scholarly journals Extragastrointestinal Stromal Tumor during Pregnacy

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Ilay Gözükara ◽  
T. U. Kutlu Dilek ◽  
Hüseyin Durukan ◽  
Duygu Düsmez Apa ◽  
Suna Kabil Kucur ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumors ◽  
Stromal Tumor ◽  
Stromal Tumors ◽  
Cd 117 ◽  
Extragastrointestinal Stromal Tumor ◽  
Mesenchymal Neoplasms ◽  
Oncogene Protein

Extragastrointestinal stromal tumors (EGISTs) are mesenchymal neoplasms without connection to the gastrointestinal tract. Gastrointestinal stromal tumors (GISTs) and EGIST are similar according to their clinicopathologic and histomorphologic features. Both of them most often express immunoreactivity for CD-117, a c-kit proto-oncogene protein. The coexistence of GIST and pregnancy is very rare, with only two cases reported in the literature. In this paper, we presented the first EGIST case during pregnancy in the literature.

scholarly journals Primary Extra-gastrointestinal Stromal Tumor of Retroperitoneum

2012 ◽  
Vol 6 ◽  
pp. CMO.S9180 ◽  
Author(s):  
Claudio Casella ◽  
Vincenzo Villanacci ◽  
Filippo D'adda ◽  
Manuela Codazzi ◽  
Bruno Salerni
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Stromal Tumor ◽  
Radiological Evaluation ◽  
Retroperitoneal Mass ◽  
Stromal Tumors ◽  
Mesenchymal Neoplasms ◽  
Paravertebral Region ◽  
Histology And Immunohistochemistry

Background Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. More rarely neoplasms with histology and immunohistochemistry similar to GISTs may occur outside the gastrointestinal tract (omentum, mesentery and retroperitoneum) and are so-called Extra-gastrointestinal Stromal Tumors (EGISTs). EGISTs arising in the retroperitoneum are extremely rare: to date, only 58 cases have been reported in the literature. Case Report We herein report a case of a primary EGIST of the retroperitoneum surgically treated. The pre-operative radiological evaluation showed a retroperitoneal mass, placed in left paravertebral region. Results Morphological and immunohistochemical features led to a diagnosis of extra-gastrointestinal stromal tumor (intermediate-low risk form). Conclusions As a result of the rarity of reports of primary EGISTs of retroperitoneum we need to analyze the data of reported cases in order to gain a better understanding about the pathogenesis, prognosis and optimal treatment of this disease.

scholarly journals Giant gastrointestinal stromal tumor of ileum: the gist of GIST: a case report

2017 ◽  
Vol 4 (3) ◽  
pp. 1096
Author(s):  
M. S. Ray ◽  
B. S. Deepak
Keyword(s):  
Case Report ◽  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Standard Of Care ◽  
Clinical Situation ◽  
Stromal Tumor ◽  
Curative Therapy ◽  
Stromal Tumors ◽  
Mesenchymal Neoplasms

Gastrointestinal stromal tumors (GIST) are relatively rare pathology as compared with other mitotic lesions of GIT. However, GIST is the most common mesenchymal neoplasms of the gastrointestinal tract. Biopsy of the lesion and Immuno-Histo-Chemistry (IHC) for CD117 confirms the diagnosis. Surgery remains the standard of care and only potentially curative therapy for patients with primary, resectable, localized gastrointestinal stromal tumor. However, chemotherapy with Imatinib is added in neoadjuvant or adjuvant form according to clinical situation, and histopathological status of the lesion.

scholarly journals Extra-Gastrointestinal retroperitoneal giant stromal tumor complicated with intra-tumoral hemorrhage: case report and literature review

2015 ◽  
Vol 21 (1) ◽  
pp. 1-6
Author(s):  
B.A. Suciu ◽  
V. Bud ◽  
Doina Milutin ◽  
Ioana Halmaciu ◽  
C. Constantin ◽  
...  
Keyword(s):  
Case Report ◽  
Gastrointestinal Tract ◽  
Literature Review ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Stromal Tumor ◽  
Stromal Tumors ◽  
Pathological Characteristics ◽  
Mesenchymal Origin ◽  
Extragastrointestinal Stromal Tumor

Abstract Gastrointestinal stromal tumors are an uncommon sarcomas with mesenchymal origin that arises in the gastrointestinal tract. Recently, most of the published reports describe such tumors located outside of the gastrointestinal tract, with similar pathological characteristics and are named extra-gastrointestinal stromal tumors. We report the case of a patient suffering for a giant retroperitoneal extra-gastrointestinal stromal tumor, complicated with intra-tumoral hemorrhage. The particularity of this case is the presence of the intra-tumoral hemorrhage in a retroperitoneal extragastrointestinal stromal tumor that grew rapidly in volume (in 1 week).

