scholarly journals Adult Bone Marrow: Which Stem Cells for Cellular Therapy Protocols in Neurodegenerative Disorders?

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Sabine Wislet-Gendebien ◽  
Emerence Laudet ◽  
Virginie Neirinckx ◽  
Bernard Rogister
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Neurological Disorders ◽  
Bone Marrow Stromal Cells ◽  
Cellular Therapy ◽  
Bone Marrow Cells ◽  
Cell Replacement Therapy ◽  
Adult Bone Marrow ◽  
Clinical Interest ◽  
Adult Bone

The generation of neuronal cells from stem cells obtained from adult bone marrow is of significant clinical interest in order to design new cell therapy protocols for several neurological disorders. The recent identification in adult bone marrow of stem cells derived from the neural crests (NCSCs) might explain the neuronal phenotypic plasticity shown by bone marrow cells. However, little information is available about the nature of these cells compared to mesenchymal stem cells (MSCs). In this paper, we will review all information available concerning NCSC from adult tissues and their possible use in regenerative medicine. Moreover, as multiple recent studies showed the beneficial effect of bone marrow stromal cells in neurodegenerative diseases, we will discuss which stem cells isolated from adult bone marrow should be more suitable for cell replacement therapy.

Generation of Induced Pluripotent Stem Cells by Efficient Reprogramming of Adult Bone Marrow Cells

2010 ◽  
Vol 19 (2) ◽  
pp. 229-238 ◽  
Author(s):  
Atsushi Kunisato ◽  
Mariko Wakatsuki ◽  
Yuuki Kodama ◽  
Haruna Shinba ◽  
Isao Ishida ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Bone Marrow Cells ◽  
Adult Bone Marrow ◽  
Induced Pluripotent ◽  
Adult Bone ◽  
Marrow Cells

scholarly journals Expression of murine CD38 defines a population of long-term reconstituting hematopoietic stem cells

Blood ◽  
1996 ◽  
Vol 87 (10) ◽  
pp. 4057-4067 ◽  
Author(s):  
TD Randall ◽  
FE Lund ◽  
MC Howard ◽  
IL Weissman
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Hematopoietic Stem Cells ◽  
Bone Marrow Cells ◽  
Fetal Liver ◽  
Mouse Strains ◽  
Hematopoietic Stem ◽  
Adult Bone Marrow ◽  
Adult Bone

Using a monoclonal antibody to murine CD38, we showed that a population of adult bone marrow cells that expressed the markers Sca-1 and c-kit but lacked the lineage markers Mac-1, GR-1, B220, IgM, CD3, CD4, CD8 and CD5 could be subdivided by the expression of CD38. We showed that CD38high c-kit+ Sca-1+, linlow/-cells sorted from adult bone marrow cultured with interleukin-3 (IL-3), IL-6, and kit-L produced much larger colonies in liquid culture at a greater frequency than their CD38low/- counterparts. In addition, we found that CD36low/ - cells contained most of the day-12 colony-forming units-spleen (CFU-S) but were not long-term reconstituting cells, whereas the population that expressed higher levels of CD38 contained few, but significant, day-12 CFU-S and virtually all the long-term reconstituting stem cells. Interestingly, the CD38high Sca-1+ c-kit+ linlow/- cells isolated from day-E14.5 fetal liver were also found to be long-term reconstituting stem cells. This is in striking contrast to human hematopoietic progenitors in which the most primitive hematopoietic cells from fetal tissues lack the expression of CD38. Furthermore, because antibodies to CD38 could functionally replace antibodies to Thy-1.1 in a stem cell purification procedure, the use of anti-CD38 may be more generally applicable to the purification of hematopoietic stem cells from mouse strains that do not express the Thy-1.1 allele.

