scholarly journals New 1,2,3-Triazole Iminosugars Derivatives Using Click Chemistry

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Chahrazed Benhaoua
Keyword(s):  
Click Chemistry ◽  
Good Yield ◽  
Terminal Alkynes ◽  
Synthetic Pathway

The click concept refers ease, efficient, and the selective chemicals transformations. In this study, a novel regiospecific copper (I)-catalyzed 1, 3-dipolar of terminal alkynes to azide provided a practicable synthetic pathway of triazole iminosugars derivatives. A series of new triazole-pyrrolidinols are reported in good yield.

Click Chemistry: Copper Clusters Catalyse the Cycloaddition of Azides with Terminal Alkynes

2005 ◽  
Vol 347 (6) ◽  
pp. 811-815 ◽  
Author(s):  
Laura Durán Pachón ◽  
Jan H. van Maarseveen ◽  
Gadi Rothenberg
Keyword(s):  
Click Chemistry ◽  
Terminal Alkynes ◽  
Copper Clusters

scholarly journals Formation of 8-RS-BODIPYs via direct substitution of 8-MeS-BODIPY by RSH (R = Et, Pr, Bu, tBu, n-C12H25, C6H5, p-MeC6H4, p-MeOC6H4, and 2,6-Me2C6H3)

2016 ◽  
Vol 94 (3) ◽  
pp. 234-239 ◽  
Author(s):  
Robinson I. Roacho ◽  
Alejandro Metta-Magaña ◽  
José L. Belmonte-Vázquez ◽  
Eduardo Peña-Cabrera ◽  
Keith H. Pannell
Keyword(s):  
Single Crystal ◽  
Fluorescence Intensity ◽  
Good Yield ◽  
Solvent Polarity ◽  
Aryl Group ◽  
Synthetic Pathway ◽  
X Ray ◽  
Emission Properties ◽  
Alkyl Derivatives ◽  
Direct Substitution

Reactions between 8-RS-BODIPY (R = Me, 1) and alkyl and aryl thiols were readily accomplished in dichloromethane to provide a synthetic pathway to a range of new 8-organothio-BODIPYs in good yield. The new alkyl 8-RS-BODIPYs (R = Et, 2; Pr, 3; Bu, 4; tBu, 5; n-dodecyl, 6) exhibit absorption and emission properties essentially unchanged from those of 1 whereas the arylthio analogs (R = Ph, 7; 2,6-Me2C6H3, 8; p-MeC6H4, 9; p-MeOC6H4, 10) exhibit no fluorescence with the exception of 7, and then only in hexane. In common with other related 8-substituted BODIPYs, the new 8-alkylthio-BODIPY dyes show decreasing fluorescence intensity as solvent polarity increases. Compounds 2, 3, 7, and 8 were characterized via single-crystal X-ray analysis; the alkyl derivatives 2 and 3 exhibited planar BODIPY cores with co-planar organothio- substituents whereas the aryl derivatives exhibited both BODIPY core deformation and significant twisting about the S–C (8) bond removing co-planarity between the aryl group and the distorted BODIPY core. These deformations coincide with the significantly reduced emission properties.

Copper nanoparticles in click chemistry: an alternative catalytic system for the cycloaddition of terminal alkynes and azides

2009 ◽  
Vol 50 (20) ◽  
pp. 2358-2362 ◽  
Author(s):  
Francisco Alonso ◽  
Yanina Moglie ◽  
Gabriel Radivoy ◽  
Miguel Yus
Keyword(s):  
Click Chemistry ◽  
Catalytic System ◽  
Copper Nanoparticles ◽  
Terminal Alkynes

New Stable Cu(I) Catalyst Supported on Weakly Acidic Polyacrylate Resin for “Click” Chemistry: Synthesis of 1,2,3-Triazole and Novel Synthesis of 1,2,3-Triazol-5-amine

2018 ◽  
Vol 15 (4) ◽  
pp. 552-565 ◽  
Author(s):  
Nitin Kore ◽  
Pavel Pazdera
Keyword(s):  
Click Chemistry ◽  
Nucleophilic Substitution ◽  
Cyano Group ◽  
Catalytic Action ◽  
Cycloaddition Reactions ◽  
Terminal Alkynes ◽  
Terminal Alkyne ◽  
Aryl Azide ◽  
Catalytic Application ◽  
Novel Synthesis

