Drinkovic ◽  
I. Godic ◽  
I. Lalic ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cystic Fibrosis ◽  
Improve Quality

Relationship Between Personality Traits, Generativity, and Life Satisfaction in Individuals Attending University Programs for Seniors

2017 ◽  
Vol 87 (2) ◽  
pp. 184-200 ◽  
Author(s):  
Ana Belen Navarro-Prados ◽  
Sara Serrate-Gonzalez ◽  
Jose-Manuel Muñoz-Rodríguez ◽  
Unai Díaz-Orueta
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Life Satisfaction ◽  
Personality Traits ◽  
Intervention Programs ◽  
Improve Quality ◽  
Sociodemographic Data ◽  
The University

Personality traits of older adults and their contribution to life satisfaction and generative interest were assessed. A total of 342 older participants (66% women), mean age = 67.89 years old ( SD = 6.52, range = 55–84 years old), who attended the University of the Experience in Salamanca (Spain), were evaluated. Information on sociodemographic data, perceived health and activity, personality traits, generativity, and life satisfaction was collected using self-reported questionnaires. Results confirmed a relation between personality traits, life satisfaction, and generativity. In addition, generative concern, neuroticism, extraversion, agreeableness, and conscientiousness predicted life satisfaction at this stage. Moreover, the role of personality on generativity was confirmed. Individuals with interest and agreeableness toward others, who are organized, persistent, and motivated, are more predisposed to generativity. These results open the way to develop intervention programs that enhance positive personality traits and generative interest to improve quality of life of older people.

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