scholarly journals Artificial Neural Network for the Prediction of Tyrosine-Based Sorting Signal Recognition by Adaptor Complexes

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Debarati Mukherjee ◽  
Claudia B. Hanna ◽  
R. Claudio Aguilar

Sorting of transmembrane proteins to various intracellular compartments depends on specific signals present within their cytosolic domains. Among these sorting signals, the tyrosine-based motif (YXXØ) is one of the best characterized and is recognized byμ-subunits of the four clathrin-associated adaptor complexes (AP-1 to AP-4). Despite their overlap in specificity, eachμ-subunit has a distinct sequence preference dependent on the nature of the X-residues. Moreover, combinations of these residues exert cooperative or inhibitory effects towards interaction with the various APs. This complexity makes it impossible to predicta priori, the specificity of a given tyrosine-signal for a particularμ-subunit. Here, we describe the results obtained with a computational approach based on the Artificial Neural Network (ANN) paradigm that addresses the issue of tyrosine-signal specificity, enabling the prediction of YXXØ-μinteractions with accuracies over 90%. Therefore, this approach constitutes a powerful tool to help predict mechanisms of intracellular protein sorting.

2019 ◽  
Vol 24 (2) ◽  
pp. 40 ◽  
Author(s):  
Felix Selim Göküzüm ◽  
Lu Trong Khiem Nguyen ◽  
Marc-André Keip

The present work addresses a solution algorithm for homogenization problems based on an artificial neural network (ANN) discretization. The core idea is the construction of trial functions through ANNs that fulfill a priori the periodic boundary conditions of the microscopic problem. A global potential serves as an objective function, which by construction of the trial function can be optimized without constraints. The aim of the new approach is to reduce the number of unknowns as ANNs are able to fit complicated functions with a relatively small number of internal parameters. We investigate the viability of the scheme on the basis of one-, two- and three-dimensional microstructure problems. Further, global and piecewise-defined approaches for constructing the trial function are discussed and compared to finite element (FE) and fast Fourier transform (FFT) based simulations.


2021 ◽  
Vol 11 (19) ◽  
pp. 8943
Author(s):  
Rudy Alexis Guejia Burbano ◽  
Giovanni Petrone ◽  
Patrizio Manganiello

In this paper, an artificial neural network (ANN) is used for isolating faults and degradation phenomena occurring in photovoltaic (PV) panels. In the literature, it is well known that the values of the single diode model (SDM) associated to the PV source are strictly related to degradation phenomena and their variation is an indicator of panel degradation. On the other hand, the values of parameters that allow to identify the degraded conditions are not known a priori because they can be different from panel to panel and are strongly dependent on environmental conditions, PV technology and the manufacturing process. For these reasons, to correctly detect the presence of degradation, the effect of environmental conditions and fabrication processes must be properly filtered out. The approach proposed in this paper exploits the intrinsic capability of ANN to map in its architecture two effects: (1) the non-linear relations existing among the SDM parameters and the environmental conditions, and (2) the effect of the degradation phenomena on the I-V curves and, consequently, on the SDM parameters. The ANN architecture is composed of two stages that are trained separately: one for predicting the SDM parameters under the hypothesis of healthy operation and the other one for degraded condition. The variation of each parameter, calculated as the difference of the output of the two ANN stages, will give a direct identification of the type of degradation that is occurring on the PV panel. The method was initially tested by using the experimental I-V curves provided by the NREL database, where the degradation was introduced artificially, later tested by using some degraded experimental I-V curves.


2019 ◽  
Vol 12 (3) ◽  
pp. 145 ◽  
Author(s):  
Epyk Sunarno ◽  
Ramadhan Bilal Assidiq ◽  
Syechu Dwitya Nugraha ◽  
Indhana Sudiharto ◽  
Ony Asrarul Qudsi ◽  
...  

2020 ◽  
Vol 38 (4A) ◽  
pp. 510-514
Author(s):  
Tay H. Shihab ◽  
Amjed N. Al-Hameedawi ◽  
Ammar M. Hamza

In this paper to make use of complementary potential in the mapping of LULC spatial data is acquired from LandSat 8 OLI sensor images are taken in 2019.  They have been rectified, enhanced and then classified according to Random forest (RF) and artificial neural network (ANN) methods. Optical remote sensing images have been used to get information on the status of LULC classification, and extraction details. The classification of both satellite image types is used to extract features and to analyse LULC of the study area. The results of the classification showed that the artificial neural network method outperforms the random forest method. The required image processing has been made for Optical Remote Sensing Data to be used in LULC mapping, include the geometric correction, Image Enhancements, The overall accuracy when using the ANN methods 0.91 and the kappa accuracy was found 0.89 for the training data set. While the overall accuracy and the kappa accuracy of the test dataset were found 0.89 and 0.87 respectively.


2020 ◽  
Vol 38 (2A) ◽  
pp. 255-264
Author(s):  
Hanan A. R. Akkar ◽  
Sameem A. Salman

Computer vision and image processing are extremely necessary for medical pictures analysis. During this paper, a method of Bio-inspired Artificial Intelligent (AI) optimization supported by an artificial neural network (ANN) has been widely used to detect pictures of skin carcinoma. A Moth Flame Optimization (MFO) is utilized to educate the artificial neural network (ANN). A different feature is an extract to train the classifier. The comparison has been formed with the projected sample and two Artificial Intelligent optimizations, primarily based on classifier especially with, ANN-ACO (ANN training with Ant Colony Optimization (ACO)) and ANN-PSO (training ANN with Particle Swarm Optimization (PSO)). The results were assessed using a variety of overall performance measurements to measure indicators such as Average Rate of Detection (ARD), Average Mean Square error (AMSTR) obtained from training, Average Mean Square error (AMSTE) obtained for testing the trained network, the Average Effective Processing Time (AEPT) in seconds, and the Average Effective Iteration Number (AEIN). Experimental results clearly show the superiority of the proposed (ANN-MFO) model with different features.


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