Polarized neural stem cells derived from adult bone marrow stromal cells develop a rosette-like structure

2013 ◽  
Vol 49 (8) ◽  
pp. 638-652 ◽  
Author(s):  
Shahram Darabi ◽  
Taki Tiraihi ◽  
Atefeh Ruintan ◽  
Hojatt Allah Abbaszadeh ◽  
AliReza Delshad ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Neural Stem Cells ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Adult Bone Marrow ◽  
Adult Bone

Temporal HLA profiling and immunomodulatory effects of human adult bone marrow- and adipose-derived mesenchymal stem cells

2014 ◽  
Vol 9 (1) ◽  
pp. 67-79 ◽  
Author(s):  
Bhamini Purandare ◽  
Takele Teklemariam ◽  
Longmei Zhao ◽  
Basil M Hantash
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Immunomodulatory Effects ◽  
Adult Bone Marrow ◽  
Human Adult ◽  
Adult Bone

scholarly journals Morphological, molecular and functional differences of adult bone marrow- and adipose-derived stem cells isolated from rats of different ages

2012 ◽  
Vol 318 (16) ◽  
pp. 2034-2048 ◽  
Author(s):  
Cristina Mantovani ◽  
Stefania Raimondo ◽  
Maryam S. Haneef ◽  
Stefano Geuna ◽  
Giorgio Terenghi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Adipose Derived Stem Cells ◽  
Adult Bone Marrow ◽  
Functional Differences ◽  
Different Ages ◽  
Adult Bone

Ex vivo differentiation of human adult bone marrow stem cells into cardiomyocyte-like cells

2004 ◽  
Vol 324 (2) ◽  
pp. 481-488 ◽  
Author(s):  
Winston S.N. Shim ◽  
Shujia Jiang ◽  
Philip Wong ◽  
Jack Tan ◽  
Yeow Leng Chua ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Ex Vivo ◽  
Bone Marrow Stem Cells ◽  
Adult Bone Marrow ◽  
Human Adult ◽  
Adult Bone

scholarly journals The Characterization, Molecular Cloning, and Expression of a Novel Hematopoietic Cell Antigen From CD34+ Human Bone Marrow Cells

Blood ◽  
1997 ◽  
Vol 89 (8) ◽  
pp. 2706-2716 ◽  
Author(s):  
Nobuko Uchida ◽  
Zhi Yang ◽  
Jesse Combs ◽  
Olivier Pourquié ◽  
Megan Nguyen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Molecular Cloning ◽  
Bone Marrow Cells ◽  
Hematopoietic Cell ◽  
Cell Antigen ◽  
Adult Bone Marrow ◽  
Cd34 Cells ◽  
Adult Bone ◽  
Marrow Cells ◽  
Myeloid Progenitors

Abstract The adhesion molecule BEN/SC1/DM-GRASP (BEN) is a marker in the developing chicken nervous system that is also expressed on the surface of embryonic and adult hematopoietic cells such as immature thymocytes, myeloid progenitors, and erythroid progenitors. F84.1 and KG-CAM, two monoclonal antibodies to rat neuronal glycoproteins with similarity to BEN, cross-react with an antigen on rat hematopoietic progenitors, but F84.1 only also recognizes human blood cell progenitors. We have defined the antigen recognized by F84.1 as the hematopoietic cell antigen (HCA). HCA expression was detected on 40% to 70% of CD34+ fetal and adult bone marrow cells and mobilized peripheral blood cells. Precursor cell activity for long-term in vitro bone marrow cell culture was confined to the subset of CD34+ cells that coexpress HCA. HCA is expressed by the most primitive subsets of CD34+ cells, including all rhodamine 123lo, Thy-1+, and CD38−/lo CD34+ adult bone marrow cells. HCA was also detected on myeloid progenitors but not on early B-cell progenitors. We also describe here the cloning and characterization of cDNAs encoding two variants of the human HCA antigen (huHCA-1 and huHCA-2) and of a cDNA clone encoding rat HCA (raHCA). The deduced amino acid sequences of huHCA and raHCA are homologous to that of chicken BEN. Recombinant proteins produced from either human or rat HCA cDNAs were recognized by F84.1, whereas rat HCA but not human HCA was recognized by antirat KG-CAM. Expression of either form of huHCA in CHO cells conferred homophilic adhesion that could be competed with soluble recombinant huHCA-Fc. The molecular cloning of HCA and the availability of recombinant HCA should permit further evaluation of its role in human and rodent hematopoiesis.

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