Large Omental Metastases of a Gastrointestinal Stromal Tumor

Medicina ◽  
2011 ◽  
Vol 47 (11) ◽  
pp. 86
Author(s):  
Povilas Ignatavičius ◽  
Tomas Petraitis ◽  
Žilvinas Saladžinskas ◽  
Lilija Butkevičienė ◽  
Kristina Žvinienė
Keyword(s):  
Case Report ◽  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Metastatic Tumor ◽  
Stromal Tumor ◽  
Mesenchymal Tumors ◽  
Stromal Tumors ◽  
Cells Of Cajal

Gastrointestinal stromal tumors are rare tumors, originating from the interstitial cells of Cajal. They are the most common mesenchymal tumors of the gastrointestinal tract. Metastatic tumor is treated with imatinib mesylate. A case of large metastases of a gastrointestinal stromal tumor to the omentum, diagnosis and treatment principles are presented in this case report.

scholarly journals A Malignant Gastrointestinal Stromal Tumor of the Gallbladder Immunoreactive for PDGFRA and Negative for CD 117 Antigen (c-KIT)

HPB Surgery ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Athanasios Petrou ◽  
Pari Alexandrou ◽  
Alexandros Papalambros ◽  
Angelica Saetta ◽  
Paraskevi Fragkou ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Growth Factor Receptor ◽  
Stromal Tumor ◽  
Platelet Derived Growth Factor ◽  
Stromal Tumors ◽  
Cd 117 ◽  
Factor Receptor Alpha ◽  
Malignant Gists ◽  
First Time

Gastrointestinal stromal tumors (GISTs) compose the largest category of well-recognized nonepithelial neoplasms of the gastrointestinal tract (GI). GISTs of the gallbladder are extremely rare tumors. Only four malignant, two benign and one GIST-like tumor of the gall bladder have ever been described. The four malignant GISTs were all positive for CD 117 antigen (c-kit). We present for the first time a malignant gastrointestinal stromal tumor of the gallbladder, immunoreactive for platelet-derived growth factor receptor alpha (PDGFRA) and negative for CD 117 antigen (c-KIT).

scholarly journals Retroperitoneal Extragastrointestinal Stromal Tumor: Radiologic Pathologic Correlation

2014 ◽  
Vol 4 ◽  
pp. 34 ◽  
Author(s):  
Pankaj Watal ◽  
Swetang G. Brahmbhatt ◽  
Prashant J. Thoriya ◽  
Nandini U. Bahri
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumors ◽  
Cross Sectional ◽  
Stromal Tumors ◽  
Extragastrointestinal Stromal Tumor ◽  
Cross Sectional Imaging ◽  
Rare Site ◽  
Sectional Imaging ◽  
Histopathologic Findings ◽  
Histology And Immunohistochemistry

Neoplasms with histology and immunohistochemistry similar to gastrointestinal stromal tumors may occur primarily outside the gastrointestinal tract, usually in the omentum and mesentery. These are referred to as extragastrointestinal stromal tumors (EGISTs). Retroperitoneum is a very rare site for such neoplasms. We report a patient with EGIST in the retroperitoneum, elaborating the cross-sectional imaging and histopathologic findings.

scholarly journals Giant liver hemangioma in patient with ileal gastrointestinal stromal tumor

2014 ◽  
Vol 67 (1-2) ◽  
pp. 55-59
Author(s):  
Vasilije Antic ◽  
Marjan Micev ◽  
Danijela Baskic ◽  
Violeta Mladenovic
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Stromal Tumor ◽  
Surgical Removal ◽  
Liver Hemangioma ◽  
Palpable Mass ◽  
Gastrointestinal Malignancies ◽  
Stromal Tumors ◽  
The Right

Introduction. Gastrointestinal stromal tumors are the most common mesenchymal neoplasms of the gastrointestinal tract. These tumors represent more than 80% of all mesenchymal tumors found in the gastrointestinal tract, though they account for only approximately 3% of all gastrointestinal malignancies. Literature offers case reports, which describe symptomatic gastrointestinal stromal tumors and they generally represent patients with larger tumors. Case report. We present the case of a small gastrointestinal stromal tumor in a 40-year-old man, with associated giant liver hemangioma and fever, and with history of abdominal discomfort and fever. Clinical examination revealed hepatosplenomegaly, palpable mass in the right lower abdomen, and signs of neurofibromatosis type 1 (Morbus von Recklinghausen). Computed tomography revealed a giant tumor in the right lobe of the liver. Magnetic resonance showed abscess in the hemangioma of the liver. An intestinal tumor was incidentally found and excised during surgical laparotomy. An intestinal gastrointestinal stromal tumor was revealed by histopathology and confirmed by immunohistochemistry. Although a multidisciplinary team proposed surgical removal of the liver tumor mass, the surgeons decided to follow up the patient because of a high risk of new intervention. Conclusion. According to the available data, this is a very rare case of small intestinal gastrointestinal stromal tumor, with symptoms of fever and giant abscess in the liver hemangioma.