Aim and Objective: The aim of our work is to demonstrate catalytic application of our previously reported simple Cu(I) ion supported on weakly acidic polyacrylate resin for Azide-Alkyne cycloaddition (CuAAC), Azide-Nitrile cycloaddition and in synthesis of 1-azido-4-methoxybenzene. Material and Method: To investigate the catalytic ability of title Cu(I) catalyst we performed the reaction of different aryl azide with a broader spectrum of different terminal alkyne and nitrile compounds. Results: The title supported Cu(I) catalyzes cycloaddition reactions of aryl azide with aliphatic, aromatic, and heterocyclic terminal alkynes and corresponding 1,4-disubstituted 1,2,3-triazoles were obtained almost in the quantitative yields. The cycloaddition reactions of aryl azide with nitriles consisting α-hydrogen on carbon attached to cyano group under catalytic action of the title supported Cu(I) ended up with the formation of 1,4- disubstituted 1,2,3-triazol-5-amines in quantitative yields. The title catalyst found to be active for nucleophilic substitution of aide group (-N3) to 4-Iodoanisole. Conclusion: It was found that both studied Azide-Alkyne cycloaddition and Azide-Nitrile cycloaddition syntheses are regioselective and quantitative in yield. The title catalyst used is economical, easily preparable, separable, and recyclable. Therefore, the studied syntheses may be regarded as environmentally clean and green processes.

scholarly journals Cu(I) Catalyzed Coumarin-1,2,3-Triazole Hybrids: Click Chemistry

2019 ◽  
Vol 31 (11) ◽  
pp. 2543-2547 ◽  
Author(s):  
Ritu Mamgain
Keyword(s):  
Click Chemistry ◽  
Good Yield ◽  
Cycloaddition Reaction ◽  
Triazole Derivatives ◽  
Biologically Relevant

A series of novel coumarin-1,2,3-triazole derivatives were synthesized in good yield via click chemistry using Cu(I) catalyzed intermolecular Huisgen [3+2] cycloaddition reaction. All the synthesized compounds were characterized spectroscopically. This piece of work could be helpful to develop biologically relevant coumarin analogs.

Synthesis, Characterization and Biological Evaluation of Some Novel Substitute N-(4-(3-Oxomorpholino)phenyl)-2-(4-((phenylamino)methyl)-1H- 1,2,3-triazol-1-yl)-acetamide via Click Chemistry Approach

2021 ◽  
Vol 6 (2) ◽  
pp. 107-110
Author(s):  
H.P. Pandya ◽  
K.A. Joshi
Keyword(s):  
Antimicrobial Activity ◽  
Click Chemistry ◽  
1H Nmr ◽  
Good Yield ◽  
Biological Evaluation ◽  
Structural Variations ◽  
Mass Data

A novel heterocyclic library were synthesized, characterized and tested for biological evaluation against bacteria and fungus. This novel series of substitute N-(4-(3-oxomorpholino)phenyl)-2-(4- ((phenylamino)-methyl)-1H-1,2,3-triazol-1-yl)acetamide via click chemistry approach in the presence of DMF:H2O:n-BuOH and CuSO4·5H2O in good yield. The title compounds have been synthesized with several structural variations. The synthesized compounds were screened for antimicrobial activity against standard drugs. The structure of synthesized compounds characterized by their spectral (IR, 1H NMR and mass) data. The purity of the synthesized compounds was confirmed by TLC.

A useful method for preparation of carboxylic acids from terminal alkynes

1983 ◽  
Vol 61 (10) ◽  
pp. 2423-2424 ◽  
Author(s):  
Suzanne R. Abrams
Keyword(s):  
Acetic Acid ◽  
Sulfuric Acid ◽  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Chain Length ◽  
Good Yield ◽  
Terminal Alkynes ◽  
Terminal Acetylenes ◽  
Long Chain ◽  
Acetic Acids

Substituted acetic acids can be prepared in good yield (50–80%) from terminal acetylenes of the same chain length. The alkyne is first converted to the thiophenyl ether, which is treated without purification with mercuric sulfate in acetic acid and 2 N sulfuric acid affording the carboxylic acid. The method is particularly useful in the synthesis of long chain ω-hydroxyalkanoic acids.

scholarly journals Stereoselective synthesis of (E)-vinyl alkyl sulfides via hydrozirconation of terminal alkynes

2004 ◽  
Vol 69 (3) ◽  
pp. 175-178
Author(s):  
Zhong Ping ◽  
Huang Xian
Keyword(s):  
Good Yield ◽  
Stereoselective Synthesis ◽  
Terminal Alkynes

Terminal alkynes react with Cp2Zr(H)Cl (Cp = ?5-C5H5) to give organozirconium complexes, which are trapped with alkylsulfenyl chlorides to afford (E)-vinyl alkyl sulfides in good yield.

scholarly journals Synthesis, optical, electrochemical properties and anticancer activity of (S)-BINOL cored triazole bridged dendrimers decorated with rhodamine B surface group

RSC Advances ◽  
2019 ◽  
Vol 9 (63) ◽  
pp. 36994-37002
Author(s):  
Jothinathan Sathiya Savithri ◽  
Perumal Rajakumar
Keyword(s):  
Electrochemical Properties ◽  
Anticancer Activity ◽  
Click Chemistry ◽  
Rhodamine B ◽  
Good Yield ◽  
Second Generation ◽  
Surface Group ◽  
Convergent Synthesis

(S)-BINOL cored dendrimers 1–3 with rhodamine B surface group and triazole bridging unit were synthesized up to second generation in good yield by convergent synthesis through click chemistry.

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