Response to Acute Psychophysical Stress and 24-Hour Glycemic Control in Healthy Older People

We examined the relation between stress reactivity and 24 h glycemic control in 17 inactive, healthy older people (≥60 years) under both a novel psychophysical stress and a seated control condition. Plasma cortisol was measured over the course of the stress and recovery periods. Glycemic control was determined over the subsequent 3 h from an oral glucose tolerance test (OGTT) and over 24 hviacontinuous glucose monitoring (CGM). We observed significant (P<0.05) elevations in perceived stress, cardiovascular activity, and peak cortisol response at 30 min (10.6±3.1versus8.6±2.6 μg·dL−1, resp.) during the stress compared with the control condition; however, 3 h OGTT glucose and insulin responses were similar between conditions. The CGM data suggested a 30–40 min postchallenge delay in peak glucose response and attenuated glucose clearance over the 6 h following the stress condition, but these alterations were not statistically significant. Healthy older people may demonstrate minimal disruption in metabolic resiliency following everyday psychological stress.

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GLUCOSE TOLERANCE AND INSULIN SECRETION IN HYPERTHYROIDISM

Acta Endocrinologica ◽

10.1530/acta.0.0840576 ◽

1977 ◽

Vol 84 (3) ◽

pp. 576-587 ◽

Cited By ~ 34

Author(s):

O. Ortved Andersen ◽

Th. Friis ◽

B. Ottesen

Keyword(s):

Insulin Secretion ◽

Glucose Tolerance ◽

Glucose Tolerance Test ◽

Cell Mass ◽

Insulin Response ◽

Tolerance Test ◽

Oral Glucose ◽

Glucose Response ◽

Intravenous Glucose ◽

Insulin Responses

ABSTRACT To evaluate the glucose tolerance and insulin secretion in hyperthyroidism patients were examined in the toxic state and after they had been made euthyroid. Fasting values: In 42 untreated patients the glucose- and insulin concentrations in serum were significantly elevated. In 24 treated patients the glucose concentrations became normal, while the insulin concentrations remained elevated. Oral-glucose-tolerance test: In 20 untreated patients the glucose- and insulin responses were significantly increased. In 8 treated patients the glucose response became normal, while the insulin response remained unchanged. Intravenous-glucose-tolerance test: In 28 untreated patients the K-values were significantly decreased and the insulin response increased. In 23 treated patients the K-values rose significantly, but the insulin response remained unchanged. Intravenous-tolbutamide test: In 41 untreated patients the glucose concentration decreased significantly compared with the controls, and the insulin responses were significantly increased. In 23 treated patients the glucose concentrations decreased even more, while the insulin response remained unchanged. The results indicate enhanced sensitivity or an increase in the mass of β-cells in hyperthyroidism. The glucose tolerance tests point to an increased peripheral insulin resistance. The normalized glucose tolerance and still enhanced insulin secretion during treatment support the assumption, that hyperthyroidism causes an increase in the β-cell mass.

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