Liver metastasis from pancreatic gastrointestinal stromal tumor presenting 5 years after resection: a rare case with management challenges

2018 ◽  
pp. 1-3
Keyword(s):  
Gastrointestinal Tract ◽  
High Risk ◽  
Liver Metastasis ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Uncinate Process ◽  
Stromal Tumor ◽  
Distal Common Bile Duct ◽  
Stromal Tumors ◽  
Whipple’S Procedure

Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors arising from the gastrointestinal tract. Stromal tumors arising outside the gastrointestinal tract are called extra-gastrointestinal stromal tumors, usually found in omentum, mesentery, retroperitoneum and gallbladder. We report a case of 31 years old male with 3-month history of painless jaundice and undocumented weight loss. Computerized tomography scan showed a well-defined, rounded enhancing lesion in the uncinate process of pancreas measuring 53x49mm compressing the distal common bile duct. Percutaneous biopsy confirmed gastrointestinal stromal tumor. He underwent Whipple’s procedure followed by adjuvant imatinib due to high-risk features. He remained well for a long time and developed oligo-metastasis in liver 5 years after resection while he was still on imatinib. The patient underwent hepatic resection and remains well one year after the second resection on adjuvant treatment. Pancreatic extragastrointestinal stromal tumor involving uncinate process is a rare disease entity. First line of management is negative margin resection followed by adjuvant therapy with imatinib for high-risk tumors. In case of resectable liver metastasis, resection of metastasis followed by multimodal therapy seems to prolong the disease free and overall survival.

scholarly journals Extra - Intestinal Gastrointestinal Stromal Tumor of Omentum

2014 ◽  
Vol 4 (8) ◽  
pp. 682-684
Author(s):  
S Basnet ◽  
A Lakhey
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Rare Case ◽  
Stromal Tumor ◽  
Malignant Neoplasms ◽  
Mesenchymal Tumors ◽  
Stromal Tumors ◽  
Rare Tumors

Gastrointestinal stromal tumors are rare tumors, constituting less than 3% of all gastrointestinal malignant neoplasms but are the most common mesenchymal tumors of the gastrointestinal tract. Approximately 10% of gastrointestinal stromal tumors are extraintestinal and mostly arise from the mesentery or omentum. Here we report a rare case of an extraintestinal gastrointestinal stromal tumor of mesentery. Morphological and immunohistochemical features led to a diagnosis of extra-gastrointestinal stromal tumor.DOI: http://dx.doi.org/10.3126/jpn.v4i8.11610 Journal of Pathology of Nepal; Vol.4,No. 8 (2014) 682-684

Gastrointestinal Stromal Tumors: A Review of the Literature

2010 ◽  
Vol 134 (1) ◽  
pp. 134-141 ◽  
Author(s):  
Javier A. Laurini ◽  
J. Elliot Carter
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumors ◽  
Kinase Inhibitors ◽  
Spindle Cell ◽  
Stromal Tumors ◽  
Molecular Features ◽  
Mesenchymal Neoplasms ◽  
Neural Origin ◽  
Immunohistochemical Studies

Abstract Gastrointestinal stromal tumors are mesenchymal neoplasms with a spectrum of histologic appearances and biologic activity. The morphologic classification of these lesions has evolved over time, and molecular analysis has led to a better understanding of their nature. The histologic differential diagnosis for these lesions is broad and includes many spindle cell lesions of the gastrointestinal tract, including neoplasms of true smooth muscle and neural origin, proliferating fibrous lesions, metastatic neoplasms, and primary sarcomas of vascular and adipose origin. Immunohistochemical studies that include CD117 have become invaluable in the classification of mesenchymal lesions arising in the gastrointestinal tract. Treatment of gastrointestinal stromal tumors has historically been involved surgery, but the use of the chemotherapeutic agent imatinib mesylate for advanced disease has made accurate classification even more important. The molecular features have not only allowed us to understand the pathogenesis of these tumors but also have proven to be associated with response to kinase inhibitors.

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